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c-kit-positive cells derived from right atrium tissue were associated with serum BNP
For hot spots in KIT and PDGFRA (zeige PDGFRA Proteine) genes, 23 out of 146 KIT/PDGFRA (zeige PDGFRA Proteine) wild-type cases carried mutations according to next-generation sequencing (NGS).
KIT and DNMT1 (zeige DNMT1 Proteine) co-expression promotes, whereas dual inactivation of them suppresses, lung cancer cell proliferation and metastatic growth in vitro and in vivo, in a synergistic manner.
Data indicate that BRAF, NRAS and C-KIT melanomas constitute distinct clinico-pathological entities.
our data established CD117 as a direct target of miR (zeige MLXIP Proteine)-34-5p and demonstrated that this regulation interferes with several CD117-mediated effects on osteosarcoma cells
Results indicate anthraquinone derivative AQ1 as a promising compound for the target therapy of c-KIT-dependent tumors.
Data show that afatinib resistant clones were selectively killed by knock down of ERBB3 (zeige ERBB3 Proteine) + c-MET + c-KIT, but not by the individual or doublet knock down combinations, and the combination of afatinib with the SRC (zeige SRC Proteine) family inhibitor dasatinib killed afatinib resistant H1975 cells in a greater than additive fashion.
Podocalyxin-like protein 1 is a relevant marker for human c-kit(pos) cardiac stem cells.(
High fertilization (56.06%) and pregnancy (41.7%) rates accomplished in this study following ICSI-AOA (zeige APTX Proteine) indicated that expression profiles of PLCzeta (zeige PLCz1 Proteine), PAWP (zeige WBP2NL Proteine), and TR-KIT were low in globozoospermic individuals
Different types of cancers harbor mutations in the oncogene (zeige RAB1A Proteine) KIT
Artificially applied c-kit(+) cells interact with the target organ endothelium following ischemia reperfusion injury. This interaction seems to depend on TLR-MyD88 (zeige MYD88 Proteine) signaling.
a critical role for PRL2 phosphatase in mediating Notch and c-Kit signals in early T cell progenitors, is reported.
These results suggest that CD44 (zeige CD44 Proteine)(+)CD117(+) T cells are stem cells and a specific T-cell phenotype that initially develops in the thymus, but they do not progress through DN3 and DN4 stages, lack a DP stage, and potently suppress T-cell proliferation and modulate the CTLA-4 (zeige CTLA4 Proteine) pathway.
we studied the efficacy of ACK2, an antibody that blocks KIT, followed by low-dose irradiation as a preconditioning regimen for hematopoietic cell transplantation using a murine model of Mucopolysaccharidosis type II.
C-kit-positive hematopoietic stem/progenitor cells expressed significantly higher of Nox1 (zeige NOX1 Proteine) and catalase (zeige CAT Proteine), but less of lactoperoxidase (zeige LPO Proteine) than in matured mononuclear cells.
c-KIT signaling regulates self-renewal capacity and prevents neurodifferentiation in culture.
These findings identify functional redundancy among Kit-dependent hematopoietic lineages and establish an unanticipated capacity of megakaryocytes to mediate IL-1 (zeige IL1A Proteine)-driven systemic inflammatory disease.
WNT (zeige WNT2 Proteine) signaling at an early stage (E12 (zeige ELSPBP1 Proteine)-E15) of submandibular salivary gland (SMG (zeige SNRPG Proteine)) development inhibits end bud morphogenesis and differentiation into proacini by suppressing Kit expression.
c-kit can reduce inflammation, positively modulate airway remodeling, and improve function in a mouse model of airway hyperresponsiveness
Kit inactivation within oocytes also led to premature ovarian failure, albeit via a contrasting phenotype. Despite normal initial complements of primordial follicles, oocytes remained dormant with arrested oocyte maturation. Foxo3 (zeige FOXO3 Proteine) protein localization in the nucleus versus cytoplasm explained both mutant phenotypes.
FGF7 (zeige FGF7 Proteine) may be an important regulator for oocyte growth and its action is mediated via the KIT/KITLG (zeige KITLG Proteine) signaling pathway.
mRNA expression of c-kit and SCF was decreased in gallbladder tissues in the HCD group. Consistent with the findings of RT-PCR, a lower expression level of c-kit and SCF protein was also observed in HCD animals.
Delayed enrichment for c-kit and inducing cardiac differentiation attenuated protective effects of BMSCs' transplantation in pig model of acute myocardial infarction.
Pravastatin improves function in hibernating myocardium by mobilizing CD133+ and cKit+ bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle.
c-kit is primarily expressed in the spermatogonia and spermatocytes of goat testes.
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
mast/stem cell growth factor receptor Kit
, p145 c-kit
, piebald trait protein
, proto-oncogene c-Kit
, proto-oncogene tyrosine-protein kinase Kit
, soluble KIT variant 1
, tyrosine-protein kinase Kit
, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
, Dominant white spotting
, Steel Factor Receptor
, c-kit proto-oncogene protein
, dominant spotting
, spotted sterile male
, c-kit receptor tyrosine kinase
, mast/stem cell growth factor receptor
, protein kinase
, c-kit receptor
, mast cell growth factor receptor
, c-KIT gene1
, receptor tyrosine kinase c-kit
, Mast/stem cell growth factor receptor
, Proto-oncogene c-Kit
, Tyrosine-protein kinase Kit
, caprine c-kit protein