Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog Proteine (FGR)

Auf www.antikoerper-online.de finden Sie aktuell 14 Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) Proteine von 9 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog Antikörper (132) und Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog Kits (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 161 Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog Produkte verfügbar.
Synonyme:
c-fgr, c-src2, p55-Fgr, p55c-fgr, p58-Fgr, p58c-fgr, SRC2
alle Proteine anzeigen Gen GeneID UniProt
FGR 79114 Q04589
FGR 2268 P09769
FGR 14191 P14234

Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog Proteine (FGR) nach Spezies

Weitere Proteine zu Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog Interaktionspartnern

Human Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) Interaktionspartner

  1. we provide evidence for involvement of HCK (zeige HCK Proteine) and FGR in FCRL4 (zeige FCRL4 Proteine)-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 (zeige FCRL4 Proteine) molecule.

  2. Data indicate that combined treatment using SFK (LYN (zeige LYN Proteine), HCK (zeige HCK Proteine), or FGR) and c-KIT inhibitor dasatinib dasatinib and chemotherapy provides a novel approach to increasing p53 (zeige TP53 Proteine) activity and enhancing targeting of acute myeloid leukemia (zeige BCL11A Proteine) (AML (zeige RUNX1 Proteine)) stem cells.

  3. Fgr plays a biologically significant role in ovarian cancer growth and might represent an important target

  4. Recruitment of the coactivator, SRC2 (zeige NCOA2 Proteine), is coupled to cooperative DNA binding by the progesterone receptor (zeige PGR Proteine).

Mouse (Murine) Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) Interaktionspartner

  1. the Hck, Fgr and Lyn kinases are also necessary for amastigote uptake by macrophages. Src-mediated Arg activation is required for efficient uptake.

  2. Data indicate that Src (zeige SRC Proteine)-Family Kinases Hck (zeige HCK Proteine) and Fgr regulate cytokine secretion by macrophages.

  3. Fgr is not only are progressively overexpressed in atherosclerosis, but it also controls critical molecular processes in monocyte influx, blood monocyte subset balance, macrophage accumulation, and the maintenance of atherosclerotic lesion stability.

  4. Ablation of Fgr abolishes the capacity of mitochondria to adjust metabolism upon nutrient restriction, hypoxia/reoxygenation, and T cell activation, demonstrating the physiological relevance of this adaptive response.

  5. The Src (zeige SRC Proteine) family kinases Hck (zeige HCK Proteine), Fgr, and Lyn (zeige LYN Proteine) are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.

  6. The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice.

  7. Despite possessing enhanced killing, alveolar macrophage Fgr/Hck (zeige HCK Proteine)/Lyn (zeige LYN Proteine)-deficient ("triple-knockout") mice do not demonstrate enhanced inflammatory responses to Pneumocystis murina.

  8. Hck and Fgr function as negative regulators of myeloid cell chemokine signaling by maintaining the tonic phosphorylation of PIR-

  9. interaction of MIST (zeige CLNK Proteine) with Fgr, mediated by the C-terminal proline-rich region of MIST (zeige CLNK Proteine) and the SH3 domain of Fgr, was required for the suppression of NK-cell receptor (zeige KLRD1 Proteine)-induced IFN-gamma (zeige IFNG Proteine) production

  10. Fgr plays no role in chemoattractant-induced, inside-out beta 2 integrin activation of neutrophils but regulates their outside-in, signaling-dependent sustained adhesion.

Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) Protein Überblick

Protein Überblick

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Alternative names and synonyms associated with Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR)

  • Fibroblast growth factor receptor 1 (Fgfr1)
  • Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog (FGR)
  • feline Gardner-Rasheed sarcoma viral oncogene (Fgr)
  • feline Gardner-Rasheed sarcoma viral oncogene homolog (FGR)
  • Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog (Fgr)
  • c-fgr Protein
  • c-src2 Protein
  • p55-Fgr Protein
  • p55c-fgr Protein
  • p58-Fgr Protein
  • p58c-fgr Protein
  • SRC2 Protein

Bezeichner auf Proteinebene für FGR

FGF receptor-1 , FGFR-1 , MFR , bFGF-R , bFGF-R-1 , basic fibroblast growth factor receptor 1 , c-fgr , fibroblast growth factor receptor 1 , proto-oncogene c-Fgr , tyrosine-protein kinase Fgr , proto-oncogene tyrosine-protein kinase FGR , Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog , tyrosine-protein kinase Fgr-like , Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog , proto-oncogene tyrosine-protein kinase Fgr , c-fgr protooncogene , c-src-2 proto-oncogene , p55-c-fgr protein , v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog , p55-Fgr

GENE ID SPEZIES
79114 Rattus norvegicus
516133 Bos taurus
716296 Macaca mulatta
739516 Pan troglodytes
100442468 Pongo abelii
100467541 Ailuropoda melanoleuca
79113 Rattus norvegicus
2268 Homo sapiens
14191 Mus musculus
487341 Canis lupus familiaris
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