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NFAT is activated through calcineurin and interacts with NFsmall ka, CyrillicB after P. aeruginosa lung infection, and contributes to the host inflammatory response.
IKKepsilon (zeige IKBKE ELISA Kits) promotes NFATc1 phosphorylation and inhibits T cell responses, identifying IKKepsilon (zeige IKBKE ELISA Kits) as a crucial negative regulator of T cell activation and a potential target for immunotherapy.
Transplantation from GRIM19 (zeige NDUFA13 ELISA Kits)-overexpressing cells downregulated the expression of nuclear factor of activated T cells (NFATc1) but promoted the expression of regulator of calcineurin (RCAN)3 (zeige RCAN3 ELISA Kits) while downregulating NFAT-dependent cytokine gene expression.
These results suggest that the Keap1 (zeige KEAP1 ELISA Kits)/Nrf2 (zeige NFE2L2 ELISA Kits) axis plays a critical role in NFATc1 expression and osteoclastogenic progression.
Inhibition of calcineurin activity with FK506 or blockage of L-type calcium channels with nifedipine significantly suppressed NFATc1 mRNA expression and CTSK (zeige CTSK ELISA Kits) protein expression.
astrocytes were strongly associated with proteolysis of the protein phosphatase calcineurin (CN) and the elevated expression of the CN-dependent transcription factor nuclear factor of activated T cells 4 (NFAT4 (zeige NFATC3 ELISA Kits)
In studies of human and mouse pancreatic cells and tissue, we identified context-specific epigenetic regulation of NFATc1 activity as an important mechanism of pancreatic cell plasticity.
Immunoreceptor tyrosine-based inhibitory motif DC-STAMP (zeige TM7SF4 ELISA Kits) is a functional motif that regulates osteoclast differentiation through the NFATc1/Ca(2 (zeige CA2 ELISA Kits)+) axis.
TNF (zeige TNF ELISA Kits)/IL-6 (zeige IL6 ELISA Kits) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1, DNAX-activation protein 12 (zeige TYROBP ELISA Kits), and cell proliferation.
PRIP (zeige NCOA6 ELISA Kits) deficiency impairs osteoclast differentiation, particularly at the early stages, and PRIP (zeige NCOA6 ELISA Kits) stimulates osteoclast differentiation through calcium-calcineurin-NFATc1 signaling via regulating intracellular Ca(2 (zeige CA2 ELISA Kits)+)
data identified a novel role of SFKs in preventing aberrant NFAT1 (zeige NFAT1 ELISA Kits) activation in resting T cells, and suggest that maintaining this pool of active SFKs in therapeutic T cells may increase the efficacy of T cell therapies
Pathway analysis of the genes associated with the 46 CpG sites revealed an enrichment of immune system process genes, including LYST (zeige LYST ELISA Kits) (cg16962115, FDR = 1.24E-04), CADM1 (zeige CADM1 ELISA Kits) (cg21933078, FDR = 1.22E-02) and NFATC1 (cg06784563, FDR = 1.46E-02)
there is an NFATc1/ABCA1 (zeige ABCA1 ELISA Kits)-dependent mechanism in which local TNF (zeige TNF ELISA Kits) is sufficient to cause free cholesterol-dependent podocyte injury irrespective of TNF (zeige TNF ELISA Kits), TNFR1 (zeige TNFRSF1A ELISA Kits), or TNFR2 (zeige TNFRSF1B ELISA Kits) serum levels
NFATC1 transcription factor (NFATc1) expression is detected in prostate cancer (PCa (zeige FLVCR1 ELISA Kits)) specimens and PCa (zeige FLVCR1 ELISA Kits) cells but is absent in non-neoplastic human prostates and non-tumorigenic prostatic cells
DYRK1A phosphorylation of NFATc1/alphaA at S261, S278, S403 and S409 interfered with NFATc1 ubiquitination and ubiquitin-proteasome degradation.
NFATC1 rs3894049 GC was a risk factor for acute rejection in renal transplant recipients compared with CC carriers.
revealed more than 170 NFAT-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 and NFATc2 (zeige NFAT1 ELISA Kits) in T cells, such as Raptor (zeige RPTOR ELISA Kits), CHEK1 (zeige CHEK1 ELISA Kits), CREB1 (zeige CREB1 ELISA Kits), RUNX1 (zeige RUNX1 ELISA Kits), SATB1 (zeige SATB1 ELISA Kits), Ikaros (zeige IKZF1 ELISA Kits), and Helios (zeige ZNFN1A2 ELISA Kits).
NFATc1 silencing regulates the cell cycle.
Study showed that luteolin and apigenin effectively maintain pluripotency of PDLCs through activation of Oct-4 (zeige POU5F1 ELISA Kits)/Sox2 (zeige SOX2 ELISA Kits) signal via NFATc1.
In calf pulmonary artery endothelial cells, extracellular application of vasoactive agonist ATP or calcium ionophore ionomycin generates a rise in intracellular calcium that induces nuclear localization of NFATc1.
regulation of nuclear localization of NFAT is isoform-specific and dependent on nuclear export processes
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
, nuclear factor of activated T-cells, cytosolic component 1
, nuclear factor of activated T-cells calcineurin-dependent 1
, nuclear factor of activated T-cells, cytoplasmic 1
, nuclear factor of activated T-cells, cytoplasmic 1-like
, NFAT transcription complex cytosolic component
, transcription factor NF-ATc
, transcription factor NFATmac