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Increased expression of CYP1B1 is associated with ovarian/peritoneal endometriotic lesions.
CYP1B1 Leu432Val is associated with increased lung cancer susceptibility among Caucasians, and there is an interaction between CYP1B1 Leu432Val polymorphism and smoking, and Asn453- Ser (zeige SIGLEC1 ELISA Kits) and Ala119Ser may be not associated with lung cancer risk.
In this study, we identified 12 CYP1B1 mutations, 5 of which were novel. The frequency of CYP1B1 mutations in this cohort was comparable with other populations
CYP1B1 genotype activity and the microscopic and clinical phenotypes in human primary congenital glaucoma
Utilizing a mouse model, null for Cyp1b1 and expressing human CYP1B1, the study tested the hypothesis that hCYP1B1 is important for dibenzo[def,p]chrysene (DBC) transplacental carcinogenesis. hCYP1B1 genotype did not impact lung tumor multiplicity, but tended to enhance incidence compared to Cyp1b1 wild-type mice (P = 0.07).
CYP1B1 haplotypes could be more effective in predicting Head and Neck Squamous Cell Carcinoma risk.
Our data suggest that interaction of TEK (zeige TEK ELISA Kits) and CYP1B1 contributes to primary congenital glaucoma pathogenesis and argue that TEK (zeige TEK ELISA Kits)-CYP1B1 may perform overlapping as well as distinct functions in manifesting the disease etiology.
molecular basis of the variable phenotypes resulting from the defects in CYP1B1 by using subclones of 23 CYP1B1 mutants reported in glaucoma patients
Cyp1b1 regulation of ocular fissure closure indirectly affects neural crest migration and development through an RA-independent pathway.
MicroRNA-187-5p suppresses cancer cell progression in non-small cell lung cancer through down-regulation of CYP1B1.
CYP1B1 contributed to the development of Ang II (zeige AGT ELISA Kits)-induced abdominal aortic aneurysm and associated pathogenic events in mice, likely by enhancing oxidative stress and associated signaling events
Miroestrol suppressed beta-naphthoflavone increases in CYP1B1.
Findings provide evidence that CYP1B1 is directly involved in the development of cardiac hypertrophy.
Cyp1b1 affects external control of mouse hepatocytes, fatty acid homeostasis and signaling involving HNF4alpha (zeige HNF4A ELISA Kits) and PPARalpha (zeige PPARA ELISA Kits).
hypertension, and associated pathogenesis in ApoE (zeige APOE ELISA Kits)(-/-)/Cyp1b1(+/+) mice on an atherogenic diet are most likely dependent on CYP1B1-generated oxidative stress and increased plasma lipid levels independent of blood pressure and absorption of lipids.
Follicle stimulating hormone functions via p38 MAPK (zeige MAPK14 ELISA Kits)-induced dephosphorylation at Ser (zeige SIGLEC1 ELISA Kits)(727) of STAT1 (zeige STAT1 ELISA Kits) to downregulate Cyp1b1 expression and maintain the estradiol levels in mouse dominant follicles.
Cyp1b1 contributes to angiotensin II induced hypertension and its pathogenesis in male mice.
Suggest that Cyp1b1 plays a critical role in female mice in protecting against renal dysfunction and end-organ damage associated with ANG II (zeige AGT ELISA Kits)-induced hypertension.
Data indicaate that adduct formation in cytochrome P450 (zeige CYP ELISA Kits) Cyp1b1 knockout mice was significantly reduced compared to wild-type mice receiving dibenzo[def,p]chrysene (DBC).
CYP1B1 knockdown studies show CYP1B1 is not a significant factor in causing synergistic toxicity of PAHs, nor, in contrast to CYP1A, in providing protection
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma\; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.
cytochrome P450 1B1
, cytochrome P450, family 1, subfamily B, polypeptide 1
, aryl hydrocarbon hydroxylase
, cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile)
, flavoprotein-linked monooxygenase
, microsomal monooxygenase
, xenobiotic monooxygenase
, benz[a]anthracene inducible
, cytochrome P450, 1b1, benz[a]anthracene inducible
, cytochrome P450CMEF
, cytochrome P450EF
, cytochrome P450, subfamily 1B, polypeptide 1
, cytochrome P450RAP
, cytochrome P4501B