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Human Neuregulin 1 Protein expressed in Human Cells - ABIN2004422
Holmes, Sliwkowski, Akita, Henzel, Lee, Park, Yansura, Abadi, Raab, Lewis: Identification of heregulin, a specific activator of p185erbB2. in Science (New York, N.Y.) 1992
Show all 2 Pubmed References
Human Neuregulin 1 Protein expressed in Wheat germ - ABIN1307066
Gu, Duce, Valova, Wong, Bush, Petrou, Wiley: P2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in cerebrospinal fluid. in The Journal of biological chemistry 2012
These results collectively suggest that sustained activation of Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling in endothelial cells might be a cause of heart failure through suppressing neuregulin-ErbB (zeige EGFR Proteine) signaling.
These results suggest that the neuropsin (zeige KLK8 Proteine)-NRG1 signaling system has a role in pathological processes underlying temporal lobe epilepsy by regulating the activity of parvalbumin (zeige PVALB Proteine)-expressing interneurons, and that neuropsin (zeige KLK8 Proteine) regulates E/I balance and gamma oscillations through NRG1-ErbB4 (zeige ERBB4 Proteine) signaling toward parvalbumin (zeige PVALB Proteine)-expressing interneurons.
we show that the antifibrotic effect of neuregulin-1 is at least partially mediated through anti-inflammatory activity, linked to receptor tyrosine-protein kinase erbB-4 (zeige ERBB4 Proteine) activation in macrophages
Results show that at ventral hippocampus-nucleus accumbens synapses, presynaptic type III Nrg1 bidirectional signaling controls the establishment of ventral hippocampus-nucleus accumbens glutamatergic synapses. Type III Nrg1 back-signaling contributes to functional synaptic vesicle clustering and neurotransmitter vesicle release.
Results demonstrate for the first time a link between a mutation of a schizophrenia risk gene, neuregulin 1 and altered neuronal resonance properties in sensory cortex.
findings reveal molecular, cellular, and circuit mechanisms of NRG1/ErbB4 (zeige ERBB4 Proteine) in regulating the initiation of critical period visual cortical plasticity.
Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.
These results demonstrate for the first time in vivo interplay between Nrg1 and endocannabinoids in the brain.
Study revealed that bed nucleus of the stria terminalis NRG1-ErbB4 (zeige ERBB4 Proteine) signaling is involved in regulating anxiety, and that blocking this pathway produced anxiety-like behavior.
NRG1 enhanced excitatory drive onto fast spiking interneurons, which inhibited ocular dominance plasticity in juveniles but rescued plasticity in transgenics with hypoexcitable fast-spiking interneurons
NRG1 genotype is associated with substance use.
Significant genetic risk for Hirschsprung disease (HSCR (zeige EDNRB Proteine)) was imparted by rs2435357 and rs2506030 at RET (zeige RET Proteine) and by rs12707682 at SEMA3 in a Chinese population. No evidence was found of a genetic association between HSCR (zeige EDNRB Proteine) and either of the NRG1 SNPs rs7835688 and rs16879552, at either allele or genotype level.
High HRG1 expression is associated with breast cancer.
Results showed that heregulin-1ss mRNA was downregulated in 82 % of patients with hepatocellular carcinoma.
NRG1/ErbB2 (zeige ERBB2 Proteine)/Src (zeige SRC Proteine)/PTK2 (zeige PTK2 Proteine) signaling pathway may be a novel regulator of keloid fibroblast migration.
The plasma soluble NRG1 level was significantly higher in mild and moderate Alzheimer's disease patients compared to controls.
Data indicate a role for AXL receptor tyrosine kinase (AXL (zeige AXL Proteine)) in regulating the nuclear translocation of epidermal growth factor receptor (EGFR (zeige EGFR Proteine)) and suggest that AXL (zeige AXL Proteine)-mediated SRC (zeige SRC Proteine) family kinases (SFKs) and neuregulin-1 (NRG1) expression promote this process.
NRG1FISH detection should be considered in patients with IMA pan-negative for known driver oncogenes. These results might suggest that NRG1 fusion is more frequent in IMA from Asian patient.
Results suggest genetic variation at the 5' and 3' ends of NRG1 are associated with schizophrenia. [Meta-Analysis]
Nrg1 acts as an axonal signal that drives virtually all stages of Schwann cell development and myelination.Nrg1 plays important role in the peripheral nerve injury and nerve repair.[review]
Data suggest that epidermal growth factor receptor (zeige EGFR Proteine) B [ErbB (zeige EGFR Proteine)] isoforms and their ligands (epidermal growth factor (zeige EGF Proteine) [EGF (zeige EGF Proteine)], amphiregulin (zeige AREG Proteine) [AREG (zeige AREG Proteine)], and neuregulin-1 [NRG1]) are expressed in uteroplacental tissues in mid- and late-phases of pregnancy.
Cloning of a novel isoform of NRG1 (IgNRG1beta2) containing an immunoglobulin-like domain which is probably essential for efficient interaction with ErbB (zeige EGFR Proteine) receptors.
The present research focused on morphological distribution of Nrg1 and its receptors, ErbB2 (zeige ERBB2 Proteine) and ErbB4 (zeige ERBB4 Proteine), in main gastrointestinal tissues of the non-human primate rhesus monkey.
we observed the activation of Notch (zeige NOTCH1 Proteine) signaling in cardiomyocytes adjacent to those undergoing apical constriction, and we showed that this activation is positively regulated by Neuregulin signaling.
these results suggest that Nrg1 is not the primary effector of trabeculation and/or that other EGF (zeige EGF Proteine)-like ligand(s) activates the ErbB2 (zeige ERBB2 Proteine)/ErbB4 (zeige ERBB4 Proteine) pathway, either through functioning as the primary ligand or acting in a redundant manner. Overall, our work provides an example of cross-species differences in EGF (zeige EGF Proteine) family member requirements for an evolutionary conserved process.
Notch1 (zeige NOTCH1 Proteine) activation induces expression of ephrin b2a (efnb2a (zeige EFNB2 Proteine)) and neuregulin 1 (nrg1) in the endocardium to promote trabeculation and forced Notch (zeige NOTCH1 Proteine) activation in the absence of cardiac contraction rescues efnb2a (zeige EFNB2 Proteine) and nrg1 expression
These findings identify Nrg1 as a potent, induced mitogen for the endogenous adult heart regeneration program.
These results demonstrate that Nrg1 type III is an essential signal that controls Schwann cell migration to ensure that these glia are present in the correct numbers and positions in developing nerves.
ErbB3 (zeige ERBB3 Proteine) signaling is required for normal migration of trunk, but not cranial, neural crest cells
Disc1 (zeige DISC1 Proteine) and nrg1 function in controlling development of oligodendrocytes and neurones from olig2 (zeige OLIG2 Proteine)-expressing precursor cells.
NRG1 and PI3K functionally interact with ErbB2 (zeige ERBB2 Proteine) and ErbB3 (zeige ERBB3 Proteine) during regeneration
The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD).
, pro-neuregulin-1, membrane-bound isoform
, type I neuregulin 1
, type III neuregulin 1
, neuregulin 1
, glial growth factor
, heregulin, alpha (45kD, ERBB2 p185-activator)
, neu differentiation factor
, neuregulin 1 type IV beta 1a
, neuregulin 1 type IV beta 3
, sensory and motor neuron derived factor
, neuregulin 1 type III beta 3
, membrane-bound isoform
, neuregulin 1 alpha isoform