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Current studies suggest that increased Cyp7a1 expression and bile acid synthesis ameliorate hepatic inflammation through activation of FXR (zeige NR1H4 Proteine)
This study provides evidence that individuals carrying the G allele of CYP7A1 single nucleotide polymorphism are more responsive to high molecular weight beta-glucan's effect of lowering circulating cholesterol concentrations than individuals homozygous for the T allele.
Genetic variations in ABCG5 (zeige ABCG5 Proteine), CYP7A1, and DHCR7 (zeige DHCR7 Proteine) may contribute to differing responses of serum cholesterol to dairy intake among healthy adults.
The promoter polymorphism of the CYP7A1 gene has a pronounced impact on diurnal variation in CYP7A1 activity.
The finding that overexpression of HIF-1alpha (zeige HIF1A Proteine) increased the activity of the CYP7A1 promoter suggested that hypoxia decreased the expression of CYP7A1 in a HIF-1 (zeige HIF1A Proteine)-independent manner.
Macrophage cholesterol efflux in patients with type II diabetes mellitus was significantly reduced, and that this reduction was associated with the down-regulation of CYP7A1 expression.
CYP7A1 and APOE (zeige APOE Proteine) isoform are associated with the extent of reduction in circulating LDL cholesterol in response to plant sterols consumption.
The CYP7A1 rs7833904 polymorphism may modify the risk of CAD.
The CYP7A1 crystallographic models identify residues involved in cholest-4-en-3 (zeige EN1 Proteine)-one binding.
we identified for the first time a significant association of the A-204C polymorphism of the CYP7A1 gene and development of tuberculosis in a Moroccan population
although feeding LS-Xbp1 (zeige XBP1 Proteine)(-/-) mice cholesterol did not increase CYP7A1 expression, serum C4 levels increased significantly up to levels similar to chow-fed Xbp1 (zeige XBP1 Proteine)(fl/fl (zeige FLT3LG Proteine)) mice and the total bile acid pool normalized. In conclusion, loss of hepatic XBP1 (zeige XBP1 Proteine) decreased the bile acid pool and CYP7A1 synthetic activity.
Cyp7a1(-/-) mice have improved glucose sensitivity with reduced liver triglycerides and fecal bile acid excretion, but increased fecal fatty acid excretion and respiratory exchange ratio (RER) when fed a high-fat/high-cholesterol diet
HSF-1 (zeige HSF1 Proteine) ablation not only eliminates heat shock response, but it also transcriptionally up-regulates CYP7A1 and MDR1/P-gp (zeige ABCB4 Proteine) axis in WD-diet fed HSF-1 (zeige HSF1 Proteine)(-/-)/LDLr (zeige LDLR Proteine)(-/-) mice to reduce atherosclerosis.
Mice deficient in cholesterol 7 alpha-hydroxylase, supplemented with chenodeoxycholic acid, have altered liver and intestinal bile acids.
Activation of the VDR (zeige CYP27B1 Proteine) represses hepatic SHP (zeige LAMC1 Proteine) to increase levels of CYP7A1 and reduce cholesterol.
Cholesterol lowering properties of oats involve increased production of bile acids via the classic pathway with up-regulation of CYP7A1 and CYP8B1 (zeige CYP8B1 Proteine).
A CYP7A1/SREBP2 (zeige SREBF2 Proteine)/miR (zeige MLXIP Proteine)-33a axis plays a critical role in regulation of hepatic cholesterol, bile acid, and fatty acid synthesis.
Ileal Fibroblast Growth Factor-15 (FGF15) expression was significantly reduced in Asbt (zeige SLC10A2 Proteine)(-/-)apoE (zeige APOE Proteine)(-/-) mice and was inversely correlated with expression of hepatic cholesterol 7-hydroxylase (Cyp7a1).
HNF4alpha (zeige HNF4A Proteine) and LRH-1 (zeige NR5A2 Proteine) promote active transcription histone marks on the Cyp7a1 promoter that are reversed by FGF19 (zeige FGF19 Proteine) in a SHP (zeige LAMC1 Proteine)-dependent manner
the effect of polymorphism in the cholesterol 7-alpha hydroxylase gene locus and dietary cholesterol on cerebrum cholesterol in neonatal pigs fed sow's milk formulas are reported.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis.
, cholesterol 7-alpha-monooxygenase
, cytochrome P450 7A1
, cytochrome P450, subfamily VIIA polypeptide 1
, cholesterol 7 alpha hydroxylase
, cytochrome P450, 7a1
, cholesterol 7-alpha hydroxylase
, cytochrome P450 (cholesterol hydroxylase 7 alpha)
, cholesterol 7alpha-hydroxylase
, cholesterol 7 alpha-hydroxylase