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Human Thymidine Phosphorylase ELISA Kit für Sandwich ELISA - ABIN414766
Laudanski, Charkiewicz, Kuzmicki, Szamatowicz, ?wi?tecka, Mroczko, Niklinski: Profiling of selected angiogenesis-related genes in proliferative eutopic endometrium of women with endometriosis. in European journal of obstetrics, gynecology, and reproductive biology 2013
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TP(thymidine phosphorylase ) curbed the expression of three proteins-IRF8 (zeige IRF8 ELISA Kits), RUNX2 (zeige RUNX2 ELISA Kits), and osterix (zeige SP7 ELISA Kits). This downregulation was epigenetically driven: High levels of 2DDR, a product of TP secreted by myeloma cells, activated PI3K (zeige PIK3CA ELISA Kits)/AKT (zeige AKT1 ELISA Kits) signaling and increased the methyltransferase DNMT3A's expression
These findings are consistent with a model in which signalling via S1P (zeige MBTPS1 ELISA Kits) and S1PR1 (zeige S1PR1 ELISA Kits) are integral components in the response of lymphatic endothelial cells to the stimulus provided by fluid flow.
S1PR1 (zeige S1PR1 ELISA Kits)/3 silencing alters proliferation, adhesion, viability and lateral motility in estrogen receptor (zeige ESR1 ELISA Kits)-negative MCF-7 and estrogen receptor (zeige ESR1 ELISA Kits)-positive MDA-MB-231 breast cancer cells.
TP expression is associated with tumor stage, histological grade and thrombocytosis in patients with renal cell carcinoma
Activated S1PR1 (zeige S1PR1 ELISA Kits) signaling regulates the production of cellular adhesion molecules by inhibiting NF- kappaB (zeige NFKB1 ELISA Kits) activation via a beta (zeige SUCLA2 ELISA Kits)-arrestin2 (zeige ARRB2 ELISA Kits)-dependent manner
Studied the role of thymidine phosphorylase (TP) in promoting the invasion and metastasis of hepatocellular carcinoma (HCC (zeige FAM126A ELISA Kits)). It was shown that TP correlated with MMP2 (zeige MMP2 ELISA Kits) and MMP9 (zeige MMP9 ELISA Kits) expression, and that TP mediated the migration of tumor cells through activity of MMPs in HCC (zeige FAM126A ELISA Kits) cell lines.
Model recombinant HDL (zeige HSD11B1 ELISA Kits) (rHDL) particles formed in vitro with S1P (zeige MBTPS1 ELISA Kits) incorporated into the particle initiated the internalization of S1PR1 (zeige S1PR1 ELISA Kits), whereas rHDL without supplemented S1P (zeige MBTPS1 ELISA Kits) did not, suggesting that S1P (zeige MBTPS1 ELISA Kits) transported in HDL (zeige HSD11B1 ELISA Kits) can selectively activate S1PR1 (zeige S1PR1 ELISA Kits).
Blocking of S1PR activity and inhibition of S1P (zeige MBTPS1 ELISA Kits) synthesis led to decreased expression of fibrosis and tissue remodeling-related proteins in primary cultures of orbital fibroblasts derived from patients with GO.
a lipid molecule repeatedly entered the receptor between the extracellular ends of TM1 (zeige TPM2 ELISA Kits) and TM7, providing important insights into the pathway of ligand entry into the S1PR1 (zeige S1PR1 ELISA Kits) .
Mature human thymocytes rely on S1P (zeige MBTPS1 ELISA Kits)-R1 to migrate toward S1P (zeige MBTPS1 ELISA Kits). Taken in the context of murine work demonstrating that S1P (zeige MBTPS1 ELISA Kits) is required for thymocyte egress to the periphery.
data identify TYMP as an astrocyte-derived permeability factor, and suggest TYMP and VEGFA (zeige VEGFA ELISA Kits) together promote blood-brain barrier breakdown.
TYMP participates in multiple platelet signaling pathways and regulates platelet activation and thrombosis. Targeting TYMP might be a novel antiplatelet and antithrombosis therapy.
Thymidine phosphorylase and UPP1 (zeige UPP1 ELISA Kits) double knockout mice showed increased thymidine and deoxyuridine in tissues and developed encephalopathy.
This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified.
, endothelial cell growth factor 1 (platelet-derived)
, platelet derived growth factor, endothelial cell
, thymidine phosphorylase
, Thymidine phosphorylase