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Human IGF1 Protein expressed in Escherichia coli (E. coli) - ABIN413398
Robertson, Zhu, Wu: Cellular distribution of the IGF-1R in corneal epithelial cells. in Experimental eye research 2011
Show all 4 Pubmed References
Human IGF1 Protein expressed in Escherichia coli (E. coli) - ABIN803884
de Waal, Leal, García-López, Liarte, de Jonge, Hinfray, Brion, Schulz, Bogerd: Oestrogen-induced androgen insufficiency results in a reduction of proliferation and differentiation of spermatogonia in the zebrafish testis. in The Journal of endocrinology 2009
Show all 2 Pubmed References
Human IGF1 Protein expressed in Sf-9 cells - ABIN935729
Ablonczy, Crosson: VEGF modulation of retinal pigment epithelium resistance. in Experimental eye research 2007
the dipeptide Pro-Asp (zeige ASIP Proteine) promoted IGF-1 secretion and expression in hepatocytes.
Genetic variants in the IGF1 and IGF1R (zeige IGF1R Proteine) genes might not be associated with high myopia in Han Chinese. Further studies are needed to verify the possible function of IGF1 and IGF1R (zeige IGF1R Proteine) in the development of myopia.
The serum levels of IGF-1 seem to be increased in bipolar disorder patients (248.84+/-104.91ng/mL) compared to controls (169.18+/-74.16ng/mL).
In the present study of older adults, there was some evidence that moderate levels of IGF-1 levels conferred a reduced risk of depression.
The cotreatment of neonate skin fibroblast cultures with galactose and Gal-1 (zeige LGALS1 Proteine)-P significantly increased cellular levels of NO and iNOS (zeige NOS2 Proteine) protein expression, and decreased IGF-1 mRNA levels. Treatment with L-NAME, a NOS (zeige NOS1 Proteine) inhibitor, significantly alleviated a galactose/Gal-1 (zeige LGALS1 Proteine)-P-induced decrease in IGF-1 mRNA levels. These results suggest that NO mediates the downregulation of IGF-1 by Gal-1 (zeige LGALS1 Proteine)-P/galactose.
Lower circulating IGF-I is associated with better cognitive function in females with exceptional longevity, with no detriment to skeletal muscle mass and function.
The findings indicated that miR (zeige MLXIP Proteine)-135a promotes cell apoptosis and inhibits cell proliferation, migration, invasion and tumor angiogenesis by targeting IGF-1 gene through the IGF-1/PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling pathway in non-small cell lung cancer.
Enhancing IGF-1 expression by astrocytes provided hippocampal neuroprotection and improved memory and motor function after traumatic brain injury. Delivering IGF-1 through reactive astrocytes targeted IGF-1 overexpression to the damaged hippocampus, producing a progressive increase in IGF-1 over 72 h which led to activation of the Akt (zeige AKT1 Proteine) pro-survival pathway and reduced hippocampal neuron loss in multiple regions.
IGF-1 signaling is essential for sustaining cancer cell viability by stimulating both mitochondrial biogenesis and turnover through BNIP3 (zeige BNIP3 Proteine) induction. This core mitochondrial protective signal is likely to strongly influence responses to therapy and the phenotypic evolution of cancer.
Enhanced study of the role of IIS pathway and epigenetic mechanisms that regulate aging may facilitate progressive prevention and treatment of human age-related diseases.
the dipeptide Pro-Asp (zeige C3 Proteine) promoted IGF-1 secretion and expression in hepatocytes.
miR-18a suppresses the expression of Igf1 in a 3'UTR-dependent manner
down-regulation of IGF-1 expression and signaling is involved in FD-induced cell cycle arrest and apoptosis in HT-22 hippocampal neuron cells
Study demonstrates that GH/IGF-I, somatostatin (zeige SST Proteine)/cortistatin (zeige CORT Proteine) and ghrelin (zeige GHRL Proteine) systems expression is altered in mammary gland during fasting, suggesting a relevant role in coordinating its response to metabolic stress, wherein endogenous cortistatin (zeige CORT Proteine) might be essential for an appropriate response.
