anti-Meerschweinchen SMC1A Antikörper für Western Blotting

Recommended SMC1A Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Structural Maintenance of Chromosomes 1A (SMC1A) Antikörper
  • smc1a
  • smc1l1
  • zgc:76902
  • im:7158706
  • SMC1L1
  • SMC1L2
  • NV15570
  • CDLS2
  • DXS423E
  • SB1.8
  • SMC1
  • SMC1alpha
  • SMCB
  • 5830426I24Rik
  • SMC-1A
  • Sb1.8
  • Smc1
  • Smc1alpha
  • Smc1l1
  • Smcb
  • mKIAA0178
  • smc1aa
  • smc1
  • xSMC1
  • structural maintenance of chromosomes 1A, like
  • structural maintenance of chromosomes 1A
  • structural maintenance of chromosomes 1B
  • structural maintenance of chromosomes 1A L homeolog
  • structural maintenance of chromosomes 1A b
  • smc1al
  • SMC1A
  • SMC1B
  • Smc1a
  • smc1a
  • smc1a.L
  • smc1ab
Epitop
C-Term
47
31
28
16
13
10
8
4
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus), Zebrafisch
230
131
51
9
8
7
6
6
5
5
3
3
3
2
2
Wirt
Kaninchen
183
43
3
2
1
Klonalität
Polyklonal
Konjugat
Dieser SMC1A Antikörper ist unkonjugiert
5
5
5
4
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
189
88
57
56
53
36
30
27
24
7
3
1
1
1
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN2780766
$ 289.00
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN324497 WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal
1 ABIN1959651 IP PLA WB Rabbit IgG pSer957 Anmelden zum Anzeigen Polyclonal
1 ABIN2628552 ICC IF IHC (p) IP PLA WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal
1 ABIN1936553 IP PLA WB Goat IgG AA 1183-1233 Anmelden zum Anzeigen Polyclonal
1 ABIN1959455 IP WB Rabbit pSer957 Anmelden zum Anzeigen Polyclonal

General

Antigen Structural Maintenance of Chromosomes 1A (SMC1A) Antikörper
Epitop C-Term
(47), (31), (28), (16), (13), (10), (8), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus), Zebrafisch
(230), (131), (51), (9), (8), (7), (6), (6), (5), (5), (3), (3), (3), (2), (2)
Wirt Kaninchen
(183), (43), (3), (2), (1)
Klonalität
Polyklonal
Konjugat Dieser SMC1A Antikörper ist unkonjugiert
(5), (5), (5), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Applikation Immunohistochemistry (IHC), Western Blotting (WB)
(189), (88), (57), (56), (53), (36), (30), (27), (24), (7), (3), (1), (1), (1), (1)
Pubmed 1 Publikation vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-SMC1A Antikörper

Target Details SMC1A Anwendungsinformationen Handhabung Referenzen für anti-SMC1A Antikörper (ABIN2780766) Bilder
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN984120.
Sequenz VISLKEEFYT KAESLIGVYP EQGDCVISKV LTFDLTKYPD ANPNPNEQ
Homologie Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%
Produktmerkmale This is a rabbit polyclonal antibody against SMC1A. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human SMC1A

Target Details SMC1A

Produktdetails anti-SMC1A Antikörper Anwendungsinformationen Handhabung Referenzen für anti-SMC1A Antikörper (ABIN2780766) Bilder zurück nach oben
Antigen
Andere Bezeichnung SMC1A (SMC1A Antibody Abstract)
Hintergrund The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by SMC1A gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the SMC1A protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CDLS2, DKFZp686L19178, DXS423E, KIAA0178, MGC138332, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
Protein Interaction Partner: UBC, SUMO2, STAU1, RPA3, RPA2, RPA1, RNF2, EED, KIF13A, ARMCX3, CDK20, ANKRD28, HDAC11, HDAC8, SMC1A, RFC1, POLA1, MCM7, MCM6, METTL21B, WHSC1, NOTCH1, SF3B3, ACIN1, SMC2, RBM14, SMC3, RAD21, NSMCE2, FBXO6, CUL3, NEDD8, CDK2, CEBPA, CDK8, NIPBL, MDC1, POL
Protein Size: 1233
Molekulargewicht 143 kDa
Gen-ID 8243
NCBI Accession NM_006306, NP_006297
UniProt Q14683
Pathways Stem Cell Maintenance

Anwendungsinformationen

Produktdetails anti-SMC1A Antikörper Target Details SMC1A Handhabung Referenzen für anti-SMC1A Antikörper (ABIN2780766) Bilder zurück nach oben
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 1233 AA

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-SMC1A Antikörper Target Details SMC1A Anwendungsinformationen Referenzen für anti-SMC1A Antikörper (ABIN2780766) Bilder zurück nach oben
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SMC1A Antikörper (ABIN2780766)

Produktdetails anti-SMC1A Antikörper Target Details SMC1A Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Barber, McManus, Yuen, Reis, Parmigiani, Shen, Barrett, Nouhi, Spencer, Markowitz, Velculescu, Kinzler, Vogelstein, Lengauer, Hieter: "Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 9, pp. 3443-8, 2008

Bilder

Produktdetails anti-SMC1A Antikörper Target Details SMC1A Anwendungsinformationen Handhabung Referenzen für anti-SMC1A Antikörper (ABIN2780766) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Structural Maintenance of Chromosomes 1A (SMC1A) (C-Term) antibody (ABIN2780766) WB Suggested Anti-SMC1A Antibody Titration: 0.2-1 ug/ml
ELISA Titer: