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Human HER2 ELISA Kit für Sandwich ELISA - ABIN921095
Tao, Suhua, Juanjuan, Zongzhi, Juan, Dandan: In vitro study on human cytomegalovirus affecting early pregnancy villous EVT's invasion function. in Virology journal 2011
Human HER2 ELISA Kit für Sandwich ELISA - ABIN625296
Laidi, Bouziane, Lakhdar, Khabouze, Rhrab, Zaoui: Salivary expression of soluble HER2 in breast cancer patients with positive and negative HER2 status. in OncoTargets and therapy 2014
MiR (zeige MLXIP ELISA Kits)-193a-5p/ERBB2 have roles in response to chemoradiation therapy of esophageal squamous cell carcinoma
Trastuzumab treatment improves patients' survival regardless of HR status and should be offered to all HER2+ patients.
We aimed to investigate the prevalence, clinicopathologic characteristics, and functional relevance of novel HER2 mutations in breast cancer
the optimal discrimination cut-off for each cytokine: sVEGFR-1 (2124.5pg/mL), IL-6 (zeige IL6 ELISA Kits) (40.2pg/mL), VEGF-A (zeige VEGFA ELISA Kits) (1060.1pg/mL), Angiopoeintin-2 (913.7pg/mL), uPA (zeige PRAP1 ELISA Kits) (248.1pg/mL), sHER-2/neu (5010pg/mL) and PLGF (zeige PGF ELISA Kits) (93.4pg/mL). For the very first time, a novel cytokine profile associated with cancer metastasis to the paratracheal lymph nodes were reported.
data show that ErbB2 and Akt are important for CNC migration and implicate other ErbB receptors and Akt-independent signaling pathways. Our findings provide the first example of a functional interaction between the extracellular domain of a type II classical cadherin and growth factor receptors
The 12.5% overall overexpression/amplification or HER-2 in gastric and gastroesophageal junction adenocarcinomas is in concordance with previous reports. No correlation was found between tumor stage and HER2 overexpression/amplification. Determination of HER2 in limited tissue samples benefits from combinational immunohistochemistry and dual in situ hybridization testing.
Erb (zeige ESR2 ELISA Kits)-b2 receptor tyrosine kinase (zeige RET ELISA Kits) 2 (zeige TYK2 ELISA Kits) gene (ERBB2/HER2) copy number gain was identified as a putative resistance mechanism to afatinib.
Our findings underline the survival benefit achieved by eribulin used according to European Union label in the overall metastatic breast cancer population and in various subgroups of interest, including patients with HER2-negative and triple-negative disease
Overall PIK3CA (zeige PIK3CA ELISA Kits) mutant/HER2+ tumours had significantly lower pCR rates compared with wild-type tumours, however mainly confined to the HR+/PIK3CA (zeige PIK3CA ELISA Kits) mutant population. No definite conclusions can be drawn regarding survival
Results suggest that our approach could provide a platform to develop nano-diagnostic agents or nano-therapeutic agents for early detection and treatment of HER-2-positive cancers.
YAP (zeige YAP1 ELISA Kits) accumulated in nuclei of mammary glands in ErbB2/EGFR (zeige EGFR ELISA Kits)-transgenic mice, suggesting that EGFR (zeige EGFR ELISA Kits) signaling affects YAP (zeige YAP1 ELISA Kits) in vivo similar to cell culture. ErbB2/EGFR (zeige EGFR ELISA Kits)-transgenic mice develop mammary tumors in 7-8 months, but surprisingly, MaSCs from these mice did not form tumors when transplanted into host mice.
Results indicate the importance of the LDL receptor (LDLR (zeige LDLR ELISA Kits)) in the growth of triple-negative and HER2-overexpressing breast cancers in the setting of elevated circulating LDL cholesterol (LDL-C).
immunocompetent mouse models of HER2/ErbB2-driven breast cancer, CD73 expression by tumor cells and host cells significantly suppressed immune-mediated responses mediated by anti-ErbB2 mAb.
