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The findings reported here suggest that, in participants with the GRIK1 rs2832407*CC genotype, topiramate treatment enhances self-efficacy and reduces heavy drinking.
Findings indicate that SNPs in the GRIK1 gene is associated with altered cue-induced brain activation that is related to craving for alcohol and relapse risk.
Results suggested that the extracellular N-terminal region including the two CUB domains was largely responsible for the distinct regulatory effects of Neto1 (zeige NETO1 ELISA Kits) and Neto2 (zeige NETO2 ELISA Kits) on the desensitization properties of GluK1 homomeric receptors
In the present study, we have shown that gene-gene interaction of components of different systems associated with nicotine reinforcing effects, such as OPRM1 (zeige OPRM1 ELISA Kits) and GRIK1, rather than one gene polymorphism, is associated with smoking behavior.
This found that, among rs2832407*C of GRIK1 homozygotes, topiramate treatment produced the greatest reductions in the expected positive effects of drinking and desire to drink during the treatment period.
These results suggest that the effect of topiramate on drinking behavior, in which the GluK1-containing kainate receptor appears to play a key role, can be dissociated from its effect on weight.
Reduced Homer (zeige HOMER1 ELISA Kits) binding to mGluR5 (zeige GRM5 ELISA Kits) supports an inhibitory role for Homer (zeige HOMER1 ELISA Kits) interactions with mGluR5 (zeige GRM5 ELISA Kits) in mediating neuropathy.
Using the SNaPshot assay, we present evidence for allelic nondisjunction at rs363506 in the GRIK1 gene and rs2834235 and rs7283354 in the GARS-AIRS-GART (zeige GART ELISA Kits) gene in Down syndrome in India.
The association at rs455804 implicates GRIK1 as a novel susceptibility gene for HBV-related HCC (zeige FAM126A ELISA Kits), suggesting the involvement of glutamate (zeige GRIN1 ELISA Kits) signaling in the development of HBV-related HCC (zeige FAM126A ELISA Kits).
GRIK1 rs469472 to be possibly associated with schizophrenia in our independent case-control and family samples
GluK5 is almost exclusively localized to the presynaptic ribbon of photoreceptor terminals.
Animals trained in the trace fear conditioning protocol exhibited a transient increase in unedited GRIK1 RNA in the amygdala, and their learning efficiency correlated with unedited RNA levels in CA1 (zeige CA1 ELISA Kits).
results show that GluK1 and Go proteins are natural partners, accounting for the metabotropic effects of Kainate receptors.
integrity of Homer (zeige HOMER1 ELISA Kits) scaffolds is essential for normal glur5-evoked endocannabinoid functioning
We combine pharmacological, genetic, and electrophysiological approaches to show that cortical GluK1-containing kainate (KA) receptors are involved in scratching induced by histamine and non-histamine-dependent itching stimuli
The combined loss of the AMPA (zeige GRIA3 ELISA Kits) receptor auxiliary TARPg-2 subunit and the GluK5 subunit leads to early mouse lethality.
CaMKII-dependent phosphorylation of GluK5 is responsible for synaptic depression by untrapping of KARs from the PSD and increased diffusion away from synaptic sites.
these data further implicate Group 1 mGluR (zeige GRM8 ELISA Kits) signaling through Homer2 (zeige HOMER2 ELISA Kits) within the nucleus accumbens in excessive alcohol consumption
This study demonistrated that grik1 gene expression in mouse dorsal raphe nucleus
Activation of presynaptic GluK1 kainate receptors at lateral amygdala synapses results in the inhibition of glutamate (zeige GRIN1 ELISA Kits) release and the coupling of GluK1 receptors to a cascade involving the regulation of protein kinase A (PKA) activity.
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG\; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.
glutamate receptor, ionotropic, kainate 1
, glutamate receptor, ionotropic kainate 1
, excitatory amino acid receptor 3
, glutamate receptor 5
, glutamate receptor ionotropic, kainate 1
, glutamate receptor subunit 5