anti-Rind (Kuh) Norrie Disease (Pseudoglioma) Antikörper für Western Blotting

Recommended Norrie Disease (Pseudoglioma) Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Norrie Disease (Pseudoglioma) (NDP) Antikörper
  • EVR2
  • FEVR
  • ND
  • evr2
  • fevr
  • xnorrin
  • Ndph
  • RGD1563968
  • Norrie disease (pseudoglioma)
  • Norrie disease (pseudoglioma) (human)
  • NDP
  • ndp
  • Ndp
Epitop
Middle Region
8
7
2
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus)
30
8
6
Wirt
Kaninchen
27
4
Klonalität
Polyklonal
Konjugat
Unkonjugiert
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
23
11
10
10
5
4
3
3
2
1
Optionen
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Bilder

Produktnummer ABIN2786504
$ 289.00
Zzgl. Versandkosten $45.00

General

Antigen Norrie Disease (Pseudoglioma) (NDP) Antikörper
Epitop Middle Region
(8), (7), (2), (1)
Reaktivität Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus)
(30), (8), (6)
Wirt Kaninchen
(27), (4)
Klonalität
Polyklonal
Konjugat Unkonjugiert
(1), (1), (1), (1), (1)
Applikation Immunohistochemistry (IHC), Western Blotting (WB)
(23), (11), (10), (10), (5), (4), (3), (3), (2), (1)
Pubmed 1 Publikation vorhanden
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Produktdetails

Antigendetails Anwendungsinformationen Handhabung Referenzen Bilder
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN980552.
Sequenz DPRRCMRHHY VDSISHPLYK CSSKMVLLAR CEGHCSQASR SEPLVSFSTV
Homologie Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
Produktmerkmale This is a rabbit polyclonal antibody against NDP. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human NDP

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Referenzen Bilder zurück nach oben
Antigen
Andere Bezeichnung NDP (NDP Antibody Abstract)
Hintergrund NDP activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. NDP plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. NDP acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). NDP may be involved in a pathway that regulates neural cell differentiation and proliferation. NDP is the genetic locus identified as harboring mutations that result in Norrie disease. Norrie disease is a rare genetic disorder characterized by bilateral congenital blindness that is caused by a vascularized mass behind each lens due to a maldeveloped retina (pseudoglioma). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-94 AL034370.1 53727-53820 c 95-1761 X65882.1 1-1667 1762-1935 BE139596.1 1-174 c
Alias Symbols: EVR2, FEVR, ND
Protein Interaction Partner: FZD4, NDP, BAG3, APP, LGALS8, PPP1CA,
Protein Size: 133
Molekulargewicht 15 kDa
Gen-ID 4693
NCBI Accession NM_000266, NP_000257
UniProt Q00604
Forschungsgebiet Stem Cells, Wnt
Pathways Sensory Perception of Sound

Anwendungsinformationen

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Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 133 AA

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

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Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen

Produktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Khan, Aldahmesh, Meyer: "Correlation of ophthalmic examination with carrier status in females potentially harboring a severe Norrie disease gene mutation." in: Ophthalmology, Vol. 115, Issue 4, pp. 730-3, 2008

Bilder

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Bilder des Herstellers
Western Blotting (WB) image for anti-Norrie Disease (Pseudoglioma) (NDP) (Middle Region) antibody (ABIN2786504) WB Suggested Anti-NDP Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1...
Immunohistochemistry (IHC) image for anti-Norrie Disease (Pseudoglioma) (NDP) (Middle Region) antibody (ABIN2786504) Immunohistochemistry with Brain, cortex tissue at an antibody concentration of 5µg/ml...