VEGFR2 Proteine (KDR)

Bezeichnung:
Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) Proteine (KDR)
Auf www.antikoerper-online.de finden Sie aktuell 66 Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) Proteine von 18 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen VEGFR2 Antikörper (750) und VEGFR2 Kits (93) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 934 VEGFR2 Produkte verfügbar.
Synonyme:
6130401C07, CD309, fk52c05, flk, flk-1, FLK/KDR, flk1, flk1b, kdr, kdra, kdrb, Krd-1, Ly73, si:busm1-205d10.1, si:ch211-254j6.1, si:ch211-278f21.4, sVEGFR-2, VEGFR, Vegfr-2, vegfr2, vegfr4, vegr2, wu:fc31a09, wu:fk52c05
alle Proteine anzeigen Gen GeneID UniProt
KDR 16542  
KDR 25589 O08775
KDR 3791 P35968

Weitere Synonyme anzeigen

VEGFR2 Proteine (KDR) nach Spezies

Wählen Sie die gewünschte Spezies

Am meisten referenzierte VEGFR2 Proteine

  1. Human VEGFR2 Protein expressed in HEK-293 - ABIN2666871 : Albuquerque, Hayashi, Cho, Kleinman, Dridi, Takeda, Baffi, Yamada, Kaneko, Green, Chappell, Wilting, Weich, Yamagami, Amano, Mizuki, Alexander, Peterson, Brekken, Hirashima, Capoor, Usui, Ambati et al.: Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. ... in Nature medicine 2009 (PubMed)
    Zeige alle 7 Referenzen für 2666871

  2. Mouse (Murine) VEGFR2 Protein expressed in CHO Cells - ABIN2666873 : DiSalvo, Bayne, Conn, Kwok, Trivedi, Soderman, Palisi, Sullivan, Thomas: Purification and characterization of a naturally occurring vascular endothelial growth factor.placenta growth factor heterodimer. in The Journal of biological chemistry 1995 (PubMed)
    Zeige alle 7 Referenzen für 2666873

  3. Mouse (Murine) VEGFR2 Protein expressed in Human Cells - ABIN2008496 : McTigue, Wickersham, Pinko, Showalter, Parast, Tempczyk-Russell, Gehring, Mroczkowski, Kan, Villafranca, Appelt: Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis. in Structure (London, England : 1993) 1999 (PubMed)
    Zeige alle 4 Referenzen für 2008496

  4. Mouse (Murine) VEGFR2 Protein expressed in Human Cells - ABIN2008494 : Terman, Dougher-Vermazen, Carrion, Dimitrov, Armellino, Gospodarowicz, Böhlen: Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. in Biochemical and biophysical research communications 1992 (PubMed)
    Zeige alle 4 Referenzen für 2008494

  5. Human VEGFR2 Protein expressed in Baculovirus infected Insect Cells - ABIN2001898 : Patterson, Perrella, Hsieh, Yoshizumi, Lee, Haber: Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor. in The Journal of biological chemistry 1995 (PubMed)
    Zeige alle 4 Referenzen für 2001898

  6. Rat (Rattus) VEGFR2 Protein expressed in Human Cells - ABIN2009182 : Holmqvist, Cross, Rolny, Hägerkvist, Rahimi, Matsumoto, Claesson-Welsh, Welsh: The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration. in The Journal of biological chemistry 2004 (PubMed)
    Zeige alle 4 Referenzen für 2009182

  7. Human VEGFR2 Protein expressed in Insect Cells - ABIN809790 : Hiley, Chard, Gangeswaran, Tysome, Briat, Lemoine, Wang: Vascular endothelial growth factor A promotes vaccinia virus entry into host cells via activation of the Akt pathway. in Journal of virology 2013 (PubMed)

Weitere Proteine zu VEGFR2 Interaktionspartnern

Rainbow Trout (Oncorhynchus mykiss) Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) Interaktionspartner

  1. These results indicate that VEGF-C (zeige VEGFC Proteine)-induced MSC (zeige MSC Proteine) osteogenesis is mediated through VEGFR2 and VEGFR3 (zeige FLT4 Proteine), and followed the activation of the ERK (zeige MAPK1 Proteine)/RUNX2 (zeige RUNX2 Proteine) signaling pathway.

Mouse (Murine) Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) Interaktionspartner

  1. Endoglin (zeige ENG Proteine) prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling

  2. CLEC14A (zeige CLEC14A Proteine) acts in vascular homeostasis by fine-tuning VEGFR-2 and VEGFR-3 (zeige FLT4 Proteine) signaling in endothelial cells

  3. The elevated soluble VEGFR-2 that was found in the aortas of apoE (zeige APOE Proteine)(-/-) mice with atherosclerosis binds to and diminishes the activity of VEGF-C (zeige VEGFC Proteine).

