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By immunohistochemistry, the localization of Neurotrophinss has been observed mainly in Purkinje cells; TrkA (zeige NTRK1 Proteine) and TrkB-receptors in cells and fibers of granular and molecular layers. TrkC (zeige NTRK3 Proteine) was faintly detected
BDNF (zeige BDNF Proteine)-TrkB influences the expression level of components of chemokine (zeige CCL1 Proteine) signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.
Light regulates the expression of the BDNF (zeige BDNF Proteine)/TrkB2 system in the adult zebrafish retina.
Study showed that complex relationships exist between BDNF (zeige BDNF Proteine)/TrkB gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence
Data suggest that high expression of TRKB (not TRKA (zeige NTRK1 Proteine) or TRKC (zeige NTRK3 Proteine)) in lung squamous cell carcinoma is correlated with vascular invasion, lymph node metastasis, advanced stage of tumor, and poor prognosis; overall survival of patients with TRKB-high expression is significantly shorter than those with TRKB-low expression; RNA interference against TRKB or BDNF (zeige BDNF Proteine) (TRKB agonist) inhibits cell proliferation of tumor cell line.
Among the adaptations observed following consumption of drugs of abuse or alcohol abuse, BDNF (zeige BDNF Proteine) levels are widely altered in both brain and periphery. Data suggest that BDNF (zeige BDNF Proteine)/TRKB signaling in neurons in specific areas of brain (hippocampus, nucleus accumbens) is altered in protracted withdrawal from drug/alcohol abuse. [REVIEW]
Data suggest that kinase domains of neurotrophin (zeige BDNF Proteine) receptor isoforms, TRKA (zeige NTRK1 Proteine), TRKB, and TRKC (zeige NTRK3 Proteine), exhibit a bulky phenylalanine gatekeeper, leading to a small and unattractive back pocket/binding site for antineoplastic kinase inhibitors. [REVIEW]
Pan-Trk (zeige NTRK1 Proteine) immunohistochemistry is a time-efficient and tissue-efficient screen for NTRK fusions, particularly in driver-negative advanced malignancies and potential cases of secretory carcinoma and congenital fibrosarcoma.
High TRKB expression is associated with Small Cell Lung Cancer.
Co-immunoprecipitation and biochemical fractionation data suggested that p75 (zeige CUX1 Proteine) TM stimulates TrkB phosphorylation at the cell membrane.
High NTRK2 expression is associated with astrocytomas.
overexpression of TrkB, but not of BDNF (zeige BDNF Proteine), is significantly associated with a poor survival outcome for TNBC patients.
In the current work, we provide a global analysis of the physiological consequences of TrkB receptor activation in vitro and discuss the dynamic consequences of TrkB activation in vivo. Finally, we propose a clinically-feasible option for increasing BDNF (zeige BDNF Proteine) expression in the hypothalamus to more readily utilize the oncolytic effects of BDNF (zeige BDNF Proteine).
ShcD (zeige SHC4 Proteine) binds to active Ret (zeige RET Proteine), TrkA (zeige NTRK1 Proteine), and TrkB neurotrophic factor (zeige NTF3 Proteine) receptors predominantly via its phosphotyrosine-binding (PTB (zeige PTBP1 Proteine)) domain.
BDNF (zeige BDNF Proteine) acts retrogradely on TrkB in climbing fibers , and facilitates elimination of climbing fibers synapses from Purkinje cells somata during the third postnatal week.
The three receptor sets considered (mAChR (zeige CHRM3 Proteine), AR and TrkB receptors) intervene in modulating the conditions of the competition between nerve endings.
Signaling through postsynaptic trkB receptors is considered to be an essential part of a cellular mechanism for maintaining the contacts of some, but not all, synaptic contacts onto motoneurons
findings show that BDNF (zeige BDNF Proteine)-TrkB signaling, rather than Dopamine signaling, in the Ventral Tegmental Area -Nuc (zeige SREBF2 Proteine). Accumbens circuit is crucial for facilitating depressive-like depressive-like outcomes after Chronic Social Defeat Stress and they establish BDNF (zeige BDNF Proteine)-TrkB signaling as a pathologic mechanism during periods of chronic stress.
inhibition of Sig (zeige PICALM Proteine)-1 R prevented cocaine-induced TrkB activation in hippocampal neurons.
After spinal cord injury, astrocyte-specific TrkB knock-out mice showed reduced hyperpathic responses and improved motor coordination.
Results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the brain-derived neurotrophic factor (zeige BDNF Proteine) -ERK1/2-cAMP response element-binding protein pathway through tropomyosin receptor kinase (zeige NTRK1 Proteine) B activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits.
Data show that c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) participates in the migration of cortical neurons during cortical development by mediating TrkB receptor axonal anterograde transport.
findings reveal a spine-autonomous, autocrine signalling mechanism involving NMDAR (zeige GRIN1 Proteine)-CaMKII (zeige CAMK2G Proteine)-dependent BDNF (zeige BDNF Proteine) release from stimulated dendritic spines and subsequent TrkB activation on these same spines that is crucial for structural and functional plasticity
Following ethanol administration, phosphorylation of TrkB in the striatum was significantly reduced in wild-type mice.
These observations provided evidence that brain-derived naeurotrophic factor(BDNF (zeige BDNF Proteine)) and its receptor (BDNF (zeige BDNF Proteine) receptor) secreted by bovine sperm was important in regulation of insulin (zeige INS Proteine) and leptin (zeige LEP Proteine).
Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic autocrine pathwy involving bdnf (zeige BDNF Proteine)-Trk-B
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene.
neurotrophin receptor B xTrkB-alpha
, BDNF/NT-3 growth factors receptor
, neurotrophic tyrosine kinase, receptor, type 2
, BDNF/NT-3 growth factors receptor-like
, neurotrophic tyrosine kinase receptor type 2
, trkB tyrosine kinase
, tyrosine kinase receptor
, BDNF-tropomyosine receptor kinase B
, tropomyosin-related kinase B
, tyrosine kinase receptor B
, neural receptor protein-tyrosine kinase (trkB)
, trkB protein