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anti-Human EPAS1 Antikörper:
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Fish Polyclonal EPAS1 Primary Antibody für ChIP, ELISA - ABIN151051
Conrad, Freeman, Beitner-Johnson, Millhorn: EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. in The Journal of biological chemistry 1999
Show all 478 Pubmed References
Hamster Monoclonal EPAS1 Primary Antibody für ChIP, ELISA - ABIN151063
Bernhardt, Wiesener, Weidemann, Schmitt, Weichert, Lechler, Campean, Ong, Willam, Gretz, Eckardt: Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. in The American journal of pathology 2007
Show all 146 Pubmed References
Hamster Monoclonal EPAS1 Primary Antibody für ELISA, IHC - ABIN250056
Harvey, Kind, Pantaleon, Armstrong, Thompson: Oxygen-regulated gene expression in bovine blastocysts. in Biology of reproduction 2004
Show all 19 Pubmed References
Hamster Monoclonal EPAS1 Primary Antibody für ELISA, ICC - ABIN250055
Mekhail, Gunaratnam, Bonicalzi, Lee: HIF activation by pH-dependent nucleolar sequestration of VHL. in Nature cell biology 2004
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Fish Polyclonal EPAS1 Primary Antibody für ELISA, ICC - ABIN249868
Alvarez-Tejado, Naranjo-Suarez, Jiménez, Carrera, Landázuri, del Peso: Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. in The Journal of biological chemistry 2001
Show all 17 Pubmed References
Human Monoclonal EPAS1 Primary Antibody für IHC (fro), IHC (p) - ABIN1742588
Wiesener, Turley, Allen, Willam, Eckardt, Talks, Wood, Gatter, Harris, Pugh, Ratcliffe, Maxwell: Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. in Blood 1998
Show all 4 Pubmed References
Hamster Monoclonal EPAS1 Primary Antibody für ELISA, FACS - ABIN406865
Su, Li, Cui, Ji, Geng, Chai, Ma, Bai, Yang, Wuren, Ge, Rondina: The Local HIF-2α/EPO Pathway in the Bone Marrow is Associated with Excessive Erythrocytosis and the Increase in Bone Marrow Microvessel Density in Chronic Mountain Sickness. in High altitude medicine & biology 2015
Human Monoclonal EPAS1 Primary Antibody für AA, ELISA - ABIN863099
Kim, Perera, Zhou, Carretero, Yeh, Heathcote, Jackson, Nikolinakos, Ospina, Naumov, Brandstetter, Weigman, Zaghlul, Hayes, Padera, Heymach, Kung, Sharpless, Kaelin, Wong: HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. in The Journal of clinical investigation 2009
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Human Polyclonal EPAS1 Primary Antibody für IF (p), IHC (p) - ABIN686662
Li, Chen, Shao, Tang, Chen, Chen, Xu: Oxidative stress induces the decline of brain EPO expression in aging rats. in Experimental gerontology 2016
Human Monoclonal EPAS1 Primary Antibody für IHC (p) - ABIN2473999
Pike, Phadwal, Simon, Harris: ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia. in Molecular biology reports 2012
Over-expression of HIF-2alpha induced apoptosis in HCC (zeige FAM126A Antikörper) cells and increased the levels of pro-apoptotic proteins, Bak (zeige BAK1 Antikörper), ZBP-89 (zeige ZNF148 Antikörper) and PDCD4 (zeige PDCD4 Antikörper), whereas the inhibition of HIF-2alpha expression achieved opposite results. HIF-2alpha was decreased and played an anti-tumorigenic role in hepatocellular carcinoma.
Probiotic Bifidobacterium bifidum MIMBb75 may help attenuating EPAS1 overexpression associated with intestinal inflammation.
Data suggest that HIF2alpha mediates hypoxia-induced cancer growth/metastasis and that EFEMP1 (zeige FBLN3 Antikörper) is a downstream effector of hypoxia-induced HIF2alpha during breast tumorigenesis.
intestine HIF-2alpha regulates ceramide metabolism mainly from the salvage pathway, by positively regulating the expression of Neu3 (zeige Neu3 Antikörper), the gene encoding neuraminidase 3 (zeige Neu3 Antikörper). These results suggest that intestinal HIF-2alpha could be a viable target for hepatic steatosis therapy
demonstrated that MM cells are resistant to hypoxia-mediated apoptosis in vivo and in vitro, and that constitutive expression of HIF2alpha contributed to this resistance
HIF1A (zeige HIF1A Antikörper) and EPAS1 potentiate hypoxia-induced upregulation of INHA (zeige INHA Antikörper) expression in human term cytotrophoblasts in vitro.
