anti-Maus SIX Homeobox 1 Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended SIX Homeobox 1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
SIX Homeobox 1 (SIX1) Antikörper
  • BB138287
  • BOS3
  • DFNA23
  • TIP39
  • XSix1
  • sine oculis-related homeobox 1
  • SIX homeobox 1
  • Six1
  • SIX1
  • six1
Reaktivität
Human, Maus
35
18
8
4
4
4
3
3
3
2
1
1
1
1
Wirt
Kaninchen
26
10
Klonalität
Polyklonal
Applikation
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
28
15
5
4
3
2
1
Hersteller
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Bilder

Produktnummer ABIN4353939
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General

Antigen SIX Homeobox 1 (SIX1) Antikörper
Reaktivität Human, Maus
(35), (18), (8), (4), (4), (4), (3), (3), (3), (2), (1), (1), (1), (1)
Wirt Kaninchen
(26), (10)
Klonalität
Polyklonal
Applikation Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(28), (15), (5), (4), (3), (2), (1)
Pubmed 15 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Referenzen Bilder
Spezifität Specificity of antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
Reinigung Immunogen affinity purified
Immunogen This antibody was developed against Recombinant Protein corresponding to amino acids:CFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTENNNSSSNKQNQLSPLEGGKPLMSSSEEEFSPPQSPDQNSVLLLQGNMGHARSSNYSLPGLTASQPSHGLQTHQHQLQDS
Isotyp IgG

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Referenzen Bilder zurück nach oben
Antigen
Andere Bezeichnung SIX1 (SIX1 Antibody Abstract)
Hintergrund Gene Symbol: SIX1
Gen-ID 6495
UniProt Q15475
Forschungsgebiet Cell Cycle, Transcription Factors, Chromatin and Nuclear Signaling
Pathways Sensory Perception of Sound, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Referenzen Bilder zurück nach oben
Applikationshinweise Western Blot 1:100-1:500, Immunohistochemistry 1:10-1:500, Immunocytochemistry/Immunofluorescence 1 - 4 μg/mL, Immunohistochemistry-Paraffin 1:500-1:1000For IHC-Paraffin HIER pH 6 retrieval is recommended. IF fixation permeabilization: PFA/Triton X-100.
Kommentare

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Referenzen Bilder zurück nach oben
Format Liquid
Buffer PBS ( pH 7.2) and 40 % Glycerol
Buffer contains: 0.02 % Sodium Azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C,-20 °C
Informationen zur Lagerung Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Referenzen

Produktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Adrados, Larrasa-Alonso, Galarreta, López-Antona, Menéndez, Abad, Gil, Moreno-Bueno, Palmero: "The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes." in: Oncogene, Vol. 35, Issue 27, pp. 3485-94, 2016 (Probematerial (Species): Human). Weitere Details: Immunocytochemistry,Immunofluorescence

Kahlert, Lerbs, Pecqueux, Herpel, Hoffmeister, Jansen, Brenner, Chang-Claude, Bläker, Kloor, Roth, Pilarsky, Rahbari, Schölch, Bork, Reissfelder, Weitz, Aust, Koch: "Overexpression of SIX1 is an independent prognostic marker in stage I-III colorectal cancer." in: International journal of cancer, Vol. 137, Issue 9, pp. 2104-13, 2015 (Probematerial (Species): Human). Weitere Details: Immunohistochemistry (Paraffin-embedded Sections)

Towers, Guarnieri, Micalizzi, Harrell, Gillen, Kim, Wang, Oliphant, Drasin, Guney, Kabos, Sartorius, Tan, Perou, Espinosa, Ford: "The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p." in: Nature communications, Vol. 6, pp. 10077, 2015 (Probematerial (Species): Human). Weitere Details: Western Blotting

Iwanaga, Wang, Micalizzi, Harrell, Jedlicka, Sartorius, Kabos, Farabaugh, Bradford, Ford et al.: "Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated kinase and transforming growth ..." in: Breast cancer research : BCR, Vol. 14, Issue 4, pp. R100, 2014

Koehler, Hashino: "3D mouse embryonic stem cell culture for generating inner ear organoids." in: Nature protocols, Vol. 9, Issue 6, pp. 1229-44, 2014 Weitere Details: Immunohistochemistry

Sakakibara, Santolini, Ferry, Hakim, Maire: "Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype." in: PLoS genetics, Vol. 10, Issue 5, pp. e1004386, 2014 (Probematerial (Species): Mouse (Murine)). Weitere Details: Western Blotting,Chromatin Immunoprecipitation

