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Mouse (Murine) Monoclonal UNC13B Primary Antibody für IF, WB - ABIN968305
Betz, Ashery, Rickmann, Augustin, Neher, Südhof, Rettig, Brose: Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release. in Neuron 1998
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Mouse (Murine) Monoclonal UNC13B Primary Antibody für IF, WB - ABIN968306
Brose, Hofmann, Hata, Südhof: Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins. in The Journal of biological chemistry 1995
Show all 5 Pubmed References
Human Polyclonal UNC13B Primary Antibody für FACS, WB - ABIN652852
Sjöblom, Jones, Wood, Parsons, Lin, Barber, Mandelker, Leary, Ptak, Silliman, Szabo, Buckhaults, Farrell, Meeh, Markowitz, Willis, Dawson, Willson, Gazdar, Hartigan, Wu, Liu, Parmigiani, Park et al.: The consensus coding sequences of human breast and colorectal cancers. ... in Science (New York, N.Y.) 2006
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A rare missense variation (V1525M) in UNC13B was identified by WES in the multiplex family; this variation was present in five of six affected individuals, but not in eight unaffected individuals or one individual of unknown disease status. Resequencing UNC13B coding regions identified five rare missense variations (T103M, M813T, P1349T, I1362T, and V1525M).
The 1-5-8-26 CaM binding motif discovered in Munc13-1 cannot be induced in the classical CaM target skMLCK, indicating unique features of the Munc13 CaM binding motif.
Munc13-1 (zeige UNC13A Antikörper) regulates insulin (zeige INS Antikörper) exocytosis
MUNC13-4 (zeige UNC13D Antikörper) mutations play a role in the development of familial haemophagocytic lymphohistiocytosis subtype 3 through a defective cytotoxic pathway
Data suggest that diacylglycerol-activated hmunc13 serves as an effector of Rab34 (zeige RAB34 Antikörper), mediating lysosome-Golgi trafficking.
Data identified a polymorphism in the UNC13B gene associated with nephropathy. UNC13B mediates apopotosis in glomerular cells in the presence of hyperglycemia, an event occurring early in the development of nephropathy.
In the bound state, the hydrophobic anchor residue of the calmodulin (CaM)-binding motif in Munc13 contacts two distinct methionine residues in the carboxyl-terminal domain of CaM.
mechanistic basis for high glucose-induced protein secretion is through interaction of munc13 and rab34 (zeige RAB34 Antikörper), indicating a potentially critical role for this newly described pathway in the pathogenesis of DN.
SIGNIFICANCE STATEMENT: DBA (zeige RPS19 Antikörper)/2J and C57BL/6J mice have been used to understand the genetic mechanisms controlling behaviors related to a number of psychiatric illnesses. However, the fundamental neurobiological mechanisms producing these behavioral characteristics remain unresolved. Here we identify a critical family of presynaptic proteins differentially expressed by these strains that control strain-dependent synaptic ph
Munc13-2 is recruited to synapses by the AZ protein ELKS1.
Munc13-2 plays a fundamental role in large dense-core vesicle exocytosis, but in contrast to synapses lacking Munc13s, the corresponding chromaffin cells do not exhibit a vesicle docking defect.
Data demonstrate that Munc13-1 (zeige UNC13A Antikörper) and DOC2B (zeige DOC2B Antikörper) have different effects on network activity and that by enhancing asynchronous release, DOC2B (zeige DOC2B Antikörper) exerts its properties to increase spiking activity and elevate synchronization between neurons within network bursts
Munc13-1 (zeige UNC13A Antikörper) isoform is functionaly redundant in cytotoxic T lymphocytes.
betaARs couple to a cAMP/Epac (zeige RAPGEF3 Antikörper)/PLC (zeige HSPG2 Antikörper)/Munc13-1 (zeige UNC13A Antikörper)/Rab3a (zeige RAB3A Antikörper)/RIM1a (zeige RIMS1 Antikörper)-dependent pathway to enhance glutamate (zeige GRIN1 Antikörper) release at cerebrocortical nerve terminals.
Our data establish Munc13-1 (zeige UNC13A Antikörper) as a major presynaptic target of Ca(2 (zeige CA2 Antikörper)+)-Calmodulin signaling and show that the Ca(2 (zeige CA2 Antikörper)+)-Calmodulin-Munc13-1 (zeige UNC13A Antikörper) complex is a pivotal component of the molecular machinery that determines short-term synaptic plasticity characteristics.
The Munc13 gene family encodes molecules located at the synaptic active zone that regulate the reliability of synapses to encode information over a wide range of frequencies in response to action potentials.
This study demonistrated that Munc13 genotype regulates secretory amyloid precursor protein (zeige APP Antikörper) processing via postsynaptic glutamate (zeige GRIN1 Antikörper) receptors
Mammalian homologue of Caenorhabditis elegans unc-13-1 (Munc13-1 (zeige UNC13A Antikörper)) plays a role in the recruitment of newcomer insulin (zeige INS Antikörper) granules in both first and second phases of glucose-stimulated insulin (zeige INS Antikörper) secretion in mouse islets.
Chromaffin cell vesicle-priming by brain-specific ubMunc13 isoform 2 is calcium ion (Ca2+) dependent but independent of calmodulin binding to ubMunc13 isoform 2.
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
unc-13 homolog B (C. elegans)
, protein unc-13 homolog B
, protein unc-13 homolog B-like
, homolog of rat Munc13 (diacylglycerol-binding)
, UNC-13 homolog 1
, unc-13 homolog A
, unc13 homolog 1
, unc-13 B-like protein