SORL1 Proteine (SORL1)

Bezeichnung:
Sortilin-Related Receptor, L(DLR Class) A Repeats Containing Proteine (SORL1)
Auf www.antikoerper-online.de finden Sie aktuell 2 Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1) Proteine von 2 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SORL1 Antikörper (98) und SORL1 Kits (9) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 113 SORL1 Produkte verfügbar.
Synonyme:
2900010L19Rik, AI596264, AW261561, C11orf32, gp250, Lr11, LRP9, mSorLA, RGD619914, SORL1, SorLA, SorLA-1
alle Proteine anzeigen Gen GeneID UniProt
SORL1 6653 Q92673
Maus SORL1 SORL1 20660 O88307
Ratte SORL1 SORL1 300652  

Weitere Synonyme anzeigen

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Weitere Proteine zu SORL1 Interaktionspartnern

Human Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1) Interaktionspartner

  1. SorLA ectodomain, released from the cell membrane upon enzymatic cleavage of full-length SorLA, may act as an IL-6 (zeige IL6 Proteine) carrier protein that stabilizes IL-6 (zeige IL6 Proteine) and its capacity for trans signaling.

  2. observed a 1.5-fold enrichment of rare non-synonymous variants of sortilin-related receptor 1 in Alzheimer's disease patients

  3. This review article discusses the molecular mechanisms that govern sorting of SORLA and its cargo in multiple cell types, and why genetic defects in this receptor results in devastating diseases. [review]

  4. The presence of rare coding variants in SORL1 in three different European American cohorts: early-onset, late-onset AD (LOAD) and familial LOAD, was examined.

  5. sLR11 levels in bile may be indicative of cancer cell conditions and may serve as potential novel biomarker in patients with BTC (zeige BTC Proteine) and PC

  6. SORL1 protein is involved with late onset Alzheimer's disease. [review]

  7. The DNA methylation (zeige HELLS Proteine) of the SORL1 5'-flanking region may significantly influence the manifestation of mild cognitive impairment in T2 Diabetes mellitus, and might be associated with its neurocognitive presentation.

  8. Findings provide evidence that sortilin (zeige SORT1 Proteine) receptor 1 rs3824968 modulates regional gray matter volume and is associated with brain trajectory during the adult lifespan.

  9. Serum LR11 reflects the development of vascular lesions in patients with serious coronary artery lesions.

  10. Elevated sLR11 levels may increase the cardiovascular disease risk especially in subjects with delayed clearance of triglyceride-rich remnants, such as in familial hypercholesterolemia patients.

Mouse (Murine) Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1) Interaktionspartner

  1. SorLA ectodomain, released from the cell membrane upon enzymatic cleavage of full-length SorLA, may act as an IL-6 (zeige IL6 Proteine) carrier protein that stabilizes IL-6 (zeige IL6 Proteine) and its capacity for trans signaling.

  2. We identify binding and trafficking interactions between two of these factors, SORLA and SNX27 (zeige SNX27 Proteine), and demonstrate that SNX27 (zeige SNX27 Proteine) can direct trafficking of SORLA and the Abeta (zeige APP Proteine) precursor APP (zeige APP Proteine) to the cell surface to limit the production of Abeta (zeige APP Proteine). Diversion APP (zeige APP Proteine) to the cell surface through modulation of this molecular complex may represent a complimentary strategy for future development in AD treatment.

  3. LR11 regulated vascular smooth muscle cell proliferation during the progression of hypoxia-induced medial thickening in mice.

  4. Therefore, SORL1 activation by 6-shogaol provides neuronal cell survival through the inhibition of Abeta (zeige APP Proteine) production. These results indicate that 6-shogaol should be regarded as an SORL1 activator and a potential preventive agent for the treatment of AD.

  5. Data strongly suggest an involvement of LR11 in mediating the harmful effects of a high-fat diet on CVD progression.

  6. Mice lacking LR11 are protected from diet-induced obesity associated with an increased browning of white adipose tissue and hypermetabolism.

  7. using massively parallel reporter assays, we dissect the enhancer activity of three liver eExons (SORL1 exon 17, TRAF3IP2 (zeige TRAF3IP2 Proteine) exon 2, PPARG (zeige PPARG Proteine) exon 6) at single nucleotide resolution in the mouse liver

  8. Data indicate that activation of alpha(2A) adrenergic receptor (alpha(2A)AR (zeige ADRA2A Proteine)) signaling disrupts transgenic amyloid precursor protein (APP (zeige APP Proteine)) interaction with sorting-related receptor with A repeat (SorLA) in cells and brain.

  9. SORLA-mediated trafficking of TrkB (zeige NTRK2 Proteine) enhances the response of neurons to BDNF (zeige BDNF Proteine).

  10. SorLA acts as sorting receptor for the GDNF (zeige GDNF Proteine)/GFRalpha1 (zeige GFRA1 Proteine) complex, directing it from the cell surface to endosomes.

SORL1 Protein Überblick

Protein Überblick

This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.

Alternative names and synonyms associated with SORL1

  • sortilin-related receptor, L(DLR class) A repeats containing (sorl1)
  • sortilin-related receptor, L(DLR class) A repeats-containing (SORL1)
  • sortilin-related receptor, L(DLR class) A repeats-containing (LOC100226349)
  • sortilin-related receptor, L(DLR class) A repeats-containing (sorl1)
  • sortilin-related receptor, L(DLR class) A repeats containing (SORL1)
  • sortilin-related receptor, LDLR class A repeats-containing (Sorl1)
  • 2900010L19Rik Protein
  • AI596264 Protein
  • AW261561 Protein
  • C11orf32 Protein
  • gp250 Protein
  • Lr11 Protein
  • LRP9 Protein
  • mSorLA Protein
  • RGD619914 Protein
  • SORL1 Protein
  • SorLA Protein
  • SorLA-1 Protein

Bezeichner auf Proteinebene für SORL1

sortilin-related receptor, L(DLR class) A repeats containing , sortilin-related receptor, L(DLR class) A repeats-containing , sortilin-related receptor-like , LDLR relative with 11 ligand-binding repeats , low-density lipoprotein receptor relative with 11 ligand-binding repeats , mosaic protein LR11 , sortilin-related receptor , sorting protein-related receptor containing LDLR class A repeats , LR11 , sorLA , sorLA-1

GENE ID SPEZIES
100566946 Anolis carolinensis
582560 Strongylocentrotus purpuratus
713011 Macaca mulatta
100024063 Monodelphis domestica
100071572 Equus caballus
100073504 Ornithorhynchus anatinus
100226349 Taeniopygia guttata
100490681 Xenopus (Silurana) tropicalis
100524036 Sus scrofa
6653 Homo sapiens
479408 Canis lupus familiaris
533166 Bos taurus
395998 Gallus gallus
100009378 Oryctolagus cuniculus
20660 Mus musculus
300652 Rattus norvegicus
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