anti-Rind (Kuh) COL4a3 Antikörper für Western Blotting

Recommended COL4a3 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Collagen, Type IV, alpha 3 (COL4a3) Antikörper
  • zTumstatin
  • [a]3(IV)
  • alpha3(IV)
  • collagen, type IV, alpha 3 (Goodpasture antigen)
  • collagen, type IV, alpha 3
  • COL4A3
  • col4a3
  • Col4a3
Epitop
Middle Region
8
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Schwein, Kaninchen, Ratte (Rattus)
59
28
18
3
3
2
2
1
1
1
1
1
Wirt
Kaninchen
55
4
Klonalität
Polyklonal
Konjugat
Dieser COL4a3 Antikörper ist unkonjugiert
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
30
22
16
13
6
4
2
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN2788301
$ 289.00
Zzgl. Versandkosten $45.00

General

Antigen Collagen, Type IV, alpha 3 (COL4a3) Antikörper
Epitop Middle Region
(8), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Schwein, Kaninchen, Ratte (Rattus)
(59), (28), (18), (3), (3), (2), (2), (1), (1), (1), (1), (1)
Wirt Kaninchen
(55), (4)
Klonalität
Polyklonal
Konjugat Dieser COL4a3 Antikörper ist unkonjugiert
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Western Blotting (WB)
(30), (22), (16), (13), (6), (4), (2), (1), (1), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-COL4a3 Antikörper

Target Details COL4a3 Anwendungsinformationen Handhabung Bilder
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN975163.
Sequenz DPGQPGPPGE QGPPGRCIEG PRGAQGLPGL NGLKGQQGRR GKTGPKGDPG
Homologie Cow: 93%, Dog: 91%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 91%, Pig: 93%, Rabbit: 85%, Rat: 91%
Produktmerkmale This is a rabbit polyclonal antibody against COL4A3. It was validated on Western Blot.
Reinigung Affinity Purified
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human COL4A3

Target Details COL4a3

Produktdetails anti-COL4a3 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung COL4A3 (COL4a3 Antibody Abstract)
Hintergrund Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. There are multiple alternate transcripts that appear to be unique to this human alpha 3 gene and alternate splicing is restricted to the six exons that encode this C-terminal domain. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Some exons of this gene are interspersed with exons of an uncharacterized gene which is on the opposite strand.
Alias Symbols: -
Protein Interaction Partner: VHL, UBC, SERPINE2, OSM, MFAP2, FBLN2, FN1, DCN, CD93, MMP9, APP, SAA1, MATN2, TGFBI, CAMK2B, USH2A, ANTXR2, COL4A3BP, HABP2,
Protein Size: 1637
Molekulargewicht 156 kDa
Gen-ID 1285
NCBI Accession NM_031362, NP_112730
UniProt E7ENN2
Forschungsgebiet Cancer, Angiogenesis, Extracellular Matrix
Pathways Sensory Perception of Sound, Positive Regulation of Endopeptidase Activity

Anwendungsinformationen

Produktdetails anti-COL4a3 Antikörper Target Details COL4a3 Handhabung Bilder zurück nach oben
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 1637 AA

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-COL4a3 Antikörper Target Details COL4a3 Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Bilder

Produktdetails anti-COL4a3 Antikörper Target Details COL4a3 Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Collagen, Type IV, alpha 3 (COL4a3) (Middle Region) antibody (ABIN2788301) WB Suggested Anti-COL4A3 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positiv...