anti-Human SHC3 Antikörper für Immunofluorescence

Recommended SHC3 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
SHC (Src Homology 2 Domain Containing) Transforming Protein 3 (SHC3) Antikörper
  • N-Shc
  • NSHC
  • RAI
  • SHCC
  • ShcC
  • Rai
  • SHC (Src homology 2 domain containing) transforming protein 3
  • src homology 2 domain-containing transforming protein C3
  • SHC3
  • Shc3
Epitop
AA 239-374
15
6
5
4
3
3
2
2
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
54
37
32
4
4
4
4
4
2
2
1
1
Wirt
Maus
51
5
Klonalität
Monoklonal
Konjugat
Dieser SHC3 Antikörper ist unkonjugiert
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
33
13
13
13
8
3
3
3
1
1
Optionen
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Bilder

Produktnummer ABIN968083
Preis und Verfügbarkeit auf Anfrage.
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
12.14905 ABIN968082 IF IP IHC WB Mouse IgG1 AA 239-374 Anmelden zum Anzeigen 23-ShcC 3
12.14905 ABIN5079622 ICC IF WB Rabbit IgG Anmelden zum Anzeigen Polyclonal
12.14905 ABIN5079623 ICC IF Rabbit IgG Anmelden zum Anzeigen Polyclonal

General

Antigen SHC (Src Homology 2 Domain Containing) Transforming Protein 3 (SHC3) Antikörper
Epitop AA 239-374
(15), (6), (5), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(54), (37), (32), (4), (4), (4), (4), (4), (2), (2), (1), (1)
Wirt Maus
(51), (5)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser SHC3 Antikörper ist unkonjugiert
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(33), (13), (13), (13), (8), (3), (3), (3), (1), (1)
Pubmed 3 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-SHC3 Antikörper

Target Details SHC3 Anwendungsinformationen Handhabung Referenzen für anti-SHC3 Antikörper (ABIN968083) Bilder
Kreuzreaktivität Ratte (Rattus), Human
Produktmerkmale 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Mouse ShcC aa. 239-374
Klon 23-ShcC
Isotyp IgG1

Target Details SHC3

Produktdetails anti-SHC3 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-SHC3 Antikörper (ABIN968083) Bilder zurück nach oben
Antigen
Andere Bezeichnung ShcC (SHC3 Antibody Abstract)
Hintergrund Mammalian ShcA is expressed as three proteins of 46 kDa, 52 kDa, and 66 kDa. Each protein contains a C-terminal SH2 domain, a central glycine/proline rich sequence, and an N-terminal phosphotyrosine-binding domain (PTB). All three Shc proteins become tyrosine phosphorylated by activated growth factor receptors and oncogene tyrosine kinases. Two additional murine genes with Shc homology have been identified and named ShcB and ShcC. The ShcC gene encodes a protein of 475 amino acids and mobility of 55 kDa. Additional immunoreactive proteins have been observed with apparent molecular weights of 69 kDa and 100 kDa. These could be due to extended 5' sequences in the ShcC gene. In contrast to widely distributed ShcA proteins, expression of ShcC is restricted to the nervous system and spleen.
Molekulargewicht 69 & 55 kDa
Pathways RTK Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung

Anwendungsinformationen

Produktdetails anti-SHC3 Antikörper Target Details SHC3 Handhabung Referenzen für anti-SHC3 Antikörper (ABIN968083) Bilder zurück nach oben
Kommentare

Related Products: ABIN968545, ABIN967389

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-SHC3 Antikörper Target Details SHC3 Anwendungsinformationen Referenzen für anti-SHC3 Antikörper (ABIN968083) Bilder zurück nach oben
Format Liquid
Konzentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store undiluted at -20° C.

Referenzen für anti-SHC3 Antikörper (ABIN968083)

Produktdetails anti-SHC3 Antikörper Target Details SHC3 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Tarr, Roncarati, Pelicci, Pelicci, DAdamio: "Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc." in: The Journal of biological chemistry, Vol. 277, Issue 19, pp. 16798-804, 2002

Conti, Sipione, Magrassi, Bonfanti, Rigamonti, Pettirossi, Peschanski, Haddad, Pelicci, Milanesi, Pelicci, Cattaneo: "Shc signaling in differentiating neural progenitor cells." in: Nature neuroscience, Vol. 4, Issue 6, pp. 579-86, 2001

OBryan, Songyang, Cantley, Der, Pawson: "A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 7, pp. 2729-34, 1996

Bilder

Produktdetails anti-SHC3 Antikörper Target Details SHC3 Anwendungsinformationen Handhabung Referenzen für anti-SHC3 Antikörper (ABIN968083) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 3 (SHC3) (AA 239-374) antibody (ABIN968083) Western blot analysis of ShcC on a rat cerebrum lysate. Lane 1: 1:5000, lane 2: 1:10,...
Immunofluorescence (IF) image for anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 3 (SHC3) (AA 239-374) antibody (ABIN968083) Immunofluorescence staining of PFSK-1 cells (Human neuroectodermal tumor line, ATCC C...
 image for anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 3 (SHC3) (AA 239-374) antibody (ABIN968083) anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 3 (SHC3) (AA 239-374) antibody (Image 3)
Western Blotting (WB) image for anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 3 (SHC3) (AA 239-374) antibody (ABIN968083) anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 3 (SHC3) (AA 239-374) antibody (Image 4)