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The CnB 5I/5D variation was found to be significantly associated with CAD. The 5-base pair deletion results in increased serum calcineurin levels.
The mRNA expressions of PPP3CB (zeige PPP3CB Proteine) and MEF2C (zeige MEF2C Proteine) were significantly up-regulated, and CAMK1 (zeige CAMK1 Proteine) and PPP3R1 were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB (zeige PPP3CB Proteine), MEF2C (zeige MEF2C Proteine) and PLCE1 (zeige PLCE1 Proteine) compared to aortic valve disease patients
we report that exogenous CnB is taken up by cells in a time- and concentration-dependent manner via clathrin-dependent receptor-mediated internalization. Our findings further confirm that uptake is mediated by the TLR4 (zeige TLR4 Proteine)/MD2 (zeige LY96 Proteine) complex together with the co-receptor CD14 (zeige NDUFA2 Proteine)
CnB is a novel host-derived immunostimulatory factor, having a role as an agonist in monocytes, and specificity in TLR4 (zeige TLR4 Proteine) signaling through TRAF3 (zeige TRAF3 Proteine) and TRAF6 (zeige TRAF6 Proteine), in response to various agonists.
Data (including data from micro-dissected trophoblasts and trophoblastic BeWo cell line) suggest that microRNA-512-3p participates in placental function by targeting PPP3R1, encoding a regulatory subunit of calcineurin B.
Further evidence that specific variations in MAPT (zeige MAPT Proteine) (rs3785883) and PPP3R1 (rs1868402) are associated with accelerated progression of Alzheimer's disease
Expression level of PPP3R1 and GATA4 (zeige GATA4 Proteine), and NFATC4 (zeige NFATC4 Proteine) genes for transcription factors did not differ in studied subgroups of patients.
Pancreatic beta cells lacking Cnb1 fail to express genes revealed to be direct NFAT (zeige NFATC1 Proteine) targets required for replication, insulin (zeige INS Proteine) storage, and secretion.
These findings reveal a novel signaling pathway (CnB-CD11b (zeige ITGAM Proteine)-NF-kappaB (zeige NFKB1 Proteine)-TRAIL) regulating TRAIL expression and may help to understand the roles of the calcineurin B subunit in the regulation of innate immunity.
CnB M118K fails to enhance the activities of NF-AT and p53 induced by CnA in HeLa-s cells.
global deficiency of catalytic subunit Ppp3cb (zeige PPP3CB Proteine), and tissue-specific ablation of regulatory subunit Ppp3r1 from skeletal muscle, but not adipose tissue or liver, led to protection from high-fat-diet-induced obesity
data demonstrate that decreasing calcineurin activity in the amygdala increases anxiety-like behaviors and to some extent depression-like behaviors.
Macrophage Wnt (zeige WNT2 Proteine)-Calcineurin-Flt1 (zeige FLT1 Proteine) signaling regulates mouse wound angiogenesis and repair.
intact calcineurin/NFAT (zeige NFATC1 Proteine) signalling is critically required for p53 (zeige TP53 Proteine) and senescence-associated mechanisms that protect against skin squamous cancer development
Mechanistically, loss of Heart-specific CnB1 reduced expression of key Ca(2 (zeige CA2 Proteine)+)-handling genes that likely lead to arrhythmia and reduced contractility
Calcineurin B1 is essential for positive selection during thymocyte development.
gene expression of peroxisome proliferator-activated receptor gamma (zeige PPARG Proteine) coactivator 1alpha and peroxisome proliferator-activated receptor alpha (zeige PPARA Proteine) was reduced in the hearts of mice with cardiac-specific ablation of the Cn regulatory subunit.
interconnection exists between Notch 1 (zeige NOTCH1 Proteine) and Calcineurin-NFAT (zeige NFATC1 Proteine) pathways in keratinocyte growth/differentiation control
The calcineurin/Nfat (zeige NFATC1 Proteine) pathway controls the morphologic maturation of lungs prior to birth and regulates expression of genes involved in surfactant homeostasis that are critical for adaptation to air breathing.
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
, calcineurin subunit B type 1
, protein phospatase 3 regulatory subunit B alpha isoform type 1
, protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform
, protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)
, calcineurin B, type I (19kDa)
, protein phosphatase 2B regulatory subunit 1
, protein phosphatase 2B regulatory subunit B alpha
, protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)
, calcineurin B
, protein phosphatase 3 regulatory subunit B alpha
, protein phospatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
, protein phospatase 3, regulatory subunit B, alpha isoform,type 1
, protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
, PP2B beta 1