The specific aim of the present work was to study whether the partial IGF-1 deficiency influences heart and/or coronary circulation, comparing vasoactive factors before and after of ischemia-reperfusion (I/R).
Data (including data from studies using heterozygous transgenic mice) suggest that gene expression in liver is altered in a model of inflammation of liver due to partial deficiency of Igf1; this leads to over-expression of Igf1 receptor, inflammation mediators, and acute-phase proteins, but under-expression of cytoskeletal proteins, extracellular matrix proteins, and tight junction proteins.
Findings indicate that the energy-sensing LKB1 (zeige STK11 Proteine)-AMPK (zeige PRKAA1 Proteine) pathway regulates IGF1 secretion in mouse primary hepatocytes, which in turn regulates activation of the IGF1R (zeige IGF1R Proteine)-PKB (zeige AKT2 Proteine) pathway.
These results demonstrate that a greater than additive effect is observed on the growth of skeletal muscle and in the reduction of body fat when myostatin (zeige MSTN Proteine) is absent and IGF1 is in excess (zeige RCC1 Proteine), and that myostatin (zeige MSTN Proteine) and IGF1 regulate skeletal muscle size, myofibre type and gonadal fat through distinct mechanisms.
Confirmation of the impairment of GH-IGF-1 release in hyperphagic MC4R (zeige MC4R Proteine) KO mice suggests a role for insulin (zeige INS Proteine) in regulating both the release of GH, but also in mediating growth during periods of physiologically suppressed GH-IGF-1 levels
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR (zeige FRAP1 Proteine) and PPARg (zeige PPARG Proteine). In summary, PPARg (zeige PPARG Proteine) plays an important role in the regulation of IGF-1 secretion and gene expression in response to dietary protein.
Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.
This study demonstrated that Up-regulation of IGF-1 in the frontal cortex of piglets exposed to an environmentally enriched arena.
Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF (zeige HGF Proteine) enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
Results show that expression changes of IGF1 genes were associated with C/EBP (zeige CEBPA Proteine) b expression during embryonic and postnatal development in porcine liver.
genetic association study suggests that the TC genotype of IGF-1 represents the selection genotype for smaller in size.
IGF-I coordinately regulates multiple cell signaling pathways that are critical to proliferation, migration and survival of trophectoderm cells during early pregnancy in pigs.
IGF-1 splice variant (mechano growth factor) is expressed within the growth plate, but the addition of its peptides was not associated with growth plate chondrocytes proliferation.
alpha-linolenic acid increased IGF-I secretion from hepatocytes.
Data suggest caloric restriction modifies response of ovarian granulosa cells to leptin (zeige LEP Proteine) on cell proliferation/apoptosis, MAP kinase (zeige MAPK1 Proteine) signaling, and release of hormones (estradiol and IGFI). The caloric restriction studies were conducted in rabbits; then, isolated rabbit granulosa cells were exposed to recombinant human leptin (zeige LEP Proteine). (IGF1 = insulin-like growth factor I)
Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction.
Our studies demonstrate that the active SVCT2 (zeige SLC23A2 Proteine) is expressed in IVD (zeige IVD Proteine) cells and that the expression of this transporter is regulated by growth factors IGF-1 and dexamethasone.
increased endogenous IGF1 and IGF2 expression by the blastocyst compensates for the loss of systemic insulin (zeige INS Proteine) and IGF.
IGF1 showed a significantly higher capacity to form the posterior mesoderm and primitive streak (stage 2 and 3) than blastocysts cultured without growth factors
Overall, IGF-1 promoted atherosclerosis by affecting endothelial function and aging.
Findings show similar regulatory growth hormone (GH (zeige GH1 Proteine)) and insulin-like growth factor 1 (IGF-1) responses in both Atlantic salmon and rainbow trout.
the present study assessed the combined impacts of estrogens and bacterial infection on the insulin (zeige INS Proteine)-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha (zeige TNF Proteine).
