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This study shows that TFAP2C promoted lung tumor progression by upregulation of TGFBR1 (zeige TGFBR1 Proteine) and consequent activation of PAK1 (zeige PAK1 Proteine) signaling.
miR (zeige MLXIP Proteine)-137 is a Slug-induced miRNA that relays the pro-metastatic effects of Slug by targeting TFAP2C in non-small cell lung cancer cells.
TFAP2C might increase oncogenic miR (zeige MLXIP Proteine)-183 expression and consequently downregulate tumor-suppressive AKAP12 and decrease tumor-suppressive miR (zeige MLXIP Proteine)-33a expression and subsequently induce CDK6 (zeige CDK6 Proteine) in NSCLC cells.
Higher TFAP2C protein expression correlates with poor overall survival after 10 years of diagnosis in ERalpha (zeige ESR1 Proteine)-positive breast cancer.
TFAP2C has an important role in regulated luminal-specific genes and may be a viable therapeutic target in breast cancer.
ShRNA knockdown of AP-2gamma in neuroblastoma (zeige ARHGEF16 Proteine) cells results in significant inhibit of cell proliferation.
Knockdown of TFAP2C or RET (zeige RET Proteine) inhibited activation of ERK (zeige EPHB2 Proteine) and AKT (zeige AKT1 Proteine) in MCF-7 cells. Knockdown of TFAP2C, which controls ER (estrogen receptor (zeige ESR1 Proteine)) and RET (zeige RET Proteine), had a greater effect on cell growth than either RET (zeige RET Proteine) or ER alone.
role for TFAP2C in melanoma via its regulation of ECM1 (zeige ECM1 Proteine)
TFAP2C amplification and overexpression represents a genetic dependency in ERBB2 (zeige ERBB2 Proteine)+ve breast cancer.
TFAP2C regulates expression of the RET proto-oncogene (zeige RET Proteine) through five AP-2 (zeige GTF3A Proteine) regulatory sites in the RET (zeige RET Proteine) promoter.
Redundant activities of Tfap2a (zeige TFAP2A Proteine) and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos.
Expression of TFAP2beta (zeige TFAP2B Proteine) and TFAP2gamma genes in Xenopus laevis.
Tfap2c expression is altered in early preimplantation SCNT embryos, which may have developmental consequences resulting from genes influenced by Tfap2c, but expression was not different at the blastocyst stage and in placentomes.
TFAP2C in trophoblasts controls proliferation by repressing Cdkn1a (zeige CDKN1A Proteine) and activating the MAPK (zeige MAPK1 Proteine) pathway, further supporting differentiation of glycogen (zeige GYS1 Proteine) cells by activating the AKT (zeige AKT1 Proteine) pathway
these findings indicate that a reduction in the gene dosage of placental Tfap2c leads to morphological changes in the labyrinth at midgestation
TFAP2C regulates tumorigenesis, cell growth and survival in HER2 (zeige ERBB2 Proteine)-amplified breast cancer through transcriptional regulation of EGFR (zeige EGFR Proteine).
Transcription factor AP-2gamma induces early Cdx2 (zeige CDX2 Proteine) expression and represses HIPPO signaling to specify the trophectoderm lineage.
we characterize the cis (zeige CISH Proteine)-regulatory organization of a large genomic locus consisting of Tfap2c and Bmp7 (zeige BMP7 Proteine). We show that this locus is structurally partitioned into two distinct domains by the constitutive action of a discrete transition zone
mice with a heterozygous deletion of the TFAP2C target gene Nanos3 (zeige NANOS3 Proteine) are also prone to develop teratomas. These data highlight TFAP2C as a critical and dose-sensitive regulator of germ cell fate.
Tcfap2c is not required for Oct4 (zeige POU5F1 Proteine) silencing in mouse blastocysts, but may be necessary for the maintenance of Oct4 (zeige POU5F1 Proteine) expression during the 8 cell-to-morula transition.
critical roles for AP-2 (zeige TFAP2A Proteine) activity in retinogenesis, delineating the overlapping expression patterns of Tcfap2a (zeige TFAP2A Proteine), Tcfap2b (zeige TFAP2B Proteine), and Tcfap2c in the neural retina, and revealing a redundant requirement for Tcfap2a (zeige TFAP2A Proteine) and Tcfap2b (zeige TFAP2B Proteine) in horizontal and amacrine cell development
An important role for TCFAP2C, SMARCA4 (zeige SMARCA4 Proteine), and EOMES (zeige EOMES Proteine) in TS cell self-renewal.
Data suggest that Tcfap2c and Cdx2 (zeige CDX2 Proteine) cooperate to override the pluripotency program and establish the extraembryonic trophoblast maintenance program in murine embryos.
The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube.
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
, transcription factor AP-2 gamma
, transcription factor ap-2 gamma
, transcription factor AP-2 gamma-like
, activating enhancer binding protein 2 gamma
, activator protein 2 gamma
, activating enhancer-binding protein 2 gamma
, estrogen receptor factor 1
, transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma)
, transcription factor ERF-1
, stimulated by retinoic acid gene 2