  4. Data show that Leishmania major infection initiates enhanced vascular endothelial growth factor-A (zeige VEGFA Proteine)/VEGFR-2 signaling and suggest that VEGFR-2-dependent lymphangiogenesis is a mechanism that restricts tissue inflammation in leishmaniasis.

  5. VEGFR3 (zeige FLT4 Proteine) limits VEGFR2 expression and VEGF (zeige VEGFA Proteine)/VEGFR2 pathway activity in quiescent and angiogenic blood vascular endothelial cells, thereby preventing excessive vascular permeability.

  6. fetal mouse lung mesenchymal cells express Vegfr2 and respond to VEGF-A (zeige VEGFA Proteine) stimulation.

  7. Deletion of microRNA miR (zeige MLXIP Proteine)-150 increased the retinal pathological angiogenesis in high-fat-diet (HFD) induced type 2 diabetic mice, which was in part through vascular endothelial growth factor receptor 2 (VEGFR2).

  8. findings demonstrated that a multi-component Chinese medicine DHI effectively increased blood flow recovery after tissue ischemia in diabetic mice by promoting angiogenesis and improving glucose tolerance through a concomitant activation of VEGF-A (zeige VEGFA Proteine)/VEGFR-2 and PPARdelta (zeige PPARD Proteine) signaling pathways

  9. Intronic Flk1 genetic enhancer element directs arterial-specific expression via RBPJ (zeige RBPJ Proteine)-mediated venous repression.

  10. Endothelial SCUBE2 may be a novel coreceptor for VEGFR2 and potentiate VEGF-induced signaling in adult angiogenesis.

Human Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) Interaktionspartner

  1. The results suggest that Necl-4 (zeige CADM4 Proteine) enhances VEGF (zeige VEGFA Proteine)-induced activation of PLCgamma-c-Raf (zeige RAF1 Proteine)-MEK (zeige MAP2K1 Proteine)-ERK (zeige EPHB2 Proteine) pathway without affecting the phosphorylation and internalization of VEGFR2.

  2. circRNA-MYLK (zeige MYLK Proteine) might function as competing endogenous RNA for miR (zeige MLXIP Proteine)-29a, which could contribute to empithelial-mesenchymal transformation and the development of bladder cancer by activating VEGFA (zeige VEGFA Proteine)/VEGFR2 and downstream Ras/ERK (zeige EPHB2 Proteine) signaling pathway.

  3. VEGFR2 is consistently expressed in small artery myocytes of older people and may mediate effects of VEGF on brain vascular aging.

  4. Chromatin-modifying agents converted hADFCs to OCT4+ and VEGFR-2+ capillary tube-forming cells in a 2D matrix in VEGF-dependent manner

  5. This study demonstrated that patient with schizophrenia Decreased VEGFR2 expression in prefrontal cortex.

  6. Papillary renal cell carcinoma (zeige MOK Proteine) patients with high VEGFR2 expression exhibited improved 10-year recurrence-free survival and cancer-specific survival.

  7. Letter: VEGFA (zeige VEGFA Proteine) and VEGFR2 SNPs were associated with susceptibility to Paget's disease of bone in Spanish patients.

  8. VEGFR2 expression by glioblastoma cells supports cell cycle progression and prevents cellular senescence

  9. PDGFAA in tumor drainage and HER2 (zeige ERBB2 Proteine) in peripheral vein blood may have roles in synchronous liver metastasis of colorectal cancer

  10. The changes in the ratios of mRNA levels and the respective proteins (HIF-1alpha (zeige HIF1A Proteine), HIF-2, NF-kB, VEGF (zeige VEGFA Proteine), VEGFR2, and carboanhydrase IX) may contribute to kidney-cancer metastasis.

Pig (Porcine) Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) Interaktionspartner

  1. Here we demonstrate that VEGF (zeige VEGFA Proteine)-165 mediates MSC (zeige MSC Proteine) differentiation into ECs via VEGFR-2-dependent induction of Sox18 (zeige SOX18 Proteine), which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype

  2. NOS stimulation via PI3K, calpain proteases, and SIRT1 (zeige SIRT1 Proteine)-dependent deacetylation downstream from VEGFR2 activation contributes to these vasodilator responses.

  3. we analyzed the expression and cellular distribution of Flt-1(VEGFR-1 (zeige FLT1 Proteine)) and Flk-1 (KDR/VEGFR-2)in newborn piglet brain

  4. expression of FLK1, CD146 (zeige MCAM Proteine) and microvessel density of angiogenesis at the first week of reperfused acute myocardial infarction.

