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The results of this study support the effect of SORL1 gene on the disease risks and pathognomonic surrogates of Alzheimer's disease and mild cognitive impairment.
Study provides the first evidence that the sortilin-related receptor 1 gene is associated with brain functional connectivity density differences in healthy young adults.
Analysis of the molecular mechanism for the association of SORL1 with obesity: there is a genetic link between neurodegeneration and metabolism that converges on the receptor SORLA
This review will provide a comprehensive overview of the evidence implicating SORLA-mediated protein sorting in neurodegenerative processes, and how receptor gene variants in the human population impair functional receptor expression in sporadic but possibly also in autosomal-dominant forms of Alzheimer's disease.
SorLA ectodomain, released from the cell membrane upon enzymatic cleavage of full-length SorLA, may act as an IL-6 (zeige IL6 ELISA Kits) carrier protein that stabilizes IL-6 (zeige IL6 ELISA Kits) and its capacity for trans signaling.
observed a 1.5-fold enrichment of rare non-synonymous variants of sortilin-related receptor 1 in Alzheimer's disease patients
This review article discusses the molecular mechanisms that govern sorting of SORLA and its cargo in multiple cell types, and why genetic defects in this receptor results in devastating diseases. [review]
The presence of rare coding variants in SORL1 in three different European American cohorts: early-onset, late-onset AD (LOAD) and familial LOAD, was examined.
sLR11 levels in bile may be indicative of cancer cell conditions and may serve as potential novel biomarker in patients with BTC (zeige BTC ELISA Kits) and PC
SORL1 protein is involved with late onset Alzheimer's disease. [review]
Results demonstrate that the lack of SORLA results in accumulation of phosphorylated synapsins in cortex and hippocampus. Authors propose an underlying molecular mechanism by demonstrating that SORLA interacts with phosphorylated synapsins through 14-3-3 adaptor proteins to deliver synapsins to calpain-mediated proteolytic degradation.
We identify binding and trafficking interactions between two of these factors, SORLA and SNX27 (zeige SNX27 ELISA Kits), and demonstrate that SNX27 (zeige SNX27 ELISA Kits) can direct trafficking of SORLA and the Abeta (zeige APP ELISA Kits) precursor APP (zeige APP ELISA Kits) to the cell surface to limit the production of Abeta (zeige APP ELISA Kits). Diversion APP (zeige APP ELISA Kits) to the cell surface through modulation of this molecular complex may represent a complimentary strategy for future development in AD treatment.
LR11 regulated vascular smooth muscle cell proliferation during the progression of hypoxia-induced medial thickening in mice.
Therefore, SORL1 activation by 6-shogaol provides neuronal cell survival through the inhibition of Abeta (zeige APP ELISA Kits) production. These results indicate that 6-shogaol should be regarded as an SORL1 activator and a potential preventive agent for the treatment of AD.
Data strongly suggest an involvement of LR11 in mediating the harmful effects of a high-fat diet on CVD progression.
Mice lacking LR11 are protected from diet-induced obesity associated with an increased browning of white adipose tissue and hypermetabolism.
using massively parallel reporter assays, we dissect the enhancer activity of three liver eExons (SORL1 exon 17, TRAF3IP2 (zeige TRAF3IP2 ELISA Kits) exon 2, PPARG (zeige PPARG ELISA Kits) exon 6) at single nucleotide resolution in the mouse liver
Data indicate that activation of alpha(2A) adrenergic receptor (alpha(2A)AR (zeige ADRA2A ELISA Kits)) signaling disrupts transgenic amyloid precursor protein (APP (zeige APP ELISA Kits)) interaction with sorting-related receptor with A repeat (SorLA) in cells and brain.
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.
sortilin-related receptor, L(DLR class) A repeats containing
, sortilin-related receptor, L(DLR class) A repeats-containing
, sortilin-related receptor-like
, LDLR relative with 11 ligand-binding repeats
, low-density lipoprotein receptor relative with 11 ligand-binding repeats
, mosaic protein LR11
, sortilin-related receptor
, sorting protein-related receptor containing LDLR class A repeats