Data show there was a significant negative correlation between PHGDH (zeige PHGDH Antikörper) copy-number alteration and EPAS1 (HIF2A) expression.
positive and bilateral HIF2-EGFR (zeige EGFR Antikörper) regulatory crosstalk promotes antiestrogen resistance in estrogen receptor alpha (zeige ESR1 Antikörper)-positive breast cancer
NAP peptide prevents outer blood retinal barrier breakdown by reducing HIF1alpha (zeige HIF1A Antikörper)/HIF2alpha, VEGF (zeige VEGFA Antikörper)/VEGFRs, and increasing HIF3alpha expression Moreover it is able to reduce the percentage of apoptotic cells by modulating the expression of two death related genes, BAX (zeige BAX Antikörper) and Bcl2 (zeige BCL2 Antikörper).
Data identify a previously unrecognized cellular process associated with hypoxia, and suggests that in vivo tumour hypoxia determines copper isotope fractionation in hepatocellular carcinoma and demonstrate that this effect of hypoxia is pH, HIF-1 (zeige HIF1A Antikörper) and -2 independent.
endothelial EPAS1 has a global protective role during glomerular hypertensive injuries without influencing the hypertensive effect of angiotensin II
findings indicate that HIF-2alpha increases cancer cell growth by up-regulating YAP1 (zeige YAP1 Antikörper) activity
Chronic activity of HIF2 in stromal progenitors impairs kidney development. Finally, these data confirm the concept that normal stroma function is essential for normal tubular differentiation.
this study shows that HIF-2alpha acts in resting macrophages as a phagocytosis suppressor implying an important relationship between the levels of HIF-2alpha and susceptibility to infection
in neurons HIF-1 (zeige HIF1A Antikörper) and HIF-2 have redundant functions for cellular survival under ischemic conditions. By contrast, lack of anti-survival factors in Hif1a (zeige HIF1A Antikörper)/Hif2a-deficient mice might protect from early acute neuronal cell death and neurological impairment, indicating a benefit of HIF-pathway inhibition in neurons in the very acute phase after ischemic stroke
HIF-2alpha is a novel regulator of neutrophil recruitment to colon tumors.
AQP1 (zeige AQP1 Antikörper) deficiency delays long-term ischemia-reperfusion resolution, partly through repressing angiogenesis mediated by destabilizing HIF-2alpha.
HIF1alpha (zeige HIF1A Antikörper) and HIF2alpha are dispensable for muscle stem cell function under normoxia but are required for maintaining satellite cell self-renewal in hypoxic environments.
eIF3e (zeige EIF3E Antikörper) is an angiogenesis suppressor. Silencing of eIF3e (zeige EIF3E Antikörper) promotes blood perfusion recovery after limb ischemia through stabilization of hypoxia-inducible factor 2alpha activity.
immunostaining for HIF-1alpha (zeige HIF1A Antikörper) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification
There was an association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with high altitude pulmonary hypertension (HAPH). There was upregulation of 26 of 27 HIF2alpha target genes in EPAS1 carriers with HAPH.
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
endothelial PAS domain protein 1
, endothelial PAS domain-containing protein 1-like
, HIF-1-alpha-like factor
, HIF-1alpha-like factor
, PAS domain-containing protein 2
, basic-helix-loop-helix-PAS protein MOP2
, class E basic helix-loop-helix protein 73
, endothelial PAS domain-containing protein 1
, hypoxia-inducible factor 2 alpha
, hypoxia-inducible factor 2-alpha
, member of PAS protein 2
, HIF-related factor
, HIF1 alpha-like factor
, HIF1alpha-like factor
, HLF (HIF1alpha-like factor)
, Hif like protein
, hypoxia inducible transcription factor 2alpha
, HIF-2 alpha
, HIF2 alpha
, hypoxia inducible factor 2, alpha subunit
, hypoxia inducible factor 2a