anti-SHC1 (SHC1) Antikörper

Bezeichnung:
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 Antikörper (SHC1)
Auf www.antikoerper-online.de finden Sie aktuell 244 SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Antikörper von 26 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SHC1 Kits (14) und SHC1 Proteine (12) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 281 SHC1 Produkte verfügbar.
Synonyme:
p66, p66shc, Shc, SHC1, ShcA, si:dkey-246i14.4, wu:fc10h03

Meistgesuchte Reaktivitäten zu anti-SHC1 (SHC1) Antikörper

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anti-Human SHC1 Antikörper:

anti-Rat (Rattus) SHC1 Antikörper:

anti-Mouse (Murine) SHC1 Antikörper:

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Am meisten referenzierte anti-SHC1 Antikörper

  1. Chicken Monoclonal SHC1 Primary Antibody für IF, WB - ABIN968228 : Imokawa, Kobayasi, Miyagishi: Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptor. in The Journal of biological chemistry 2000 (PubMed)
    Zeige alle 5 Referenzen für 968228

  2. Human Polyclonal SHC1 Primary Antibody für IF, IHC (p) - ABIN197086 : Trampont, Zhang, Ravichandran: ShcA mediates the dominant pathway to extracellular signal-regulated kinase activation during early thymic development. in Molecular and cellular biology 2006 (PubMed)
    Zeige alle 3 Referenzen für 197086

  3. Human Polyclonal SHC1 Primary Antibody für IF, WB - ABIN197084 : Patrussi, Savino, Pellegrini, Paccani, Migliaccio, Plyte, Lanfrancone, Pelicci, Baldari: Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival. in Oncogene 2005 (PubMed)
    Zeige alle 3 Referenzen für 197084

  4. Human Polyclonal SHC1 Primary Antibody für IF, IHC (p) - ABIN197590 : van der Geer, Wiley, Gish, Pawson: The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions. in Current biology : CB 1997 (PubMed)
    Zeige alle 3 Referenzen für 197590

  5. Cow (Bovine) Polyclonal SHC1 Primary Antibody für WB - ABIN2784202 : George, Schuller, Harris, Ladbury: A phosphorylation-dependent gating mechanism controls the SH2 domain interactions of the Shc adaptor protein. in Journal of molecular biology 2008 (PubMed)

  6. Human Monoclonal SHC1 Primary Antibody für IF, IHC - ABIN2453637 : Bhat, Baba, Adams, Khanday: Role of SNTA1 in Rac1 activation, modulation of ROS generation, and migratory potential of human breast cancer cells. in British journal of cancer 2014 (PubMed)

Weitere Antikörper gegen SHC1 Interaktionspartner

Human SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Interaktionspartner

  1. NIC (zeige NCSTN Antikörper) exacerbated AZA-dependent injury via augmenting p66shc transcription. While RES suppressed NIC (zeige NCSTN Antikörper)+AZA-mediated injury, -surprisingly-it further enhanced activity of the p66shc promoter. RES protected cells via the cytoplasmic p66shc/Nrf2 (zeige GABPA Antikörper)/heme oxygenase-1 (HO-1 (zeige HMOX1 Antikörper)) axis

  2. The results show that the interaction between STS-1 (zeige STS1 Antikörper) and ShcA is regulated in response to EGF receptor (zeige EGFR Antikörper) activation.

  3. Nox4 (zeige NOX4 Antikörper)-derived H2O2 in part activates Nox2 (zeige CYBB Antikörper) to increase mitochondrial ROS (zeige ROS1 Antikörper) via pSer36-p66Shc, thereby enhancing VEGFR2 (zeige KDR Antikörper) signaling and angiogenesis in endothelial cells.

  4. Taken together, these data argue for a complex mechanism of PKC-beta-dependent regulation of SH (zeige POLD3 Antikörper)CA (p66) activation invol (zeige SIGLEC1 Antikörper)ving Ser(139) and a motif surroun (zeige SIGLEC1 Antikörper)ding Ser(213).

  5. Data identify, for the first time, a novel non-canonical dynamic mode of interaction between Met and the p66 (zeige POLD3 Antikörper) protein isoform of Shc and its effects on rewiring binding effector complexes according to the activation state of the receptor.

  6. regulates the alternative splicing of XAF1 (zeige XAF1 Antikörper) in extracellular matrix-detachment induced autophagy to coordinate with the anoikic cell death

  7. The silence of p66(Shc) in HCT8 cells reduced the proliferation and accelerated the apoptosis, in addition, the expression of pro-apoptotic proteins caspase-3 (zeige CASP3 Antikörper), caspase-9 (zeige CASP9 Antikörper), Bax (zeige BAX Antikörper) was enhanced and the expression of anti-apoptotic protein Bcl-2 (zeige BCL2 Antikörper) was declined.

  8. In mice and humans, reduced p66Shc levels protect from obesity, but not from ectopic fat accumulation, glucose intolerance and insulin (zeige INS Antikörper) resistance.

  9. Data suggest SHC1 (SH2 domain protein C1) expression down-regulates epithelial-mesenchymal transition by repressing TGFB (zeige TGFB1 Antikörper)-induced SMAD2 (zeige SMAD2 Antikörper)/3 activation through differential partitioning of receptors at cell surface of mammocytes/keratinocytes.

  10. p66shc expression in coronary heart disease patients was significantly higher compared with the control group

Zebrafish SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Interaktionspartner

  1. Data show that adaptor protein Shc is required for angiogenesis in zebrafish (accession number LOC563639), mice, and human vascular endothelial cell-culture models.

