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Human Monoclonal SPI1 Primary Antibody für IP, WB - ABIN967452
Klemsz, McKercher, Celada, Van Beveren, Maki: The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. in Cell 1990
Show all 7 Pubmed References
Human Polyclonal SPI1 Primary Antibody für ELISA, WB - ABIN314238
Harendza, Lovett, Stahl: The hematopoietic transcription factor PU.1 represses gelatinase A transcription in glomerular mesangial cells. in The Journal of biological chemistry 2000
Show all 2 Pubmed References
Human Monoclonal SPI1 Primary Antibody für FACS, ELISA - ABIN3072909
Xu, Wang, Wang, Wu, Zhao, Zhu, Qiu, Xue, Shao, Guo, Li: PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60. in Leukemia research 2010
Human Polyclonal SPI1 Primary Antibody für WB - ABIN4240538
McDevit, Nikolajczyk: Changes in immunoglobulin-nucleoprotein complex structure mapped by chromatin immunoprecipitation. in Molecular immunology 2006
The analysis points to a critical role for Hoxa9 (zeige HOXA9 Antikörper) and PU.1 in distal regulation of c-myb (zeige MYB Antikörper) expression in murine myeloid cells during iL-6 (zeige IL6 Antikörper)-induced cell differentiation.
These studies reveal an important role for PU.1 in the regulation of Igkappa transcription and rearrangement and a requirement for PU.1 and Spi-B (zeige SPIB Antikörper) in B cell development.
expression of an essential mediator of neutrophil terminal differentiation, the ets transcription factor PU.1, was significantly decreased in Hbb(th3/+) neutrophils in a model of beta-thalassemia
Moreover, the expression of a cell proliferation marker Ki67 (zeige MKI67 Antikörper) was significantly decreased in tumors from the mice not taking doxycycline, compared with that of tumors from the mice continuously taking doxycycline. The present data strongly suggest that PU.1 functions as a tumor suppressor of myeloma cells in vivo.
the affinities of two sequence-divergent ETS (zeige ETS1 Antikörper) homologs, PU.1 and Ets-1 (zeige ETS1 Antikörper), to DNA sites harboring a hemi- and fully methylated CpG dinucleotide, were measured.
this study shows that PU.1 functions as a positive regulator of CD11c (zeige ITGAX Antikörper) gene expression by directly binding to the Itgax (zeige ITGAX Antikörper) promoter and through transactivation of the Irf4 (zeige IRF4 Antikörper) gene
Here we demonstrate that the transcription factors SPI1 (PU.1) and HOXC13 synergistically regulate Zfp521 (zeige ZNF521 Antikörper) expression, and identify the regions of the Zfp521 (zeige ZNF521 Antikörper) promoter required for this transcriptional activity. We also show that SPI1 and HOXC13 activate Zfp521 (zeige ZNF521 Antikörper) in a dose-dependent manner.
findings suggest that Gata1 (zeige GATA1 Antikörper) & PU.1 transcription factors are only executing and reinforcing lineage choice once made. These results challenge the current prevailing model of early myeloid lineage choice
involved in osteoclast development by transactivating NFATc1 (zeige NFATC1 Antikörper) expression via direct binding to the NFATc1 (zeige NFATC1 Antikörper) promoter
GATA1 (zeige GATA1 Antikörper) and PU.1 bind in vitro and in vivo the proximal promoter region of the RPS19 (zeige RPS19 Antikörper) gene which is frequently mutated in Diamond-Blackfan Anemia.
PU.1 and IL-9 (zeige IL9 Antikörper) may play a role in AD pathogenesis and relate to disease severity and clinical eruption types.
PU.1-induced apoptosis in myeloma cells is associated with IRF4 (zeige IRF4 Antikörper) downregulation and subsequent IRF7 (zeige IRF7 Antikörper) upregulation.
Most cases of histiocytic sarcoma expressed histiocytic markers CD68 (zeige CD68 Antikörper) (6 of 7 cases), CD163 (zeige CD163 Antikörper) (5 of 5 cases), and PU.1 (3 of 4 cases).
findings highlight a unique role of SPI1 fusions in high-risk pediatric T cell acute lymphoblastic leukemia
expression of an essential mediator of neutrophil terminal differentiation, the ets transcription factor PU.1, was significantly decreased in Hbb(th3/+) neutrophils in beta-thalassemia
RUNX1 (zeige RUNX1 Antikörper) overexpression induced partial DNA demethylation at SPI1 proximal promoter.
This study demonstrated the novel role of PU.1 in the immune response to A. fumigatus through upregulation of Dectin-1 (zeige CLEC7A Antikörper) expression and its translocation to the nucleus in A. fumigatus-stimulated THP-1 (zeige GLI2 Antikörper) cells.
PU.1 is an important modulator of VDR signaling in monocytes.
Forced FOG1 (zeige ZFPM1 Antikörper) protein expression in K562 erythroleukemia cells induced the expression of SLC4A1 (zeige SLC4A1 Antikörper) protein, but repressed that of transcription factor PU.1.
The vertical and paralleled Pu.1/Spi-b (zeige SPIB Antikörper) regulatory networks control the development of rostral blood island and ventral wall of dorsal aorta-borne macrophages by regulating Irf8 (zeige IRF8 Antikörper).
eaf1 (zeige EAF1 Antikörper) has a role in suppressing foxo3b expression to modulate transcriptional activity of gata1 (zeige GATA1 Antikörper) and spi1 in primitive hematopoiesis
Our results indicate that Kzp (zeige ANPEP Antikörper) is a critical transcriptional factor for the expression of gata2 and pu.1 to modulate primitive hematopoiesis.
Runx1 (zeige RUNX1 Antikörper) is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.
The authors show that tif1gamma (zeige TRIM33 Antikörper) modulates the erythroid versus myeloid fate outcomes from HSCs by differentially controlling the levels of gata1 (zeige GATA1 Antikörper) and pu.1.
found a gene group downregulated on spi1 knockdown,containing all 5 previously identified Spi1-dependent genes as well as a large set of novel immune-related genes
In zebrafish, spi1 marks a rostral population of LPM cells committed to a myeloid fate anatomically separated from and developmentally independent of erythroid commitment in the caudal (zeige CAD Antikörper) LPM.
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.
, contrapsin-like protease inhibitor 3
, contrapsin-like protease inhibitor-related protein
, liver regeneration protein lrryan
, serine protease inhibitor 1
, serine protease inhibitor 2.1
, serine protease inhibitor 2a
, serine protease inhibitor A3L
, serpin A3L
, 31 kDa transforming protein
, 31 kDa-transforming protein
, SPI-1 proto-oncogene
, hematopoietic transcription factor PU.1
, spleen focus forming virus (SFFV) proviral integration oncogene spi1
, transcription factor PU.1
, SFFV proviral integration 1 protein
, SFFV proviral integration 1
, spleen focus forming virus proviral integration oncogene spi1
, Spi-1/PU.1 transcription factor
, transcription factor spi1