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anti-Mouse (Murine) Neuregulin 1 Antikörper:
anti-Human Neuregulin 1 Antikörper:
anti-Rat (Rattus) Neuregulin 1 Antikörper:
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Human Polyclonal Neuregulin 1 Primary Antibody für WB - ABIN516692
Nordqvist, Kårehed, Hambiliki, Wånggren, Stavreus-Evers, Akerud: The presence of histidine-rich glycoprotein in the female reproductive tract and in embryos. in Reproductive sciences (Thousand Oaks, Calif.) 2010
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Human Polyclonal Neuregulin 1 Primary Antibody für FACS, IHC (p) - ABIN390160
Ritch, Carroll, Sontheimer: Neuregulin-1 enhances motility and migration of human astrocytic glioma cells. in The Journal of biological chemistry 2003
Show all 4 Pubmed References
These results suggest that the neuropsin (zeige KLK8 Antikörper)-NRG1 signaling system has a role in pathological processes underlying temporal lobe epilepsy by regulating the activity of parvalbumin (zeige PVALB Antikörper)-expressing interneurons, and that neuropsin (zeige KLK8 Antikörper) regulates E/I balance and gamma oscillations through NRG1-ErbB4 (zeige ERBB4 Antikörper) signaling toward parvalbumin (zeige PVALB Antikörper)-expressing interneurons.
we show that the antifibrotic effect of neuregulin-1 is at least partially mediated through anti-inflammatory activity, linked to receptor tyrosine-protein kinase erbB-4 (zeige ERBB4 Antikörper) activation in macrophages
Results show that at ventral hippocampus-nucleus accumbens synapses, presynaptic type III Nrg1 bidirectional signaling controls the establishment of ventral hippocampus-nucleus accumbens glutamatergic synapses. Type III Nrg1 back-signaling contributes to functional synaptic vesicle clustering and neurotransmitter vesicle release.
Results demonstrate for the first time a link between a mutation of a schizophrenia risk gene, neuregulin 1 and altered neuronal resonance properties in sensory cortex.
findings reveal molecular, cellular, and circuit mechanisms of NRG1/ErbB4 (zeige ERBB4 Antikörper) in regulating the initiation of critical period visual cortical plasticity.
Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.
These results demonstrate for the first time in vivo interplay between Nrg1 and endocannabinoids in the brain.
Study revealed that bed nucleus of the stria terminalis NRG1-ErbB4 (zeige ERBB4 Antikörper) signaling is involved in regulating anxiety, and that blocking this pathway produced anxiety-like behavior.
NRG1 enhanced excitatory drive onto fast spiking interneurons, which inhibited ocular dominance plasticity in juveniles but rescued plasticity in transgenics with hypoexcitable fast-spiking interneurons
we described a RET (zeige RET Antikörper)-ER81 (zeige ETV1 Antikörper)-Neuregulin1 signaling pathway in neurons innervating Pacinian corpuscle somatosensory end organs, which is essential for communication between the innervating axon and the end organ
NRG1 genotype is associated with substance use.
Significant genetic risk for Hirschsprung disease (HSCR (zeige EDNRB Antikörper)) was imparted by rs2435357 and rs2506030 at RET (zeige RET Antikörper) and by rs12707682 at SEMA3 in a Chinese population. No evidence was found of a genetic association between HSCR (zeige EDNRB Antikörper) and either of the NRG1 SNPs rs7835688 and rs16879552, at either allele or genotype level.
High HRG1 expression is associated with breast cancer.
Results showed that heregulin-1ss mRNA was downregulated in 82 % of patients with hepatocellular carcinoma.
NRG1/ErbB2 (zeige ERBB2 Antikörper)/Src (zeige SRC Antikörper)/PTK2 (zeige PTK2 Antikörper) signaling pathway may be a novel regulator of keloid fibroblast migration.
The plasma soluble NRG1 level was significantly higher in mild and moderate Alzheimer's disease patients compared to controls.