Xenopus laevis SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Interaktionspartner

  1. ShcA is required for Wnt-5a (zeige WNT5A Antikörper)/Ror2 (zeige ROR2 Antikörper) mediated upregulation of xPAPC (zeige PCDH8 Antikörper), which demonstrates the functional relevance of this interaction.

Cow (Bovine) SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Interaktionspartner

  1. Studied p66Shc levels, redox state, and developmental potential in early bovine embryos. p66Shc content was increased by either high (20%) O(2) culture or H(2)O(2) treatment, and significantly dec'd by antioxidant polyethylene glycol-conjugated catalase (zeige CAT Antikörper).

  2. p66shc, but not p53 (zeige TP53 Antikörper), is significantly more abundant in an embryo population that exhibits higher frequencies of embryo arrest.

  3. p66Shc is involved in the regulation of embryo development specifically in mediating early cleavage arrest and facilitating development to the blastocyst stage for in vitro produced bovine embryos

  4. These results support a model in which Shc orchestrates signals from cell-cell and cell-matrix adhesions to elicit flow-induced inflammatory signaling.

Mouse (Murine) SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Interaktionspartner

  1. Hyperglycemia and elevated free fatty acids in the diabetic milieu recruit p66Shc to upregulate endothelial miR (zeige MLXIP Antikörper)-34a via an oxidant-sensitive mechanism, which leads to endothelial dysfunction by targeting Sirt1 (zeige SIRT1 Antikörper).

  2. p66SHC-mediated oxidative stress and telomere shortening synergize in some tissues (including testes) to accelerate aging.

  3. Taken together, these data argue for a complex mechanism of PKCbeta-dependent regulation of p66 (zeige POLD3 Antikörper) activation involving Ser (zeige SIGLEC1 Antikörper)(139) and a motif surrounding Ser (zeige SIGLEC1 Antikörper)(213).

  4. JNK1 (zeige MAPK8 Antikörper)/2-dependent regulation of p66ShcS36 phosphorylation, is reported.

  5. Data show that the major mitochondrial partner of Shc adaptor protein p46Shc is the lipid oxidation enzyme 3-ketoacylCoA thiolase (zeige HADHB Antikörper) ACAA2 (zeige ACAA2 Antikörper), to which p46Shc binds directly and with a strong affinity.

  6. In mice and humans, reduced p66Shc levels protect from obesity, but not from ectopic fat accumulation, glucose intolerance and insulin (zeige INS Antikörper) resistance.

  7. p53 (zeige TP53 Antikörper)-dependent augmentation of p66(Shc) expression and function represents a key signalling response contributing to beta cell apoptosis under conditions of lipotoxicity

  8. Silencing of p66(Shc) restored insulin (zeige INS Antikörper) response via IRS-1 (zeige IRS1 Antikörper)/Akt (zeige AKT1 Antikörper)/eNOS (zeige NOS3 Antikörper) pathway. Its knockdown in endothelial cells from Ob/Ob mice lessened ROS (zeige ROS1 Antikörper) production, FFA oxidation, and dysregulation of redox-sensitive pathways.

  9. These data identify multiple modes by which ShcA can fine-tune the development of early thymocytes, including a previously unappreciated ShcA-c-Abl axis that regulates thymocyte proliferation.

  10. PKCbeta2 inhibition protects mice from gut (zeige GUSB Antikörper) ischemia-reperfusion injury by suppressing the adaptor p66(Shc)-mediated oxidative stress and subsequent apoptosis.

SHC1 Antigen-Profil

Beschreibung des Gens

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SHC1

  • SHC (Src homology 2 domain containing) transforming protein 1 (SHC1) Antikörper
  • Shc1p (SHC1) Antikörper
  • squalene--hopene cyclase (shc1) Antikörper
  • SHC (Src homology 2 domain containing) transforming protein 1 (LOC100229782) Antikörper
  • SHC (Src homology 2 domain containing) transforming protein 1 (Shc1) Antikörper
  • SHC (Src homology 2 domain containing) transforming protein 1 (shc1) Antikörper
  • src homology 2 domain-containing transforming protein C1 (Shc1) Antikörper
  • p66 Antikörper
  • p66shc Antikörper
  • Shc Antikörper
  • SHC1 Antikörper
  • ShcA Antikörper
  • si:dkey-246i14.4 Antikörper
  • wu:fc10h03 Antikörper

Bezeichner auf Proteinebene für SHC1

SHC (Src homology 2 domain containing) transforming protein 1 , Shc1p , Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH , squalene--hopene cyclase , SH2 domain protein C1 , SHC-transforming protein 1 , src homology 2 domain-containing-transforming protein C1 , SHC-transforming protein 1-like , SHC (Src homology 2 domain-containing) transforming protein 1 , SHC-transforming protein 3 , SHC-transforming protein A , src homology 2 domain-containing transforming protein C1 , p60Shc , src homology collagen , adaptor protein SHC

GENE ID SPEZIES
457351 Pan troglodytes
856832 Saccharomyces cerevisiae S288c
4234272 Frankia alni ACN14a
4944146 Saccharopolyspora erythraea NRRL 2338
100016090 Monodelphis domestica
100063053 Equus caballus
100173225 Pongo abelii
100390337 Callithrix jacchus
100480856 Ailuropoda melanoleuca
100540048 Meleagris gallopavo
100606068 Nomascus leucogenys
100229782 Taeniopygia guttata
6464 Homo sapiens
85385 Rattus norvegicus
323818 Danio rerio
399198 Xenopus laevis
395934 Gallus gallus
490439 Canis lupus familiaris
507196 Bos taurus
20416 Mus musculus
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