anti-Human NFATC1 Antikörper für Flow Cytometry

Recommended NFATC1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1) Antikörper
  • nf-atc
  • nfat2
  • nfatc
  • si:ch211-198c22.2
  • NFATC1
  • 2210017P03Rik
  • AI449492
  • AV076380
  • NF-ATc
  • NFAT2
  • NFATc
  • Nfatcb
  • NF-ATC
  • NF-ATc1
  • NFAT
  • NFATmac
  • nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
  • nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
  • NFATC1
  • nfatc1
  • Nfatc1
Epitop
AA 197-304
29
20
15
14
13
7
6
6
6
5
5
4
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
152
55
39
10
7
7
7
5
4
4
3
3
1
1
1
1
1
Wirt
Maus
105
46
1
Klonalität
Monoklonal
Konjugat
Dieser NFATC1 Antikörper ist konjugiert mit Alexa Fluor 488
5
4
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS), Mass Cytometry (CyTOF)
124
53
48
16
13
11
11
9
6
4
3
3
2
2
2
1
1
Hersteller
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Bilder

Produktnummer ABIN2657092
305,41 €
Zzgl. Versandkosten 20,00 € und MWSt
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
14.244509 ABIN2662815 FACS PE Mouse IgG1 AA 197-304 Anmelden zum Anzeigen 7A6 7
1 ABIN2666355 FACS Mouse IgG1 AA 197-304 Anmelden zum Anzeigen 7A6 8
1 ABIN2657093 FACS CyTOF Alexa Fluor 488 Mouse IgG1 AA 197-304 Anmelden zum Anzeigen 7A6 7
1 ABIN2662816 FACS PE Mouse IgG1 AA 197-304 Anmelden zum Anzeigen 7A6 7
1 ABIN2666356 FACS Mouse IgG1 AA 197-304 Anmelden zum Anzeigen 7A6 8
1 ABIN233537 GS ICC FACS IP WB Mouse IgG1 AA 1-654 Anmelden zum Anzeigen

anti-NFATC1 Antikörper für Flow Cytometry mit den meisten Publikationen

Ähnliche anti-NFATC1 Antikörper

Applikation / Reaktivität Human Maus Ratte (Rattus)
Immunofluorescence (fixed cells) (IF/ICC) 2 Antikörper 1 Antikörper 1 Antikörper
Simple Western (SimWes) 2 Antikörper 2 Antikörper
Western Blotting (WB) 124 Antikörper 34 Antikörper 21 Antikörper
Mass Cytometry (CyTOF) 2 Antikörper 2 Antikörper 2 Antikörper
Immunoprecipitation (IP) 11 Antikörper 5 Antikörper 2 Antikörper
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 16 Antikörper 5 Antikörper 4 Antikörper
Immunohistochemistry (IHC) 48 Antikörper 18 Antikörper 14 Antikörper

General

Antigen Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1) Antikörper
Epitop AA 197-304
(29), (20), (15), (14), (13), (7), (6), (6), (6), (5), (5), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(152), (55), (39), (10), (7), (7), (7), (5), (4), (4), (3), (3), (1), (1), (1), (1), (1)
Wirt Maus
(105), (46), (1)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser NFATC1 Antikörper ist konjugiert mit Alexa Fluor 488
(5), (4), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Flow Cytometry (FACS), Mass Cytometry (CyTOF)
(124), (53), (48), (16), (13), (11), (11), (9), (6), (4), (3), (3), (2), (2), (2), (1), (1)
Pubmed 7 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-NFATC1 Antikörper

Target Details NFATC1 Anwendungsinformationen Handhabung ProductDetails: References for anti-NFATC1 antibody (ABIN2657092) Bilder
Reinigung The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
Klon 7A6
Isotyp IgG1

Target Details NFATC1

Produktdetails anti-NFATC1 Antikörper Anwendungsinformationen Handhabung ProductDetails: References for anti-NFATC1 antibody (ABIN2657092) Bilder zurück nach oben
Antigen
Andere Bezeichnung NFATc1 (NFATC1 Antibody Abstract)
Hintergrund The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. The protein complex consists of NFAT1, NFAT2 (NFATc1 or NFATc), NFAT3, and NFAT4. All members of this family are transcription factors with a Rel homology domain and regulate gene transcription in concert with AP-1 (Jun/Fos) to orchestrate an effective immune response. NFAT proteins are predominantly expressed in cells of the immune system but are also expressed in skeletal muscle, keratinocytes and adipocytes, regulating cell differentiation programs in these cells. In resting cells, NFAT proteins are heavily phosphorylated and localized in the cytoplasm. Increased intracellular calcium concentrations activate the calcium/calmodulin-dependent serine phosphatase calcineurin, which dephosphorylates NFAT proteins, resulting in their subsequent translocation to the nucleus. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
Forschungsgebiet Signaling
Pathways RTK Signalweg, WNT Signalweg, TCR Signaling, Fc-epsilon Rezeptor Signalübertragung

Anwendungsinformationen

Produktdetails anti-NFATC1 Antikörper Target Details NFATC1 Handhabung ProductDetails: References for anti-NFATC1 antibody (ABIN2657092) Bilder zurück nach oben
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-NFATC1 Antikörper Target Details NFATC1 Anwendungsinformationen ProductDetails: References for anti-NFATC1 antibody (ABIN2657092) Bilder zurück nach oben
Konzentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Protect from prolonged exposure to light. Do not freeze.
Lagerung 4 °C
Informationen zur Lagerung The antibody solution should be stored undiluted between 2°C and 8°C

ProductDetails: References for anti-NFATC1 antibody (ABIN2657092)

Produktdetails anti-NFATC1 Antikörper Target Details NFATC1 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Zhao, Wang, Liu, He, Jia: "NFATc1: functions in osteoclasts." in: The international journal of biochemistry & cell biology, Vol. 42, Issue 5, pp. 576-9, 2010

Brandt, Liman, Bendfeldt, Mueller, Reinke, Radbruch, Worm, Baumgrass: "Whole blood flow cytometric measurement of NFATc1 and IL-2 expression to analyze cyclosporine A-mediated effects in T cells." in: Cytometry. Part A : the journal of the International Society for Analytical Cytology, Vol. 77, Issue 7, pp. 607-13, 2010

Serfling, Berberich-Siebelt, Avots: "NFAT in lymphocytes: a factor for all events?" in: Science's STKE : signal transduction knowledge environment, Vol. 2007, Issue 398, pp. pe42, 2007

Hogan, Chen, Nardone, Rao: "Transcriptional regulation by calcium, calcineurin, and NFAT." in: Genes & development, Vol. 17, Issue 18, pp. 2205-32, 2003

Timmerman, Healy, Ho, Chen, Goodnow, Crabtree: "Redundant expression but selective utilization of nuclear factor of activated T cells family members." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 6, pp. 2735-40, 1997

Hoey, Sun, Williamson, Xu: "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins." in: Immunity, Vol. 2, Issue 5, pp. 461-72, 1995

Northrop, Ullman, Crabtree: "Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex." in: The Journal of biological chemistry, Vol. 268, Issue 4, pp. 2917-23, 1993

Bilder

Produktdetails anti-NFATC1 Antikörper Target Details NFATC1 Anwendungsinformationen Handhabung ProductDetails: References for anti-NFATC1 antibody (ABIN2657092) zurück nach oben
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-NFATC1 Antikörper (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1) (AA 197-304) (Alexa Fluor 488) (ABIN2657092) anti-Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1) (AA 197-304) antibody (Alexa Fluor 488)