  5. VEGF (zeige VEGFA Proteine) supplementation at the late embryonic developmental stage might improve the developmental potential of both IVF (zeige SCN5A Proteine) and somatic nuclear transfer preimplantation porcine embryos through its receptors.

  6. The VEGFR2 mRNA was only upregulated in early glomerulogenesis, suggesting that VEGFR2 is important for the vascular growth.

  7. increased placental expression of the VEGF receptor (zeige FLT1 Proteine) system is associated with increased placental vascular density observed with the advancement of gestation in the pig

  8. VEGF ligand-receptor system may play an important role in the development and maintenance of the corpus luteum in pigs.

  9. VEGF (zeige VEGFA Proteine)/Flk-1/Flt-1 (zeige FLT1 Proteine) system is activated during myocardial ischemia reperfusion injury.

  10. Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (zeige VEGFA Proteine), pro-MMP-9 (zeige MMP9 Proteine), MMP-2 (zeige MMP2 Proteine), VEGFR-1 (zeige FLT1 Proteine), VEGFR-2, and TIMP-1 (zeige TIMP1 Proteine), which may contribute to the development of venous stenosis.

Cow (Bovine) Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) Interaktionspartner

  1. data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.

  2. endothelial cells exposed to TGF-beta1 (zeige TGFB1 Proteine) lose both tip and stalk cell identity, possibly mediated by loss of VEGFR2 signaling.

  3. These results suggest that non-dominant follicles maintain a greater concentration of the mRNA expression of both membrane and soluble VEGF receptors; but follicular dominance is related to a reduction in the mRNA expression of sVEGFR1 and sVEGFR2.

  4. Data suggest that galectin-1 (zeige LGALS1 Proteine) and VEGFR-2 are expressed at mid-luteal stages in luteal cells of corpus luteum; galectin-1 (zeige LGALS1 Proteine) binds directly to asparagine-linked glycans (N-glycans) on VEGFR-2 in luteal cells.

  5. MMP-1 (zeige MMP1 Proteine) promotes VEGFR2 expression and proliferation of endothelial cells through stimulation of PAR-1 (zeige F2R Proteine) and activation of NF-kappaB (zeige NFKB1 Proteine)

  6. Vascular endothelial growth factor receptor-2 activates ADP-ribosylation factor 1 (zeige ARF1 Proteine) to promote endothelial nitric-oxide synthase (zeige NOS3 Proteine) activation and nitric oxide release from endothelial cells

  7. VEGFR2 mRNA expression was higher at the mid and late luteal stages than at the early I and early II luteal stages, and VEGFR2 protein was higher at the mid and late luteal stages than at estrus (P<0.05)

  8. Alterations in the expression of VEGF-A (zeige VEGFA Proteine) and bFGF (zeige FGF2 Proteine) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

  9. involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt (zeige AKT1 Proteine) and endothelial nitric-oxide synthase (eNOS (zeige NOS3 Proteine))

  10. Placenta growth factor (zeige PGF Proteine) expression is regulated by both VEGF (zeige VEGFA Proteine) and hyperglycaemia via VEGFR-2.

Rabbit Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) Interaktionspartner

  1. Antenatal intratracheal VEGF (zeige VEGFA Proteine) administration was associated with an increase in Flk-1 immunoreactivity.

Zebrafish Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) Interaktionspartner

  1. Intronic Flk1 genetic enhancer element directs arterial-specific expression via RBPJ (zeige RBPJ Proteine)-mediated venous repression.

  2. Ca(2 (zeige CA2 Proteine)+) oscillations depended upon VEGF receptor-2 (Vegfr2) and Vegfr3 (zeige FLT4 Proteine) in endothelial cells budding from the dorsal aorta (DA) and posterior cardinal (zeige CARD8 Proteine) vein, respectively.

  3. Methylglyoxal acts on smaller blood vessels in zebrafish via the VEGF receptor (zeige FLT1 Proteine) signaling cascade, thereby describing a new mechanism that can explain vascular complications under hyperglycemia and elevated MG concentrations.

  4. methylation of Lys (zeige LYZ Proteine)(1041) promotes the activation of VEGFR-2 and that similar posttranslational modification could also regulate the activity of other receptor tyrosine kinases.

  5. Perturbation of the HSP70 (zeige HSPA1A Proteine)-HSP90 (zeige HSP90 Proteine) heat-shock protein axis stimulates degradation of endothelial VEGFR2.

