anti-Mitofusin 2 (MFN2) Antikörper

Bezeichnung:
anti-Mitofusin 2 Antikörper (MFN2)
Auf www.antikoerper-online.de finden Sie aktuell 175 Mitofusin 2 (MFN2) Antikörper von 23 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Mitofusin 2 Proteine (10) und Mitofusin 2 Kits (7) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 202 Mitofusin 2 Produkte verfügbar.
Synonyme:
anon-WO0125274.3, CG3869, CMT2A, CMT2A2, CPRP1, D630023P19Rik, Dmel\\CG3869, dmfn, Fzo, HSG, marf, Marf-1, mfn, MFN2, mg:cb01g09, si:dkeyp-104h9.2, wu:fb79a11

Meistgesuchte Reaktivitäten zu anti-Mitofusin 2 (MFN2) Antikörper

Wählen Sie die Spezies und Applikation aus

anti-Human Antikörper:

anti-Mouse (Murine) Antikörper:

anti-Rat (Rattus) Antikörper:

Alle verfügbaren anti-Mitofusin 2 Antikörper

Sie gelangen zu unserer vorgefilterten Suche.

Am meisten referenzierte anti-Mitofusin 2 Antikörper

  1. Cow (Bovine) Polyclonal MFN2 Primary Antibody für IHC, WB - ABIN2775408 : Chung, Cho, Hwang, Kim, Yoo, Kwon, Kim, Sunwoo, Züchner, Choi: Early-onset stroke associated with a mutation in mitofusin 2. in Neurology 2008 (PubMed)
    Zeige alle 2 Referenzen für 2775408

  2. Human Polyclonal MFN2 Primary Antibody für IF (p), IHC (p) - ABIN682528 : Ku, Ji, Zhang, Li, Sang: PM2.5, SO2 and NO2 co-exposure impairs neurobehavior and induces mitochondrial injuries in the mouse brain. in Chemosphere 2016 (PubMed)
    Zeige alle 2 Referenzen für 682528

  3. Human Polyclonal MFN2 Primary Antibody für IHC, IHC (p) - ABIN4334778 : Yang, Yang: Bit-by-bit autophagic removal of parkin-labelled mitochondria. in Nature communications 2013 (PubMed)

  4. Human Monoclonal MFN2 Primary Antibody für IHC (p), ELISA - ABIN523306 : Stacchiotti, Favero, Giugno, Lavazza, Reiter, Rodella, Rezzani: Mitochondrial and metabolic dysfunction in renal convoluted tubules of obese mice: protective role of melatonin. in PLoS ONE 2014 (PubMed)

  5. Human Monoclonal MFN2 Primary Antibody für IHC (p), WB - ABIN2475579 : Minet, Gaster: The dynamic equilibrium between ATP synthesis and ATP consumption is lower in isolated mitochondria from myotubes established from type 2 diabetic subjects compared to lean control. in Biochemical and biophysical research communications 2011 (PubMed)

  6. Human Polyclonal MFN2 Primary Antibody für IHC (p), WB - ABIN568087 : Santel, Fuller: Control of mitochondrial morphology by a human mitofusin. in Journal of cell science 2001 (PubMed)

Weitere Antikörper gegen Mitofusin 2 Interaktionspartner

Fruit Fly (Drosophila melanogaster) Mitofusin 2 (MFN2) Interaktionspartner

  1. activation of endoplasmic reticulum stress by defective mitochondria is neurotoxic in pink1 (zeige PINK1 Antikörper) and parkin (zeige PARK2 Antikörper) flies and that the reduction of this signalling is neuroprotective, independently of defective mitochondria.

  2. Clu (zeige CLU Antikörper) is upstream of and binds to VCP (zeige vcp Antikörper) in vivo and promotes VCP (zeige vcp Antikörper)-dependent Marf degradation in vitro Marf accumulates in whole muscle lysates of clu (zeige CLU Antikörper)-deficient flies and is destabilized upon Clu (zeige CLU Antikörper) overexpression. Thus, Clu (zeige CLU Antikörper) is essential for mitochondrial homeostasis and functions in concert with Parkin (zeige PARK2 Antikörper) and VCP (zeige vcp Antikörper) for Marf degradation to promote damaged mitochondrial clearance.

  3. lack of ChChd3 (zeige CHCHD3 Antikörper) leads to inactivation of Hippo activity under normal development, which is also dependent on the transcriptional coactivator Yorkie (Yki (zeige YAP1 Antikörper)). Furthermore, loss of ChChd3 (zeige CHCHD3 Antikörper) induces oxidative stress and activates the JNK (zeige MAPK8 Antikörper) pathway. In addition, depletion of other mitochondrial fusion components, Opa1 (zeige OPA1 Antikörper) or Marf, inactivates the Hippo pathway as well.

  4. Marf is required for mitochondrial fusion and transport in long axons.

  5. Expression of Mfn2 and endoplasmic reticulum (ER) stress reduction in flies lacking Marf corrected ER shape, attenuating the developmental and motor defects.