Kong, Zhou, Liu, Jin, Piao, Liu, Lin: "Overexpression of sineoculis homeobox homolog 1 predicts poor prognosis of hepatocellular carcinoma." in: International journal of clinical and experimental pathology, Vol. 7, Issue 6, pp. 3018-27, 2014 (Probematerial (Species): Human). Weitere Details: Immunocytochemistry,Western Blotting,Immunofluorescence

Jefferson, Chevalier, Phelps, Cantor, Padilla-Banks, Newbold, Archer, Kinyamu, Williams: "Persistently altered epigenetic marks in the mouse uterus after neonatal estrogen exposure." in: Molecular endocrinology (Baltimore, Md.), Vol. 27, Issue 10, pp. 1666-77, 2013 (Probematerial (Species): Human). Weitere Details: Immunohistochemistry

Ono, Imoto, Kozaki, Tsuda, Matsui, Kurasawa, Muramatsu, Sugihara, Inazawa: "SIX1 promotes epithelial-mesenchymal transition in colorectal cancer through ZEB1 activation." in: Oncogene, Vol. 31, Issue 47, pp. 4923-34, 2012

Smith, Iwanaga, Drasin, Micalizzi, Vartuli, Tan, Ford: "The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer." in: Oncogene, Vol. 31, Issue 50, pp. 5162-71, 2012

Le Grand, Grifone, Mourikis, Houbron, Gigaud, Pujol, Maillet, Pagès, Rudnicki, Tajbakhsh, Maire: "Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration." in: The Journal of cell biology, Vol. 198, Issue 5, pp. 815-32, 2012

Farabaugh, Micalizzi, Jedlicka, Zhao, Ford: "Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties." in: Oncogene, Vol. 31, Issue 5, pp. 552-62, 2012

McCoy, Iwanaga, Jedlicka, Abbey, Chodosh, Heichman, Welm, Ford: "Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition." in: The Journal of clinical investigation, Vol. 119, Issue 9, pp. 2663-77, 2009

Micalizzi, Christensen, Jedlicka, Coletta, Barón, Harrell, Horwitz, Billheimer, Heichman, Welm, Schiemann, Ford: "The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling." in: The Journal of clinical investigation, Vol. 119, Issue 9, pp. 2678-90, 2009

Wan, Miao, Quraishi, Kennedy, Creek, Pirisi: "Gene expression changes during HPV-mediated carcinogenesis: a comparison between an in vitro cell model and cervical cancer." in: International journal of cancer, Vol. 123, Issue 1, pp. 32-40, 2008

Bilder

Produktdetails Antigendetails Anwendungsinformationen Handhabung Referenzen zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-SIX Homeobox 1 (SIX1) antibody (ABIN4353939) Western Blot: SIX1 Antibody [NBP1-84264] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55,...
Western Blotting (WB) image for anti-SIX Homeobox 1 (SIX1) antibody (ABIN4353939) Western Blot: SIX1 Antibody [NBP1-84264] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55,...
Western Blotting (WB) image for anti-SIX Homeobox 1 (SIX1) antibody (ABIN4353939) Western Blot: SIX1 Antibody [NBP1-84264] - Lane 1: NIH-3T3 cell lysate (Mouse embryon...
Immunofluorescence (IF) image for anti-SIX Homeobox 1 (SIX1) antibody (ABIN4353939) Immunocytochemistry/Immunofluorescence: SIX1 Antibody [NBP1-84264] - Staining of huma...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-SIX Homeobox 1 (SIX1) antibody (ABIN4353939) Immunohistochemistry-Paraffin: SIX1 Antibody [NBP1-84264] - Immunohistochemical stain...
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) image for anti-SIX Homeobox 1 (SIX1) antibody (ABIN4353939) Immunohistochemistry-Paraffin: SIX1 Antibody - Staining of human skeletal muscle sho...
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) image for anti-SIX Homeobox 1 (SIX1) antibody (ABIN4353939) Immunohistochemistry-Paraffin: SIX1 Antibody - Staining of human liver shows no posi...
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) image for anti-SIX Homeobox 1 (SIX1) antibody (ABIN4353939) Immunohistochemistry-Paraffin: SIX1 Antibody - Staining of human breast cancer shows...
Immunofluorescence (IF) image for anti-SIX Homeobox 1 (SIX1) antibody (ABIN4353939) Immunocytochemistry/Immunofluorescence: SIX1 Antibody - Staining of human cell line ...
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) image for anti-SIX Homeobox 1 (SIX1) antibody (ABIN4353939) Immunohistochemistry-Paraffin: SIX1 Antibody - Staining of human salivary gland show...