  6. Data indicate that the increase in FLT1/sFLT1 (zeige FLT1 Proteine) protein levels upon miR-10 (zeige LILRB2 Proteine) knockdown inhibited the angiogenic behavior of endothelial cells largely by antagonizing vascular endothelial growth factor receptor 2 signaling: [miR10 (zeige LILRB2 Proteine)]

  7. Early Flk1 expression may be induced by cooperative interactions between Gata (zeige GATA4 Proteine), Tcf (zeige HNF4A Proteine)/Lef, Cdx (zeige CDX1 Proteine) and ER71/Etv2 (zeige ETV2 Proteine) under the control of Bmp, Wnt (zeige WNT2 Proteine) and Fgf signaling.

  8. Using 2 distinct pharmacologic VEGFR2 inhibitors the study shows that rap1b (zeige RAP1A Proteine) and VEGFR2 act additively to control angiogenesis in vivo.

  9. Data show that flk1 is not required for proper vasculogenesis and hematopoiesis in zebrafish embryos; however, the disruption of flk1 impairs the formation or function of vessels generated by sprouting angiogenesis

  10. flk1 is a direct target of FoxH1 (zeige FOXH1 Proteine); FoxH1 (zeige FOXH1 Proteine) is involved in vessel formation in zebrafish.

VEGFR2 (KDR) Protein Überblick

Protein Überblick

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.

Alternative names and synonyms associated with VEGFR2 (KDR)

  • vascular endothelial growth factor receptor 2 (vegfr-2)
  • kinase insert domain protein receptor (Kdr)
  • kinase insert domain receptor (Kdr)
  • kinase insert domain receptor (a type III receptor tyrosine kinase) (KDR)
  • kinase insert domain receptor (a type III receptor tyrosine kinase) (Kdr)
  • kinase insert domain receptor (a type III receptor tyrosine kinase) (kdr)
  • kinase insert domain receptor like (kdrl)
  • vascular endothelial growth factor receptor-2 (KDR)
  • 6130401C07 Protein
  • CD309 Protein
  • fk52c05 Protein
  • flk Protein
  • flk-1 Protein
  • FLK/KDR Protein
  • flk1 Protein
  • flk1b Protein
  • kdr Protein
  • kdra Protein
  • kdrb Protein
  • Krd-1 Protein
  • Ly73 Protein
  • si:busm1-205d10.1 Protein
  • si:ch211-254j6.1 Protein
  • si:ch211-278f21.4 Protein
  • sVEGFR-2 Protein
  • VEGFR Protein
  • Vegfr-2 Protein
  • vegfr2 Protein
  • vegfr4 Protein
  • vegr2 Protein
  • wu:fc31a09 Protein
  • wu:fk52c05 Protein

Bezeichner auf Proteinebene für KDR

vascular endothelial growth factor receptor 2 , VEGF receptor-2 , fetal liver kinase 1 , kinase NYK , protein-tyrosine kinase receptor flk-1 , soluble vascular endothelial growth factor receptor 2 , vascular endothelial growth factor receptor- 2 , vascular endothelial growth factor receptor-2 , vascular endothelial growth factor receptor-3 , FLK-1 , FLK1 kinase insert domain receptor (VEGF receptor 2) , FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2) , kinase insert domain protein receptor , fetal liver kinase-1 , protein-tyrosine kinase receptor Flk-1 , soluble VEGFR2 , tyrosine kinase growth factor receptor , flk-1 type VEGF receptor , VEGFR2 , flk-1 receptor , protein-tyrosine kinase , tyrosine kinase receptor , VEGF receptor-2/Flk-1 , FLK-1b , VEGFR-2 homolog B , fetal liver kinase 1b , kinase insert domain receptor (a type III receptor tyrosine kinase), b , kinase insert domain receptor-B , protein-tyrosine kinase receptor flk-1b , vascular endothelial growth factor receptor 2 homolog B , VEGFR-4 , kinase insert domain receptor-A , kinase insert domain receptor-like , vascular endothelial growth factor receptor 4 , vascular endothelial growth factor receptor kdr-like , vascular endothelial growth factor receptor type 2

GENE ID SPEZIES
100136647 Oncorhynchus mykiss
16542 Mus musculus
25589 Rattus norvegicus
3791 Homo sapiens
397311 Sus scrofa
482154 Canis lupus familiaris
395323 Gallus gallus
407170 Bos taurus
100726761 Cavia porcellus
100008607 Oryctolagus cuniculus
554230 Danio rerio
796537 Danio rerio
443087 Ovis aries
Ausgewählte Anbieter für VEGFR2 Proteine (KDR)
Haben Sie etwas anderes gesucht?