HER2 Proteine (ERBB2)

Bezeichnung:
V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) Proteine (ERBB2)
Auf www.antikoerper-online.de finden Sie aktuell 96 V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Proteine von 19 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen HER2 Antikörper (1542) und HER2 Kits (48) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 1768 HER2 Produkte verfügbar.
Synonyme:
c-erbB2, c-neu, CD340, Erbb-2, HER-2, HER-2/neu, HER2, mKIAA3023, MLN 19, Neu, NGL, TKR1
alle Proteine anzeigen Gen GeneID UniProt
ERBB2 24337  
ERBB2 2064 P04626
ERBB2 13866 P70424

Weitere Synonyme anzeigen

HER2 Proteine (ERBB2) nach Spezies

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Am meisten referenzierte HER2 Proteine

  1. Human HER2 Protein expressed in Human Cells - ABIN2001860 : Yamamoto, Ikawa, Akiyama, Semba, Nomura, Miyajima, Saito, Toyoshima: Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. in Nature 1986 (PubMed)
    Zeige alle 9 Referenzen für 2001860

  2. Dog (Canine) HER2 Protein expressed in Human Cells - ABIN2008862 : Lai, Lemke: An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. in Neuron 1991 (PubMed)
    Zeige alle 5 Referenzen für 2008862

  3. Cynomolgus HER2 Protein expressed in Human Cells - ABIN2010107 : Gullick, Bottomley, Lofts, Doak, Mulvey, Newman, Crumpton, Sternberg, Campbell: Three dimensional structure of the transmembrane region of the proto-oncogenic and oncogenic forms of the neu protein. in The EMBO journal 1992 (PubMed)
    Zeige alle 5 Referenzen für 2010107

  4. Rat (Rattus) HER2 Protein expressed in Human Cells - ABIN2009129 : Codony-Servat, Albanell, Lopez-Talavera, Arribas, Baselga: Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells. in Cancer research 1999 (PubMed)
    Zeige alle 5 Referenzen für 2009129

  5. Rhesus Monkey HER2 Protein expressed in Human Cells - ABIN2009727 : Tzahar, Yarden: The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands. in Biochimica et biophysica acta 1998 (PubMed)
    Zeige alle 5 Referenzen für 2009727

  6. Human HER2 Protein expressed in HEK-293 Cells - ABIN2181216 : Piechocki, Wu, Jones, Jacob, Gibson, Ethier, Abrams, Yagita, Venuprasad, Wei: Induction of proapoptotic antibodies to triple-negative breast cancer by vaccination with TRAIL death receptor DR5 DNA. in International journal of cancer. Journal international du cancer 2012 (PubMed)
    Zeige alle 4 Referenzen für 2181216

  7. Mouse (Murine) HER2 Protein expressed in HEK-293 Cells - ABIN2181042 : Carraway, Rossi, Komatsu, Price-Schiavi, Huang, Guy, Carvajal, Fregien, Carraway, Carraway: An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling. in The Journal of biological chemistry 1999 (PubMed)
    Zeige alle 3 Referenzen für 2181042

Weitere Proteine zu HER2 Interaktionspartnern

Human V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Interaktionspartner

  1. Data suggest that NDRG1 (zeige NDRG1 Proteine) attenuates oncogenic signaling by inhibiting formation of EGFR (zeige EGFR Proteine)/HER2 and HER2/HER3 (zeige ERBB3 Proteine) heterodimers and by down-regulating EGFR (zeige EGFR Proteine) via a mechanism involving its degradation. (NDRG1 (zeige NDRG1 Proteine) = N-myc downstream regulated gene 1 protein (zeige NDRG1 Proteine); EGFR (zeige EGFR Proteine) = epidermal growth factor receptor (zeige EGFR Proteine); HER = human epidermal growth factor receptor (zeige EGFR Proteine)) [REVIEW]

  2. Elevated levels of sHER2 are associated with worse survival, irrespective of the HER2 status of the tumor, but do not provide additional prognostic information in patients with known circulating tumor cell status.

  3. Report concordance between immunohistochemistry and fluorescence I situ hybridization for HER2 on tissue microarray sections.

  4. Simultaneous suppression of ErbB (zeige EGFR Proteine) kinases and androgen signaling by Celecoxib represents a novel strategy to interrupt the vicious cycle of AR/ErbB (zeige EGFR Proteine) cross-talk with the primary purpose of undermining their resilient signaling in prostate cancer progression.

  5. An interdisciplinary group of German experts has taken on the challenges of HER2 testing in gastric cancer as an opportunity to address essential aspects and questions on the practical use of HER2 testing in this indication from the perspective of pathologists and therapists.