  6. Parkin (zeige PARK2 Antikörper) deficiency and resulting mitophagic disruption produces cardiomyopathy which can be contained by suppressing mitofusin.

  7. mfn2 mutations alter mitochondrial dynamics and induce retinal and cardiac pathology

  8. Data report here that Drosophila Reaper can induce mitochondrial fragmentation by binding to and inhibiting the pro-fusion protein MFN2 and its Drosophila counterpart dMFN/Marf.

  9. MARF and Opa1 (zeige OPA1 Antikörper) control mitochondrial and cardiac function in Drosophila.

  10. The PINK1 (zeige PINK1 Antikörper)/Parkin (zeige PARK2 Antikörper) pathway affects mitochondrial fission/fusion as suggested by previous genetic interaction studies.

Human Mitofusin 2 (MFN2) Interaktionspartner

  1. MFN2 gene polymorphisms (rs873457, rs2336384, rs1474868, rs4846085 and rs2236055) may be associated with acute liver failure and the rs873457 and rs4846085 polymorphisms are correlated with the risk and prognosis of acute liver failure.

  2. SLC25A46 (zeige SLC25A46 Antikörper) is a new component in mitochondrial dynamics that serves as a regulator for MFN1 (zeige MFN1 Antikörper)/2 oligomerization.

  3. Presenilin 2 (PS2 (zeige PSEN2 Antikörper)), mutations in which underlie familial Alzheimer's disease (FAD (zeige BRCA2 Antikörper)), promotes endoplasmic reticulum-mitochondria coupling only in the presence of mitofusin 2 (Mfn2).

  4. PGC-1alpha (zeige PPARGC1A Antikörper) enhances Mfn2 transcription, but also leads to increased degradation of the Mfn2 protein, a key ubiquitylation target of Parkin (zeige PARK2 Antikörper) on mitochondria. In vivo, Parkin (zeige PARK2 Antikörper) has significant protective effects on the survival and function of nigral dopaminergic neurons in which the chronic expression of PGC-1alpha (zeige PPARGC1A Antikörper) is induced

  5. Exome sequencing identified MFN2 SNVs in two of the individuals. Neuropathy-associated CNV outside of the PMP22 (zeige PMP22 Antikörper) locus is rare in Charcot-Marie-Tooth (CMT) disease . Nevertheless, there is potential clinical utility in testing for CNVs and exome sequencing in CMT cases negative for the CMT1A (zeige PMP22 Antikörper) duplication.

  6. Smad2 (zeige SMAD2 Antikörper) is a key scaffold, allowing RIN1 (zeige RIN1 Antikörper) to act as a GTP (zeige AK3 Antikörper) exchange factor for MFN2-GTPase (zeige RACGAP1 Antikörper) activation to promote mitochondrial ATP synthesis and suppress superoxide production during mitochondrial fusion.

  7. our results suggest that KAP1 (zeige CDKN3 Antikörper) Ser473 phosphorylation acts through MFN2 reduction to restrict mitochondrial hyperfusion, thereby contributing to cancer cell survival under conditions of sustained metabolic stress

  8. Mfn2 downregulation or the exogenous expression of normal Parkin (zeige PARK2 Antikörper) restored cytosolic Ca(2 (zeige CA2 Antikörper)+) transients in fibroblasts from patients with PARK2 (zeige PARK2 Antikörper) mutations, a catalytically inactive Parkinson's disease (PD)-related Parkin (zeige PARK2 Antikörper) variant had no effect. Parkin (zeige PARK2 Antikörper) is directly involved in regulating ER-mitochondria contacts and provide new insight into the role of the loss of Parkin (zeige PARK2 Antikörper) function in PD development

  9. siRNA knockdown of mitofusin-2 (Mfn2), a protein that is involved in the tethering of endoplasmic reticulum and mitochondria, leads to increased contact between the two organelles.

  10. Taken together, these data suggest that the striking reduction in mitochondria in MNs (zeige FLNA Antikörper) expressing mutant MFN2 is not the result of impaired biogenesis, but more likely the consequence of enhanced mitophagy.

Mouse (Murine) Mitofusin 2 (MFN2) Interaktionspartner

  1. Presenilin 2 (PS2 (zeige PSEN2 Antikörper)), mutations in which underlie familial Alzheimer's disease (FAD (zeige FANCD2 Antikörper)), promotes endoplasmic reticulum-mitochondria coupling only in the presence of mitofusin 2 (Mfn2).

  2. The data of this study suggest that post-translational modification of Mfn2 is associated with its dysregulation during a window of metabolic vulnerability that precedes glaucomatous degeneration.

  3. Study demonstrated that deregulation of mfn2 played a critical role in the mitochondrial disorder during the progression of Alzheimer's disease, and its decreased expression was regulated at least in part by miR (zeige MLXIP Antikörper)-195. Therefore, upregulation of mfn2 expression by decreasing the level of miR (zeige MLXIP Antikörper)-195 might be a potential new therapeutic strategy for treatment of Alzheimer's disease.

