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This study shows that TFAP2C promoted lung tumor progression by upregulation of TGFBR1 (zeige TGFBR1 ELISA Kits) and consequent activation of PAK1 (zeige PAK1 ELISA Kits) signaling.
miR (zeige MLXIP ELISA Kits)-137 is a Slug-induced miRNA that relays the pro-metastatic effects of Slug by targeting TFAP2C in non-small cell lung cancer cells.
TFAP2C might increase oncogenic miR (zeige MLXIP ELISA Kits)-183 expression and consequently downregulate tumor-suppressive AKAP12 (zeige AKAP12 ELISA Kits) and decrease tumor-suppressive miR (zeige MLXIP ELISA Kits)-33a expression and subsequently induce CDK6 (zeige CDK6 ELISA Kits) in NSCLC cells.
Higher TFAP2C protein expression correlates with poor overall survival after 10 years of diagnosis in ERalpha (zeige ESR1 ELISA Kits)-positive breast cancer.
TFAP2C has an important role in regulated luminal-specific genes and may be a viable therapeutic target in breast cancer.
ShRNA knockdown of AP-2gamma in neuroblastoma (zeige ARHGEF16 ELISA Kits) cells results in significant inhibit of cell proliferation.
Knockdown of TFAP2C or RET (zeige RET ELISA Kits) inhibited activation of ERK (zeige EPHB2 ELISA Kits) and AKT (zeige AKT1 ELISA Kits) in MCF-7 cells. Knockdown of TFAP2C, which controls ER (estrogen receptor (zeige ESR1 ELISA Kits)) and RET (zeige RET ELISA Kits), had a greater effect on cell growth than either RET (zeige RET ELISA Kits) or ER alone.
role for TFAP2C in melanoma via its regulation of ECM1 (zeige ECM1 ELISA Kits)
TFAP2C amplification and overexpression represents a genetic dependency in ERBB2 (zeige ERBB2 ELISA Kits)+ve breast cancer.
TFAP2C regulates expression of the RET proto-oncogene (zeige RET ELISA Kits) through five AP-2 (zeige GTF3A ELISA Kits) regulatory sites in the RET (zeige RET ELISA Kits) promoter.
Redundant activities of Tfap2a (zeige TFAP2A ELISA Kits) and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos.
Expression of TFAP2beta (zeige TFAP2B ELISA Kits) and TFAP2gamma genes in Xenopus laevis.
Tfap2c expression is altered in early preimplantation SCNT embryos, which may have developmental consequences resulting from genes influenced by Tfap2c, but expression was not different at the blastocyst stage and in placentomes.
TFAP2C in trophoblasts controls proliferation by repressing Cdkn1a (zeige CDKN1A ELISA Kits) and activating the MAPK (zeige MAPK1 ELISA Kits) pathway, further supporting differentiation of glycogen (zeige GYS1 ELISA Kits) cells by activating the AKT (zeige AKT1 ELISA Kits) pathway
these findings indicate that a reduction in the gene dosage of placental Tfap2c leads to morphological changes in the labyrinth at midgestation
TFAP2C regulates tumorigenesis, cell growth and survival in HER2 (zeige ERBB2 ELISA Kits)-amplified breast cancer through transcriptional regulation of EGFR (zeige EGFR ELISA Kits).
Transcription factor AP-2gamma induces early Cdx2 (zeige CDX2 ELISA Kits) expression and represses HIPPO signaling to specify the trophectoderm lineage.
we characterize the cis (zeige CISH ELISA Kits)-regulatory organization of a large genomic locus consisting of Tfap2c and Bmp7 (zeige BMP7 ELISA Kits). We show that this locus is structurally partitioned into two distinct domains by the constitutive action of a discrete transition zone
mice with a heterozygous deletion of the TFAP2C target gene Nanos3 are also prone to develop teratomas. These data highlight TFAP2C as a critical and dose-sensitive regulator of germ cell fate.
Tcfap2c is not required for Oct4 (zeige POU5F1 ELISA Kits) silencing in mouse blastocysts, but may be necessary for the maintenance of Oct4 (zeige POU5F1 ELISA Kits) expression during the 8 cell-to-morula transition.
critical roles for AP-2 (zeige TFAP2A ELISA Kits) activity in retinogenesis, delineating the overlapping expression patterns of Tcfap2a (zeige TFAP2A ELISA Kits), Tcfap2b (zeige TFAP2B ELISA Kits), and Tcfap2c in the neural retina, and revealing a redundant requirement for Tcfap2a (zeige TFAP2A ELISA Kits) and Tcfap2b (zeige TFAP2B ELISA Kits) in horizontal and amacrine cell development
An important role for TCFAP2C, SMARCA4 (zeige SMARCA4 ELISA Kits), and EOMES (zeige EOMES ELISA Kits) in TS cell self-renewal.
Data suggest that Tcfap2c and Cdx2 (zeige CDX2 ELISA Kits) cooperate to override the pluripotency program and establish the extraembryonic trophoblast maintenance program in murine embryos.
The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube.
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
, transcription factor AP-2 gamma
, transcription factor ap-2 gamma
, transcription factor AP-2 gamma-like
, activating enhancer binding protein 2 gamma
, activator protein 2 gamma
, activating enhancer-binding protein 2 gamma
, estrogen receptor factor 1
, transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma)
, transcription factor ERF-1
, stimulated by retinoic acid gene 2