We further demonstrate that loss of one allele of PTEN is sufficient to shift isoform dependency from p110alpha (zeige PIK3CA ELISA Kits) to p110beta in vivo. These results provide insight into the molecular mechanism by which ErbB2-positive breast cancer escapes p110alpha (zeige PIK3CA ELISA Kits) inhibition.
sought to further echocardiographically characterize the ErbB2(tg) mouse line as a model of hypertrophic obstructive cardiomyopathy
investigations revealed that NUMB (zeige NUMB ELISA Kits) and NUMBL (zeige NUMBL ELISA Kits) interacted with small GTPase (zeige RACGAP1 ELISA Kits) Rab7 (zeige RAB7A ELISA Kits) to transition ERBB2 from early to late endosome for degradation.
Combined targeting of TGF-beta (zeige TGFB1 ELISA Kits), EGFR (zeige EGFR ELISA Kits) and HER2 signaling suppresses lymphangiogenesis and metastasis in a pancreatic ductal adenocarcinoma model.
The conjugation of benzylguanine-modified auristatin F to EGFR (zeige EGFR ELISA Kits)-specific 425(scFv)-SNAP and HER2-specific alphaHER2(scFv)-SNAP resulted in two potent recombinant antibody-drug conjugates that specifically killed breast cancer cell lines by inducing apoptosis when applied at nanomolar concentrations.
ErbB2 is required for neonatal cardiomyocyte proliferation. ErbB2 conditional knockout heart exhibited an upregulation of negative cell cycle regulators.
Despite previous evidence suggesting that ErbB (zeige EGFR ELISA Kits) receptors can bind and activate IRSs, our findings indicate that ErbB2 does not cooperate with the IRS (zeige IARS ELISA Kits) pathway in mouse breast cancer model.
Newly synthesized N-cadherin (zeige CDH2 ELISA Kits) molecules move from the lateral to the basal surface of cardiomyocytes during trabeculation. This localization requires Erbb2 signaling.
these results suggest that Nrg1 (zeige NRG1 ELISA Kits) is not the primary effector of trabeculation and/or that other EGF (zeige EGF ELISA Kits)-like ligand(s) activates the ErbB2/ErbB4 (zeige ERBB4 ELISA Kits) pathway, either through functioning as the primary ligand or acting in a redundant manner. Overall, our work provides an example of cross-species differences in EGF (zeige EGF ELISA Kits) family member requirements for an evolutionary conserved process.
Embryos homozygous for a GBT insertion within neuregulin 2a (nrg2a) revealed a novel requirement for a Neuregulin 2a (Nrg2a)-ErbB2/3-AKT (zeige AKT1 ELISA Kits) signaling pathway governing the organization of a subset of epidermal cells during median fin fold morphogenesis.
A direct link was found between Erbb2 activity and remodeling of myofibrils.
Study shows that, in addition to its role in cardiomyocyte proliferation, ErbB2 is also required for regulating cardiomyocyte migration (delamination) to initiate cardiac trabeculation.
erbb3 (zeige ERBB3 ELISA Kits) and erbb2 are essential for schwann cell migration and myelination in zebrafish.
NRG1 (zeige NRG1 ELISA Kits) and PI3K functionally interact with ErbB2 and ErbB3 (zeige ERBB3 ELISA Kits) during regeneration
Results indicated that most periocular squamous cell carcinomas of horses expressed epidermal growth factor receptor (EGFR (zeige EGFR ELISA Kits)) and human epidermal growth factor receptor (zeige EGFR ELISA Kits) 2 (HER2).[HER2]
Widespread expression of ErbB2 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization, with higher levels in grey matter compared to white matter.
We have isolated the cDNA encoding the rhesus monkey homolog of human Her2/neu (RhErbB2) to construct DNA plasmids and adenoviral vectors for the development of a cancer vaccine against this protein.
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
c-erb B2/neu protein
, metastatic lymph node gene 19 protein
, neuro/glioblastoma derived oncogene homolog
, neuroblastoma/glioblastoma derived oncogene homolog
, proto-oncogene Neu
, proto-oncogene c-ErbB-2
, receptor tyrosine-protein kinase erbB-2
, tyrosine kinase-type cell surface receptor HER2
, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
, Neu oncogene
, avian erythroblastosis oncogene B 2
, proto-oncogene NEU
, Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog)
, NEU proto-oncogene
, epidermal growth factor receptor-related protein
, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
, epidermal growth factor receptor type 2