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In the absence of PCM1, Mib1 destabilizes Talpid3 through poly-ubiquitylation and suppresses cilium assembly.
Data suggest that USP9X as an integral component of centrosome where it functions to stabilize PCM1 and CEP55 and to promote centrosome biogenesis; N-terminal domain of USP9X appears to be responsible for physical association of USP9X with PCM1 and CEP55. (USP9X = ubiquitin-specific protease 9X; PCM1 = pericentriolar material 1 protein; CEP55 = 55kDa centrosomal protein)
a novel variant in the PCM1 (zeige MBD1 ELISA Kits) 3'UTR (zeige UTS2R ELISA Kits) is significantly associated with ovarian cancer
no association between the PCM1 (zeige MBD1 ELISA Kits) gene and schizophrenia in a Japanese population
Haematological neoplasms associated with t(8;9)(p22 (zeige DYNC1H1 ELISA Kits);p24); PCM1 (zeige MBD1 ELISA Kits)-JAK2 (zeige JAK2 ELISA Kits) have features in common and we suggest that they should be recognized as a specific entity in the WHO classification
these data suggest a mechanism whereby the recruitment of Plk1 (zeige PLK1 ELISA Kits) to pericentriolar matrix by PCM1 (zeige MBD1 ELISA Kits) plays a pivotal role in the regulation of primary cilia disassembly before mitotic entry.
Chromosomal translocation [t(8;9)(p22 (zeige DYNC1H1 ELISA Kits);p24)]/PCM1 (zeige MBD1 ELISA Kits)-JAK2 (zeige JAK2 ELISA Kits) fusion protein activates SOCS2 (zeige SOCS2 ELISA Kits) and SOCS3 (zeige SOCS3 ELISA Kits) via STAT5 (zeige STAT5A ELISA Kits) in a cutaneous T-cell lymphoma cell line.
CEP90 physically interacts with PCM-1 at centriolar satellites, and this interaction is essential for centrosomal accumulation of the centriolar satellites and eventually for primary cilia formation.
PCM1 (zeige MBD1 ELISA Kits) interacts with Hook2 (zeige HOOK2 ELISA Kits) in a complex that regulates a limiting step required for further initiation of ciliogenesis after centriole maturation.
NEK7 (zeige NEK7 ELISA Kits) is essential for PCM (zeige PCMT1 ELISA Kits) accumulation in a cell cycle stage-specific manner.
MicroRNA (miR (zeige MLXIP ELISA Kits))-128 regulates the proliferation and differentiation of neural progenitor cells by repressing pericentriolar material 1 (PCM1).
haploinsufficiency at the Pcm1 (zeige MBD1 ELISA Kits) locus can induce a range of neuroanatomical and behavioral phenotypes that support the candidacy of this locus in neuropsychiatric disorders.
deletion of Htt (zeige HTT ELISA Kits) in ependymal cells led to PCM1 (zeige MBD1 ELISA Kits) mislocalization, alteration of the cilia layer, and hydrocephalus
results identify a novel role for PCM- 1 (zeige MBD1 ELISA Kits) in cell cycle regulation, and indicate that PCM-1 (zeige MBD1 ELISA Kits) must fulfill an essential function for cells to complete interphase
Pcm1 (zeige MBD1 ELISA Kits) colocalized with centrosomal components in cytoplasmic granules surrounding nascent centrioles. Interfering with Pcm1 (zeige MBD1 ELISA Kits) reduced the amount of centrosomal proteins at basal bodies but did not prevent centriole assembly.
The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma.
pericentriolar material 1
, pericentriolar material 1 protein-like
, Pericentriolar material 1 protein-like
, pericentriolar material 1 protein
, pericentriolar material 1, PCM1
, pericentriolar material gene 1
, pericentriolar material-1