anti-Human Solute Carrier Family 26, Member 5 (Prestin) Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Recommended Solute Carrier Family 26, Member 5 (Prestin) Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5) Antikörper
  • pres
  • fb73d12
  • fb74g12
  • wu:fb73d12
  • wu:fb74g12
  • DFNB61
  • PRES
  • Pres
  • prestin
  • solute carrier family 26, member 5
  • solute carrier family 26, member 5 (prestin)
  • solute carrier family 26 (anion exchanger), member 5
  • slc26a5
  • SLC26A5
  • Slc26a5
Reaktivität
Human, Maus, Ratte (Rattus)
28
9
9
5
3
2
2
2
2
2
1
Wirt
Kaninchen
15
11
3
Klonalität
Polyklonal
Konjugat
Unkonjugiert
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
22
13
8
2
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Produktnummer ABIN748718
$ 295.90
Zzgl. Versandkosten $45.00

General

Antigen Solute Carrier Family 26, Member 5 (Prestin) (SLC26A5) Antikörper
Reaktivität Human, Maus, Ratte (Rattus)
(28), (9), (9), (5), (3), (2), (2), (2), (2), (2), (1)
Wirt Kaninchen
(15), (11), (3)
Klonalität
Polyklonal
Konjugat Unkonjugiert
(1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(22), (13), (8), (2)
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Slc26a5
Isotyp IgG

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung Slc26a5 (SLC26A5 Antibody Abstract)
Hintergrund

SLC26A5 (Solute carrier family 26, member 5) is specifically expressed in outer hair cells (OHCs) of the cochlea and is essential in auditory processing. It acts as a motor protein that converts auditory stimuli to length changes in outer hair cells. It is a bidirectional voltage-to-force converter which uses cytoplasmic anions as extrinsic voltage sensors. The anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. This translocation triggers conformational changes in the protein that alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). It acts as an incomplete transporter since it moves anions across the membrane, but does not allow the anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the anion-binding site. Mutations in SLC26A5 have been associated with non-syndromic hearing loss.

Subcellular location: Cytoplasm

Synonyms: Prestin, Deafness neurosensory autosomal recessive 61, DFNB 61, DFNB61, MGC118886, MGC118887, MGC118888, MGC118889, PRES, Prestin motor protein, Prestin, S26A5_HUMAN, SLC26A5, Solute carrier family 26 member 5 prestin, Solute carrier family 26 member 5.

Gen-ID 375611
Pathways Sensory Perception of Sound, Dicarboxylic Acid Transport

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Bilder zurück nach oben
Applikationshinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months