WASL Proteine (WASL)

Bezeichnung:
Wiskott-Aldrich Syndrome-Like Proteine (WASL)
Auf www.antikoerper-online.de finden Sie aktuell 0 Wiskott-Aldrich Syndrome-Like (WASL) Proteine von unterschiedlichen Herstellern. Insgesamt sind aktuell 0 WASL Produkte verfügbar.
Synonyme:
2900021I12Rik, 3110031I02Rik, IMD2, N-WASP, NWASP, SCNX, THC, THC1, TRS4, U42471, WASL, Wasp, zgc:55478, zgc:77237
alle Proteine anzeigen Gen GeneID UniProt
Human WASL WASL 7454 P42768
Ratte WASL WASL 317371  
Maus WASL WASL 22376 P70315

Weitere Synonyme anzeigen

Weitere Proteine zu WASL Interaktionspartnern

Human Wiskott-Aldrich Syndrome-Like (WASL) Interaktionspartner

  1. Results suggest that local invasiveness of ameloblastoma is dependent upon the migratory potential of its tumour cells as defined by their distribution of cortactin, N-WASP and WIP in correlation with F-actin cytoskeletal dynamics.

  2. A Treg-specific role for WASP is required for prevention of Th2 effector cell differentiation and allergic sensitization to dietary antigens.

  3. WASP and SCAR drive pseudopod formation and are conserved in actin-filled pseudopod-based motility.

  4. Authors show that knock-down of WASp or expression of Y102F mutant of WASp decreases colony formation and in vivo tumor growth. Results show that WASp is a novel substrate of ALK and has a critical role in regulating invasiveness and oncogenesis of ALCL.

  5. this study describes an Iranian boy with Wiskott-Aldrich syndrome with a novel WASP mutation

  6. The inducible recruitment of WASp to the TCR-CD3 (zeige CD3 Proteine) complex is partially dependent of tyrosine phosphorylation of Cd3e (zeige CD3E Proteine).

  7. This suggests that TOCA1 binding to Cdc42 is an early step in the Cdc42-dependent pathways that govern actin dynamics, and the differential binding affinities of the effectors facilitate a handover from TOCA1 to N-WASP, which can then drive recruitment of the actin-modifying machinery.

  8. the Cdc42 (zeige CDC42 Proteine)/Nwasp/stress fibers/YAP (zeige YAP1 Proteine) signal pathway may potentially play an important role in regulating podocyte apoptosis. Maintaining necessary Cdc42 (zeige CDC42 Proteine) would be one potent way to prevent proteinuria kidney diseases.

  9. Low GAS7C increases cancer cell motility by promoting N-WASP/FAK (zeige PTK2 Proteine)/F-actin cytoskeleton dynamics. It also enhances beta-catenin (zeige CTNNB1 Proteine) stability via hnRNP U (zeige HNRNPU Proteine)/beta-TrCP (zeige BTRC Proteine) complex formation.

  10. retrospectively investigated the outcome of hematopoietic stem cell transplantation in a cohort of 24 patients with the X-linked thrombocytopenia phenotype and mutations in the WAS gene

Mouse (Murine) Wiskott-Aldrich Syndrome-Like (WASL) Interaktionspartner

  1. DOCK8 and WASp are in the same signaling pathway that links T-cell receptors (TCRs) to the actin cytoskeleton in TCR-driven actin assembly.

  2. the dendritic cell actin cytoskeleton organized into recognizable synaptic structures, formed Wiskott-Aldrich syndrome protein-dependent podosomes within this area.

  3. N-WASP expression in B lymphocytes is required for the development of autoimmunity of WAS (Wiskott-Aldrich syndrome) and may represent a novel therapeutic target in WAS.

  4. Data (including data from studies in knockout mice) suggest that Cnr1 (cannabinoid receptor 1 (zeige CNR1 Proteine)) activation impacts actin cytoskeleton polymerization/stability via Wasl in growth cones of developing neurons and in synaptic spines of mature neurons.

  5. Platelet actin nodule formation is dependent on WASp and the ARP2 (zeige AICDA Proteine)/3 complex. WASp(-/-) mouse blood displays impaired platelet aggregate formation at arteriolar shear rates.

  6. Our data suggests that the N-WASP-Arp2/3 actin polymerization machinery generates branched-actin arrays at an advanced stage of blood-testis barrier remodeling.

  7. Findings suggest that Wiskott-Aldrich syndrome protein (WASp) plays a crucial role in B10 cell development and that WASp-deficient B10 cells may contribute to autoimmunity in Wiskott-Aldrich syndrome.

  8. N-terminus of Cas (zeige CTNND1 Proteine) associates with the FAK (zeige PTK2 Proteine)-N-WASP complex at the protrusive edge of the cell and that the C-terminus of Cas (zeige CTNND1 Proteine) associates with the immobilized integrin-SFK cluster.

  9. These results strongly suggest that the association between the WASP N-terminal domain and Btk plays an important role in the TLR2-signaling pathway in macrophages.

  10. Toca-1 (zeige FNBP1L Proteine)(knockdown) cells have defects in formation of myotubes probably due to reduced activity of actin cytoskeleton regulators such as N-WASP.

Cow (Bovine) Wiskott-Aldrich Syndrome-Like (WASL) Interaktionspartner

  1. N-WASP WWCA domains can processively attach to growing barbed-end bundles and increase their diffusion-limited elongation rate.

WASL Protein Überblick

Protein Überblick

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.

Alternative names and synonyms associated with WASL

  • Wiskott-Aldrich syndrome-like b (waslb)
  • Wiskott-Aldrich syndrome-like (wasl)
  • Wiskott-Aldrich syndrome-like (WASL)
  • Wiskott-Aldrich syndrome (WAS)
  • Wiskott-Aldrich syndrome (Was)
  • Wiskott-Aldrich syndrome homolog (human) (Was)
  • Wiskott-Aldrich syndrome-like (Wasl)
  • Wiskott-Aldrich syndrome-like (human) (Wasl)
  • 2900021I12Rik Protein
  • 3110031I02Rik Protein
  • IMD2 Protein
  • N-WASP Protein
  • NWASP Protein
  • SCNX Protein
  • THC Protein
  • THC1 Protein
  • TRS4 Protein
  • U42471 Protein
  • WASL Protein
  • Wasp Protein
  • zgc:55478 Protein
  • zgc:77237 Protein

Bezeichner auf Proteinebene für WASL

Wiskott-Aldrich syndrome-like , Wiskott-Aldrich syndrome, like , neural Wiskott-Aldrich syndrome protein , Wiskott-Aldrich syndrome gene-like protein , eczema-thrombocytopenia , thrombocytopenia 1 (X-linked) , wiskott-Aldrich syndrome protein , Wiskott-Aldrich syndrome homolog , wiskott-Aldrich syndrome protein homolog , N-WASP

GENE ID SPEZIES
394034 Danio rerio
407864 Xenopus (Silurana) tropicalis
417750 Gallus gallus
463688 Pan troglodytes
475213 Canis lupus familiaris
696556 Macaca mulatta
100171409 Pongo abelii
7454 Homo sapiens
317371 Rattus norvegicus
22376 Mus musculus
8976 Homo sapiens
682507 Rattus norvegicus
281577 Bos taurus
73178 Mus musculus
Haben Sie etwas anderes gesucht?