Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Wählen Sie die Spezies und Applikation aus
anti-Human CHM Antikörper:
anti-Rat (Rattus) CHM Antikörper:
anti-Mouse (Murine) CHM Antikörper:
Sie gelangen zu unserer vorgefilterten Suche.
Horse (Equine) Polyclonal CHM Primary Antibody für WB - ABIN2792245
Ishiguro, Yamamoto, Fujita, Akasu, Kobayashi, Moriya: Effect of a clinical pathway after laparoscopic surgery for colorectal cancer. in Hepato-gastroenterology 2008
Show all 2 Pubmed References
Human Polyclonal CHM Primary Antibody für WB - ABIN1881197
Renner, Fiebig, Cropp, Weber, Kellner: Progression of retinal pigment epithelial alterations during long-term follow-up in female carriers of choroideremia and report of a novel CHM mutation. in Archives of ophthalmology 2009
In Choroideremia(Y42X/y) fibroblasts, there was a recovery of prenylation activity following treatment with either PTC124 (42 +/- 5%) or PTC-414 (36 +/- 11%), although an increase in REP1 protein was not detected in these cells, in contrast to the zebrafish model.
The degenerative phenotype resulting from a null mutation in the zebrafish gene indicates that hair cells and retinal cells require Rab escort protein 1 for survival.
The results of this study propose that in chm(-/-) zebrafish, maternally derived rep allows initial successful development of the embryo, but its gradual loss leads to multisystem disease and invariably to lethality.
Retinal dystrophy (zeige MERTK Antikörper) and SDD were detected in our female CHM carriers, and fundus patterns
Overexpression of REP1 in BEAS-2B cells enhanced cell growth and anchorage-independent colony formation with little increase in EGFR (zeige EGFR Antikörper) level and STAT3 (zeige STAT3 Antikörper) activation.
we demonstrated that REP1 blocked the nuclear trans-localization of FOXO3 through physically interacting with FOXO3, thereby suppressing FOXO3-mediated apoptosis. Importantly, the inhibition of REP1 combined with 5-FU treatment could lead to significant retarded tumor growth in a xenograft tumor model of human cancer cells
Our results showed CNV within the Rep-1 gene could be an important contributor in Chinese Choroideremia patients.
We describe the causative mutations in a large cohort of patients who also were examined clinically and explore potential genotype-phenotype correlations. By so doing, we further aimed to make inferences regarding the importance of particular regions of the CHM gene with respect to mutagenesis and to infer the importance of particular regions of the REP1 protein essential for normal function.
Six previously reported and five novel CHM mutations were detected in 11 Australian families clinically diagnosed with choroideremia.
The family segregated a REP1 mutation, suggesting choroideremia (CHM).
We report a novel CHM mutation, c.1475_1476insCA, identified by whole-exome sequencing in a family with X-linked CHM initially diagnosed as retinitis pigmentosa.
Sanger sequencing confirmed the mutations in CHM, including four novel (c.558_559delTT, c.964G>T, c.966delA, c.1166+2T>G) and two known (c.7031G>A and c.1584_1587delTGTT) mutations.
data demonstrate that SFPQ (zeige SFPQ Antikörper) orchestrates spatial gene expression of a newly identified RNA regulon essential for axonal viability.
These results are compatible with the idea that SFPQ (zeige SFPQ Antikörper), plays an important role regulating proliferation and migration during the development of the cerebral cortex.
these results show that PSF (zeige IL-3 Antikörper) can repress the transcriptional activation of VEGF (zeige VEGFA Antikörper) stimulated by IGF-1 (zeige IGF1 Antikörper) via recruitment of the Hakai (zeige CBLL1 Antikörper) complex
Quantitative proteomics reveals dynamic interaction of JNK (zeige MAPK8 Antikörper) with RNA transport granule proteins Sfpq (zeige SFPQ Antikörper) and Nono (zeige NONO Antikörper) during neuronal differentiation
Loss of the Chm/Rep1 gene causes premature accumulation of features of aging in the retinal pigment epithelium.
A protein complex was identified containing PSPC1 (zeige PSPC1 Antikörper), PSF (zeige IL-3 Antikörper) and LMX1B (zeige LMX1B Antikörper), suggesting the existence of this complex in mesodiencephalic dopaminergic neurons.
PSF (zeige IL-3 Antikörper) contributes to the stability of a subset of histone genes and that loss of H2AE (zeige HIST1H2AJ Antikörper) expression in the PSF (zeige IL-3 Antikörper)-deficient thymocytes uniquely contributes to an increase in thymic apoptosis.
analysis indicates PSF (zeige IL-3 Antikörper) within the PER complex recruits SIN3A (zeige SIN3A Antikörper), a scaffold for assembly of transcriptional inhibitory complexes, and the PER complex thereby rhythmically delivers histone deacetylases to the Per1 (zeige PER1 Antikörper) promoter, which repress Per1 (zeige PER1 Antikörper) transcription
Basal and cyclic AMP (zeige TMPRSS5 Antikörper)-induced Rbp4 (zeige RBP4 Antikörper) transcription is regulated by a multiprotein complex that is similar to ones that modulate expression of genes of steroid hormone biosynthesis.
identified as a protein kinase (zeige CDK7 Antikörper) Calpha (zeige PRKACA Antikörper)-binding protein in the cell nucleus
This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia\; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternative splicing results in multiple transcript variants encoding different isoforms.
Rab escort protein 1
, rab proteins geranylgeranyltransferase component A 2
, choroideremia (Rab escort protein 1)
, choroideremia protein
, rab proteins geranylgeranyltransferase component A 1
, choroideraemia protein homolog
, choroideremia protein homolog
, rab escort protein 1
, DNA-binding p52/p100 complex, 100 kDa subunit
, PTB-associated splicing factor
, PTB-associated-splicing factor
, polypyrimidine tract-binding protein-associated-splicing factor
, splicing factor, proline- and glutamine-rich