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HOXA1-mediated activation of NF-kappaB (zeige NFKB1 ELISA Kits) is non-transcriptional and the RBCK1 (zeige RBCK1 ELISA Kits) and TRAF2 (zeige TRAF2 ELISA Kits) influences on NF-kappaB (zeige NFKB1 ELISA Kits) are epistatic to HOXA1
Overexpression of the HOXA1 expression is associated with increased transformation of myelodysplastic syndrome into acute myeloid leukemia (zeige BCL11A ELISA Kits).
Data indicated that HOXA1 and CCND1 (zeige CCND1 ELISA Kits) mRNA and protein expression were higher in gastric cancer (GC) tissues, that a significant correlation was found between their expression, and they both may serve as a novel prognostic biomarker for GC.
MicroRNA-99a inhibits tumor aggressive phenotypes through regulating HOXA1 in breast cancer cells.
In a Middle Eastern population, HOXA1 is not likely a common cause of non-syndromic deafness.
our findings suggest that HOXA1 is involved in the regulation of prostate cancer progression, including cell growth, migration, invasion and metastasis
Studied HOTAIR in chemoresistance of SCLC and possible molecular mechanism. Knockdown of HOTAIR was carried out in SCLC multidrug-resistant cell lines; found depletion of HOTAIR reduced HOXA1 methylation by decreasing DNMT1 (zeige DNMT1 ELISA Kits) & DNMT3b (zeige DNMT3B ELISA Kits) expression.
YAP regulates the expression of HOXA1 and HOXC13 in human keratinocytes.
Analysis indicates that the genes BIRC5 (zeige BIRC5 ELISA Kits), HOXA1 and RARB (zeige RARB ELISA Kits) are critical targets that play an important regulatory role in cervical cancer pathogenesis.
ACK1 (zeige TNK2 ELISA Kits) interacts with KDM3A (zeige KDM3A ELISA Kits) to regulate the mammary tumor oncogene (zeige RAB1A ELISA Kits) HOXA1.
When Hoxa1, Hoxb1 (zeige HOXB1 ELISA Kits) and Hoxd1 (zeige HOXD1 ELISA Kits) are knocked down in combination, the hindbrain patterning phenotype is more severe than in the single or double knockdowns
Authors found evidence for a high degree of evolutionary conservation of many binding regions and downstream targets of Hoxa1 between mouse and zebrafish.
Data indicate that homeobox A1 (HOXA1) was a direct microRNA miR (zeige MLXIP ELISA Kits)-30b target in esophageal cancer (EC) cells.
In presence of these inducing agents, lipid accumulation as well as expression of HoxA1, HoxA5 (zeige HOXA5 ELISA Kits), HoxC4 (zeige HOXC4 ELISA Kits) &HoxC8 (zeige HOXC8 ELISA Kits) markedly enhanced. Irrespective of presence or absence of T3, insulin (zeige INS ELISA Kits) down regulates HoxA10 (zeige HOXA10 ELISA Kits). T3 results in over expression of HoxA5 (zeige HOXA5 ELISA Kits), HoxC4 (zeige HOXC4 ELISA Kits) and HoxC8 (zeige HOXC8 ELISA Kits) genes, whereas insulin (zeige INS ELISA Kits) up regulates expression of only HoxC8 (zeige HOXC8 ELISA Kits)
These data suggest that Hoxb1 (zeige HOXB1 ELISA Kits) and Hoxa1 are more phenotypically divergent than previously reported and support that sub- and/or neofunctionalization has occurred in these paralogous genes leading to a divergence of gene function and incomplete redundancy
YAP regulates the expression of Hoxa1 and Hoxc13 in oral and dental epithelial tissues as well as in the epidermis of skin during embryonic and adult stages.
Many Hoxa1 interactors are proteins involved in cell-signaling transduction, cell adhesion and vesicular trafficking.
Hoxa1 null mice show defects such as interrupted aortic arch, aberrant subclavian artery and Tetralogy of Fallot mimic the defects in HoxA1 syndrome patients.
Hoxa1 acts in a genetic cascade upstream of genes controlling specific aspects of embryonic development.
Hoxa1 lineage tracing uncovered new domains of Hoxa1 expression in rhombomere 3, the otic epithelium, and cardiac precursors, suggesting a more direct role for Hoxa1 in development of these tissues than previously believed.
HOXA1 is a mammary epithelial oncogene (zeige RAB1A ELISA Kits) with aggressive in vivo tumor formation
Data suggest that, in developing gastrula, Znfl1 controls developmental gene expression of Hoxb1b in embryonic posterior neuroectoderm by acting upstream of Pou5f3 and Sall4 (zeige SALL4 ELISA Kits); these proteins appear to be involved in neurogenesis. (Znfl1 = zinc finger-like gene 1; Hoxb1b = homeobox B1b protein; Pou5f3 = POU domain class 5 transcription factor 3 (zeige TCF3 ELISA Kits); Sall4 (zeige SALL4 ELISA Kits) = spalt (zeige SALL1 ELISA Kits)-like transcription factor 4 (zeige TCF4 ELISA Kits))
Data indicate that hox genes hoxb1a and hoxb1b have separate functions in hindbrain development.
Hoxb1b regulates mitotic spindle rotation during the oriented neural keel symmetric mitoses that are required for normal neural tube lumen formation in the zebrafish.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region.
HOX A1 homeodomain protein
, Hox 1.6-like protein
, homeo box A1
, homeobox 1F
, homeobox protein Hox-1F
, homeobox protein Hox-A1
, lab-like protein
, homeobox A1
, homeobox A1, isoform 1
, early retinoic acid 1
, homeobox protein Hox-1.6
, homeoboxless protein ERA-1-399
, homeotic protein ERA-1-993
, homeobox protein
, homeobox b1b
, homeobox gene A-1
, homeobox protein Hox-B1b