Nutrient availability, IGF-I, and genetic variation affect weight loss, in part through alterations of proteolytic pathways in rainbow trout.
Study demonstrated that IGF-I can stimulate egfr (zeige EGFR Proteine) expression in both follicles cell culture and intact follicles promoting oocyte maturation.
IGF-I-induced kitlga expression is inhibited by epidermal growth factor (zeige EGF Proteine), an oocyte-derived paracrine factor in the zebrafish follicle.
hypoxia causes PGC (zeige PGC Proteine) migration defect by inhibiting IGF signaling through the induction of IGFBP-1 (zeige IGFBPI Proteine)
Whereas hypoxia repressed the Igf1 receptor and its downstream Erk1/2 and Akt (zeige AKT1 Proteine) signaling activities, re-oxygenation restored their activities
IGF signalling influences expression of BMP2b (zeige BMP4 Proteine), a gene that plays an important role in zebrafish pattern formation
The insulin-like growth factor 1 gene can be differentially transcribed to yield two distinct IGF-1 mRNA transcripts
zebrafish XBP-1 (zeige XBP1 Proteine) spliced form not only activates genes responsible for protein folding, transporting, glycosylation and Endoplasmic Reticulum associated degradation but also activates anti-apoptosis signal via IGF1/Akt (zeige AKT1 Proteine) pathway in unfolded protein
Thus CR suppresses the hypertrophic PGC1alpha-4/IGF-1/AKT1 pathway while promoting activation of the calpain system.
IGF1 single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.
It has been shown that several specific genes which are differentially regulated, including IGF-1, might impact dairy fertility.
There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 (zeige STAT5A Proteine) ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.
Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle.
The association of IGF1, GH, and PIT1 (zeige POU1F1 Proteine) markers with growth and reproductive traits were assessed.
These findings strongly support the concept that IGF-1 upregulates LHR (zeige LHCGR Proteine) expression in granulosa cells and that IGF-1 is required for determining which follicle becomes dominant and acquires ovulatory capacity.
Insulin (zeige INS Proteine)-induced glucose uptake in lactating bovine mammary epithelial cells may involve the phosphatidylinositide 3-kinase- but not mitogen-activated protein kinase (zeige MAPK1 Proteine)-mediated signaling pathways.
Data show that individuals with insulin-like growth factor I (IGF-1) allele C had a significantly higher performance in production traits.
Data suggest that metabolism of IGF1, IGF2, and IGFBP3 (insulin-like growth factor binding protein-3 (zeige IGFBP3 Proteine)) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
The laminar cell types expressing insulin receptor (zeige INSR Proteine) and/or insulin-like growth factor-1 receptor (zeige IGF1R Proteine) and the effect of dietary carbohydrates on their expression are reported.
Increased expression of IGF-1 in female equine embryos. Sex-related influences on expression of the IGF system are probably related to a gradual X chromosome inactivation.
Somatomedin (IGF-I) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor (zeige IGF1R Proteine) is present in spermatogonia, spermatocytes and Leydig cells.
Hsp90 (zeige HSP90AB1 Proteine) inhibitor geldanamycin is used to assess age-related responses with IGF1 stimulation of chondrocytes.
Local IGF-1 might play a role in the lesion- and deafness-induced plasticity in FC and at AN/FC synapse following chronic kanamycin-induced deafness.
These results suggest the significant influence of the IGF1 gene on prolificacy in goats and identified SNPs would benefit the selection of prolific animals in future breeding programs.
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
, insulin-like growth factor 1
, insulin-like growth factor I
, insulin-like growth factor IA
, insulin-like growth factor IB
, mechano growth factor
, somatomedin C
, insulin-like growth factor-1
, Insulin-like growth factor I
, class 1 insulin-like growth factor I preproprotein
, insulin growth factor-1
, insulin like growth factor 1
, insulin-like growth factor I (somatomedin C)
, insulin-like growth factor I variant 1
, insulin like growth factor-1
, insulin-like growth factor-I
, insulin-like growth factor 1 (somatomedin C)
, insulin like growth factor 1 S homeolog
, insulin-like growth factor I-A