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Human MET Protein expressed in Human Cells - ABIN2003241
Bottaro, Rubin, Faletto, Chan, Kmiecik, Vande Woude, Aaronson: Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. in Science (New York, N.Y.) 1991
Show all 7 Pubmed References
The oleocanthal-based homovanillyl sinapate is a novel c-Met inhibitor which reduced tumor growth orthotopic model of triple negative breast cancer.
Studies indicate that miR-182 negatively regulated Met via direct binding to the Met 3'-untranslated region (3'-UTR).
Selective MET tyrosine kinase (zeige TXK Proteine) inhibitor SAR125844 has significant antitumour activity in patients with MET-amplified non-small cell lung carcinoma.
miR (zeige MLXIP Proteine)-34a reconstitution in DMPM cells significantly inhibited proliferation and tumorigenicity, induced an apoptotic response, and declined invasion ability, mainly through the down-regulation of c-MET and AXL (zeige AXL Proteine) and the interference with the activation of downstream signaling.
The hepatocyte growth factor (HGF (zeige HGF Proteine))-MET receptor tyrosine kinase (zeige RET Proteine) signaling pathway
Crizotinib is active and well tolerated in advanced, metastatic papillary renal cell carcinoma (zeige MOK Proteine) type 1, achieving objective responses and long-lasting disease control in patients with MET mutations or amplification.
Data show that cancer-associated fibroblasts (CAFs (zeige TBX1 Proteine))-derived hepatocyte growth factor (HGF (zeige HGF Proteine)) or recombinant HGF (zeige HGF Proteine) activated c-Met/phosphoinositide 3-kinase (PI3K (zeige PIK3CA Proteine))/Akt (zeige AKT1 Proteine) and glucose-regulated protein 78 (GRP78 (zeige HSPA5 Proteine)) signalling pathways in ovarian cancer cells.
Data show that MET is the direct target of miR (zeige MLXIP Proteine)-206 in lung cancer cells.
Results indicate that miR (zeige MLXIP Proteine)-329 played a pivotal role in lung cancer through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic MET.
nMet accelerated HCC (zeige FAM126A Proteine) tumorigenesis and metastasis via the activation of TAK1 (zeige MAP3K7 Proteine)/NF-kappaB (zeige NFKB1 Proteine) pathway.
MET promoted the development of squamous tumors by stimulating the synthesis and release of ligands that activate the epidermal growth factor receptor (EGFR (zeige EGFR Proteine)).
through the activation of EGFR, MET activation parallels a RAS pathway to contribute to human and mouse cutaneous cancers.
Results show that c-MET expression is significantly low in pancreatic neuroendocrine tumors (PNETs) and is under the regulation of Meg3-mediated transcriptional and epigenetic mechanisms which contributes to the pathogenesis of PNETs.
Findings indicate a role for the hepatocyte growth factor receptor HGFR/c-MET pathway in neutrophil recruitment and function and suggest that c-MET inhibitor co-treatment may improve responses to cancer immunotherapy in settings beyond c-MET-dependent tumors.
Results demonstrate a new mechanism for the modulation of synapse formation, whereby MET activation induces an alignment of presynaptic and postsynaptic elements that are necessary for assembly and formation of functional synapses by subsets of neocortical neurons that express MET/beta-catenin (zeige CTNNB1 Proteine) complex.
MET signaling regulates intestinal homeostasis and regeneration, as well as adenoma formation. These activities of MET are promoted by the stem cell CD44 (zeige CD44 Proteine) isoform CD44v4-10.
a c-Met/ETS-1 (zeige ETS1 Proteine)/matrix metalloproteinase-14 (MMP-14 (zeige MMP14 Proteine)) axis that controls VE-cadherin (zeige CDH5 Proteine) degradation, endothelial mesenchymal transition, and vascular abnormality.
We found the roles of hepatocyte growth factor (HGF (zeige HGF Proteine)) signaling in stria vascularis development for the first time and that lack of HGF (zeige HGF Proteine) signaling in the inner ear leads to profound hearing loss in the mouse. Our findings reveal a novel mechanism that may underlie human deafness DFNB39 (zeige HGF Proteine) and DFNB97. Our findings reveal an additional example of context-dependent c-MET signaling diversity, required here for proper cellular inva
c-Met has been found to attenuate lung injury and apoptosis in bronchial epithelial cells.
In this paper, we demonstrate a potential biochemical mechanism for such phenomena by showing that c-Met receptors promote the tyrosine phosphorylation of RalGDS (zeige RALGDS Proteine) at Y752 in its RBD (zeige CACNA1D Proteine), which blocks the binding of Ras to RalGDS (zeige RALGDS Proteine).
possible cooperative role of the EGF (zeige EGF Proteine) and HGF (zeige HGF Proteine) pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.
, HGF/SF receptor
, SF receptor
, hepatocyte growth factor receptor
, met proto-oncogene tyrosine kinase
, proto-oncogene c-Met
, scatter factor receptor
, tyrosine-protein kinase Met
, HGF receptor c-Met