  4. Mfn2 downregulation or the exogenous expression of normal Parkin (zeige PARK2 Antikörper) restored cytosolic Ca(2 (zeige CA2 Antikörper)+) transients in fibroblasts from patients with PARK2 (zeige PARK2 Antikörper) mutations, a catalytically inactive Parkinson's disease (PD)-related Parkin (zeige PARK2 Antikörper) variant had no effect. Parkin (zeige PARK2 Antikörper) is directly involved in regulating ER-mitochondria contacts and provide new insight into the role of the loss of Parkin (zeige PARK2 Antikörper) function in PD development.

  5. Altogether, these results demonstrate that Mfn2 is a mediator of mitochondria to lipid droplet interactions, influencing lipolytic processes and whole-body energy homeostasis.

  6. we demonstrated that by modulating mitochondrial energy metabolism through Mfn2 and mitochondrial Ca2 (zeige CA2 Antikörper)+, PPAR-b (zeige PPARD Antikörper) took an important role in neuronal differentiation induced by flavonoid compound 4a

  7. Furthermore, analysis of muscle Mfn2-deficient mice revealed that aging-induced Mfn2 decrease underlies the age-related alterations in metabolic homeostasis and sarcopenia.

  8. Mice hemizygous for a pathogenic Mfn2 allele exhibit hind limb/foot gait deficits and phenotypic perturbations in nerve and muscle.

  9. We found that mouse embryonic fibroblasts lacking Mfn2 have altered lipid droplet morphology. However, triacylglycerol biosynthesis was not dependent on ER-mitochondrial tethering mediated by mitofusins. Lastly, Mfn2 does not have a role in adipocyte differentiation.

  10. knockdown of Mfn2 in adipo and osteogenesis and the overexpression of a dominant negative form of Drp1 (zeige CRMP1 Antikörper) during chondrogenesis resulted in a loss of differentiation ability

Zebrafish Mitofusin 2 (MFN2) Interaktionspartner

  1. These results highlight the essential role of mitofusin 2 in the motor axon development and demonstrate the potential of zebrafish as a suitable and complementary platform for dissecting pathogenetic mechanisms of MFN2 mutations in vivo.

Cow (Bovine) Mitofusin 2 (MFN2) Interaktionspartner

  1. A highly unusual splicing defect, where an exonic single base exchange leads to the retention of the preceding intron, was identified in MFN2 (zeige MFN1 Antikörper).

Mitofusin 2 (MFN2) Antigen-Profil

Beschreibung des Gens

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

Alternative names and synonyms associated with Mitofusin 2 (MFN2)

  • mitofusin 2 (MFN2) Antikörper
  • Mitochondrial assembly regulatory factor (Marf) Antikörper
  • mitofusin 2 (mfn2) Antikörper
  • mitofusin 2 (Mfn2) Antikörper
  • mitofusin 2 (LOC100350119) Antikörper
  • anon-WO0125274.3 Antikörper
  • CG3869 Antikörper
  • CMT2A Antikörper
  • CMT2A2 Antikörper
  • CPRP1 Antikörper
  • D630023P19Rik Antikörper
  • Dmel\\CG3869 Antikörper
  • dmfn Antikörper
  • Fzo Antikörper
  • HSG Antikörper
  • marf Antikörper
  • Marf-1 Antikörper
  • mfn Antikörper
  • MFN2 Antikörper
  • mg:cb01g09 Antikörper
  • si:dkeyp-104h9.2 Antikörper
  • wu:fb79a11 Antikörper

Bezeichner auf Proteinebene für anti-Mitofusin 2 (MFN2) Antikörper

CG3869-PA , CG3869-PB , CG3869-PC , Marf-PA , Marf-PB , Marf-PC , drosophila mitofusin , mitochondrial assembly regulatory factor , mitofusin , mitofusin 2 , mitofusin-2 , mitofusin-2-like , hyperplasia suppressor , transmembrane GTPase MFN2 , HSG protein , hypertension related protein 1 , hypertension-related protein 1 , hypertension-related protein , mitochondrial transmembrane GTPase FZO1A

GENE ID SPEZIES
100055966 Equus caballus
31581 Drosophila melanogaster
457958 Pan troglodytes
549268 Xenopus (Silurana) tropicalis
100172672 Pongo abelii
100186475 Ciona intestinalis
100427191 Macaca mulatta
100470367 Ailuropoda melanoleuca
100599174 Nomascus leucogenys
9927 Homo sapiens
170731 Mus musculus
64476 Rattus norvegicus
567448 Danio rerio
431918 Xenopus laevis
419484 Gallus gallus
487439 Canis lupus familiaris
534574 Bos taurus
100350119 Oryctolagus cuniculus
100512172 Sus scrofa
Ausgewählte Anbieter für anti-Mitofusin 2 (MFN2) Antikörper
Haben Sie etwas anderes gesucht?