Data indicate a role for AXL receptor tyrosine kinase (AXL (zeige AXL Antikörper)) in regulating the nuclear translocation of epidermal growth factor receptor (EGFR (zeige EGFR Antikörper)) and suggest that AXL (zeige AXL Antikörper)-mediated SRC (zeige SRC Antikörper) family kinases (SFKs) and neuregulin-1 (NRG1) expression promote this process.
NRG1FISH detection should be considered in patients with IMA pan (zeige SUPT6H Antikörper)-negative for known driver oncogenes. These results might suggest that NRG1 fusion is more frequent in IMA from Asian patient.
Results suggest genetic variation at the 5' and 3' ends of NRG1 are associated with schizophrenia. [Meta-Analysis]
Nrg1 acts as an axonal signal that drives virtually all stages of Schwann cell development and myelination.Nrg1 plays important role in the peripheral nerve injury and nerve repair.[review]
Data suggest that epidermal growth factor receptor (zeige EGFR Antikörper) B [ErbB (zeige EGFR Antikörper)] isoforms and their ligands (epidermal growth factor (zeige EGF Antikörper) [EGF (zeige EGF Antikörper)], amphiregulin (zeige AREG Antikörper) [AREG (zeige AREG Antikörper)], and neuregulin-1 [NRG1]) are expressed in uteroplacental tissues in mid- and late-phases of pregnancy.
Cloning of a novel isoform of NRG1 (IgNRG1beta2) containing an immunoglobulin-like domain which is probably essential for efficient interaction with ErbB (zeige EGFR Antikörper) receptors.
The present research focused on morphological distribution of Nrg1 and its receptors, ErbB2 (zeige ERBB2 Antikörper) and ErbB4 (zeige ERBB4 Antikörper), in main gastrointestinal tissues of the non-human primate rhesus monkey.
we observed the activation of Notch (zeige NOTCH1 Antikörper) signaling in cardiomyocytes adjacent to those undergoing apical constriction, and we showed that this activation is positively regulated by Neuregulin signaling.
these results suggest that Nrg1 is not the primary effector of trabeculation and/or that other EGF (zeige EGF Antikörper)-like ligand(s) activates the ErbB2 (zeige ERBB2 Antikörper)/ErbB4 (zeige ERBB4 Antikörper) pathway, either through functioning as the primary ligand or acting in a redundant manner. Overall, our work provides an example of cross-species differences in EGF (zeige EGF Antikörper) family member requirements for an evolutionary conserved process.
Notch1 (zeige NOTCH1 Antikörper) activation induces expression of ephrin b2a (efnb2a (zeige EFNB2 Antikörper)) and neuregulin 1 (nrg1) in the endocardium to promote trabeculation and forced Notch (zeige NOTCH1 Antikörper) activation in the absence of cardiac contraction rescues efnb2a (zeige EFNB2 Antikörper) and nrg1 expression
These findings identify Nrg1 as a potent, induced mitogen for the endogenous adult heart regeneration program.
These results demonstrate that Nrg1 type III is an essential signal that controls Schwann cell migration to ensure that these glia are present in the correct numbers and positions in developing nerves.
ErbB3 (zeige ERBB3 Antikörper) signaling is required for normal migration of trunk, but not cranial, neural crest cells
Disc1 (zeige DISC1 Antikörper) and nrg1 function in controlling development of oligodendrocytes and neurones from olig2 (zeige OLIG2 Antikörper)-expressing precursor cells.
NRG1 and PI3K functionally interact with ErbB2 (zeige ERBB2 Antikörper) and ErbB3 (zeige ERBB3 Antikörper) during regeneration
The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD).
, pro-neuregulin-1, membrane-bound isoform
, type I neuregulin 1
, type III neuregulin 1
, neuregulin 1
, glial growth factor
, heregulin, alpha (45kD, ERBB2 p185-activator)
, neu differentiation factor
, neuregulin 1 type IV beta 1a
, neuregulin 1 type IV beta 3
, sensory and motor neuron derived factor
, neuregulin 1 type III beta 3
, membrane-bound isoform
, neuregulin 1 alpha isoform