  6. in HER2-overexpressing D492 cells, EGFR (zeige EGFR Proteine) can behave as a tumor suppressor, by pushing the cells towards epithelial differentiation

  7. an important role for MUCL1 (zeige SBEM Proteine) in the proliferation of breast cancer cells

  8. Our study suggests that HER2 overexpression or amplification is a poor prognostic factor in lung adenocarcinoma, although the frequency of such events is low.

  9. High serum HER2 extracellular domain (ECD (zeige SHFM1 Proteine)) had a negative impact on overall survival in patients with gastric cancer. Serum HER2 ECD (zeige SHFM1 Proteine) could be a highly specific surrogate biomarker for tissue HER2 status in gastric cancer.

  10. CRISPR-mediated targeting of HER2 inhibits breast cancer cell proliferation through a dominant negative mutation.

Mouse (Murine) V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Interaktionspartner

  1. Combined targeting of TGF-beta (zeige TGFB1 Proteine), EGFR (zeige EGFR Proteine) and HER2 signaling suppresses lymphangiogenesis and metastasis in a pancreatic ductal adenocarcinoma model.

  2. The conjugation of benzylguanine-modified auristatin F to EGFR (zeige EGFR Proteine)-specific 425(scFv)-SNAP and HER2-specific alphaHER2(scFv)-SNAP resulted in two potent recombinant antibody-drug conjugates that specifically killed breast cancer cell lines by inducing apoptosis when applied at nanomolar concentrations.

  3. ErbB2 is required for neonatal cardiomyocyte proliferation. ErbB2 conditional knockout heart exhibited an upregulation of negative cell cycle regulators.

  4. Despite previous evidence suggesting that ErbB (zeige EGFR Proteine) receptors can bind and activate IRSs, our findings indicate that ErbB2 does not cooperate with the IRS (zeige IARS Proteine) pathway in mouse breast cancer model.

  5. It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis

  6. Study showed that suppression of STAT3 (zeige STAT3 Proteine), STAT5 (zeige STAT5A Proteine), and STAT6 (zeige STAT6 Proteine) and overexpression of the proapoptotic factor STAT1 (zeige STAT1 Proteine), which provides p53 (zeige TP53 Proteine)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 tyrosine kinase receptor (zeige KDR Proteine) overexpression promotes neuronal survival through activation of STAT (zeige STAT1 Proteine)-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1 (zeige STAT1 Proteine)

  7. that myocardial ErbB2 and beta-adrenergic receptors signalling are linked in a feedback loop with beta-adrenergic receptors activation leading to increased ErbB2 expression and activity

  8. Metformin inhibits breast tumor angiogenesis and suggest role of HIF-1alpha (zeige HIF1A Proteine)-VEGF (zeige VEGFA Proteine) signaling axis in mediating HER2-induced tumor angiogenesis.

  9. In trastuzumab-doxorubicin combination therapy in a murine model of HER2+ breast cancer.

  10. Data indicate that Sonic hedgehog (Shh (zeige SHH Proteine)) stimulate branching morphogenesis (BrM (zeige SMARCA2 Proteine)) and induced synthesis of mRNAs for Ptch1 (zeige PTCH1 Proteine) protein, epidermal growth factor (EGF (zeige EGF Proteine)) and receptors of the ErbB (zeige EGFR Proteine) receptors ErbB1 (zeige EGFR Proteine), ErbB2 and ErbB3 (zeige ERBB3 Proteine).

HER2 (ERBB2) Protein Überblick

Protein Überblick

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Alternative names and synonyms associated with HER2 (ERBB2)

  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (ERBB2)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene 2 (Erbb2)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2)
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (Erbb2)
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2)
  • c-erbB2 Protein
  • c-neu Protein
  • CD340 Protein
  • Erbb-2 Protein
  • HER-2 Protein
  • HER-2/neu Protein
  • HER2 Protein
  • mKIAA3023 Protein
  • MLN 19 Protein
  • Neu Protein
  • NGL Protein
  • TKR1 Protein

Bezeichner auf Proteinebene für ERBB2

receptor tyrosine-protein kinase erbB-2 , Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog) , C-erbB-2 , NEU proto-oncogene , epidermal growth factor receptor-related protein , p185erbB2 , p185neu , proto-oncogene NEU , proto-oncogene c-ErbB-2 , v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog , c-erb B2/neu protein , herstatin , metastatic lymph node gene 19 protein , neuro/glioblastoma derived oncogene homolog , neuroblastoma/glioblastoma derived oncogene homolog , proto-oncogene Neu , tyrosine kinase-type cell surface receptor HER2 , Neu oncogene , avian erythroblastosis oncogene B 2 , c-erbB-2 , erbB-2

GENE ID SPEZIES
426130 Gallus gallus
24337 Rattus norvegicus
2064 Homo sapiens
13866 Mus musculus
403883 Canis lupus familiaris
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