anti-HER2 (ERBB2) Antikörper

Bezeichnung:
anti-V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) Antikörper (ERBB2)
Auf www.antikoerper-online.de finden Sie aktuell 1583 V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Antikörper von 44 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen HER2 Proteine (104) und HER2 Kits (53) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 1824 HER2 Produkte verfügbar.
Synonyme:
c-erbB2, c-neu, CD340, Erbb-2, HER-2, HER-2/neu, HER2, mKIAA3023, MLN 19, Neu, NGL, TKR1
Alle Antikörper anzeigen Gen GeneID UniProt
ERBB2 24337  
ERBB2 2064 P04626
ERBB2 13866 P70424

Alle Spezies anzeigen

Weitere Synonyme anzeigen

Alle verfügbaren anti-HER2 Antikörper

Sie gelangen zu unserer vorgefilterten Suche.

Am meisten referenzierte anti-HER2 Antikörper

  1. Human Monoclonal HER2 Primary Antibody für IHC (p) - ABIN1688892 : Savci-Heijink, Halfwerk, Hooijer, Horlings, Wesseling, van de Vijver: Retrospective analysis of metastatic behaviour of breast cancer subtypes. in Breast cancer research and treatment 2015 (PubMed)
    Zeige alle 50 Referenzen für 1688892

  2. Human Monoclonal HER2 Primary Antibody für IF, IHC (p) - ABIN180514 : DiGiovanna, Stern: Activation state-specific monoclonal antibody detects tyrosine phosphorylated p185neu/erbB-2 in a subset of human breast tumors overexpressing this receptor. in Cancer research 1995 (PubMed)
    Zeige alle 11 Referenzen für 180514

  3. Human Polyclonal HER2 Primary Antibody für IHC (p), WB - ABIN391947 : Ehsani, Low, Wallace, Wu: Characterization of a new allele of the human ERBB2 gene by allele-specific competition hybridization. in Genomics 1993 (PubMed)
    Zeige alle 4 Referenzen für 391947

  4. Human Polyclonal HER2 Primary Antibody für FACS, IF - ABIN391948 : Yamamoto, Ikawa, Akiyama, Semba, Nomura, Miyajima, Saito, Toyoshima: Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. in Nature 1986 (PubMed)
    Zeige alle 4 Referenzen für 391948

  5. Human Polyclonal HER2 Primary Antibody für FACS, IHC (p) - ABIN391945 : Coussens, Yang-Feng, Liao, Chen, Gray, McGrath, Seeburg, Libermann, Schlessinger, Francke: Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. in Science (New York, N.Y.) 1985 (PubMed)
    Zeige alle 4 Referenzen für 391945

  6. Human Polyclonal HER2 Primary Antibody für IF, ELISA - ABIN1532607 : King, Kraus, Aaronson: Amplification of a novel v-erbB-related gene in a human mammary carcinoma. in Science (New York, N.Y.) 1985 (PubMed)
    Zeige alle 3 Referenzen für 1532607

  7. Human Polyclonal HER2 Primary Antibody für IF, ELISA - ABIN1531590 : Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006 (PubMed)
    Zeige alle 3 Referenzen für 1531590

  8. Human Polyclonal HER2 Primary Antibody für IHC (fro), IHC (p) - ABIN115291 : Schechter, Hung, Vaidyanathan, Weinberg, Yang-Feng, Francke, Ullrich, Coussens: The neu gene: an erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor. in Science (New York, N.Y.) 1985 (PubMed)
    Zeige alle 3 Referenzen für 115291

Weitere Antikörper gegen HER2 Interaktionspartner

Human V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Interaktionspartner

  1. Results indicate a mechanism of action for neuromedin U (NmU (zeige NMU Antikörper)) in HER2-overexpressing breast cancer that enhances resistance to HER2-targeted drugs through conferring cancer stem cell (CSC) characteristics and expansion of the CSC phenotype.

  2. the estrogen- (ER), progesterone- (PgR (zeige PGR Antikörper)) and HER2/neu receptor status of the primary tumor with brain metastases in a series of 24 consecutive breast cancer patients, is reported.

  3. tumor-promoting role for CCL2 acting through CCR2 on the tumor microenvironment

  4. We observed correlations between time to tumor relapse and the magnitude of changes of proliferation, luminal B, or HER2-E signatures in metastatic versus primary disease. Although the intrinsic subtype was largely maintained during metastatic progression, luminal/HER2-negative tumors acquired a luminal B or HER2-E profile during metastatic progression, likely reflecting tumor evolution or acquisition of estrogen independ

  5. Results indicate that p110alpha (zeige PIK3CA Antikörper) primarily mediates PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) signaling in HER2+ PTEN (zeige PTEN Antikörper) deficient breast tumors whereas p110beta conditionally mediates HER2/PI3K (zeige PIK3CA Antikörper) signaling in the absence of p110alpha (zeige PIK3CA Antikörper).

  6. Data indicate that co-inhibition of FGFR1 (zeige FGFR1 Antikörper) and HER2 or PDGFRalpha led to enhanced drug responses.

  7. Her-2-positive metastatic breast cancers, PTEN (zeige PTEN Antikörper) positivity was significantly associated with progressive disease, but not with PFS or OS

  8. This study demonstrated that discordance between the HER2 expression of circulating tumor cells (CTCs) and that of the primary tumor frequently occurs in early breast cancer. Future follow-up evaluation will assess whether this discrepancy may contribute to trastuzumab resistance.

  9. Increased ezrin (zeige EZR Antikörper) and HER2 expression in patients with salivary gland carcinomas represents a high-grade histopathological subtype.

  10. our findings identified a subset of EGFR (zeige EGFR Antikörper) and HER2 exon 20 insertion mutations that are sensitive to existing covalent quinazoline-based EGFR (zeige EGFR Antikörper)/HER2 inhibitors, with implications for current clinical treatment and next-generation small-molecule inhibitors.

Mouse (Murine) V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Interaktionspartner

  1. investigations revealed that NUMB (zeige NUMB Antikörper) and NUMBL (zeige NUMBL Antikörper) interacted with small GTPase (zeige RACGAP1 Antikörper) Rab7 (zeige RAB7A Antikörper) to transition ERBB2 from early to late endosome for degradation.

  2. Combined targeting of TGF-beta (zeige TGFB1 Antikörper), EGFR (zeige EGFR Antikörper) and HER2 signaling suppresses lymphangiogenesis and metastasis in a pancreatic ductal adenocarcinoma model.

  3. The conjugation of benzylguanine-modified auristatin F to EGFR (zeige EGFR Antikörper)-specific 425(scFv)-SNAP and HER2-specific alphaHER2(scFv)-SNAP resulted in two potent recombinant antibody-drug conjugates that specifically killed breast cancer cell lines by inducing apoptosis when applied at nanomolar concentrations.

  4. ErbB2 is required for neonatal cardiomyocyte proliferation. ErbB2 conditional knockout heart exhibited an upregulation of negative cell cycle regulators.

  5. Despite previous evidence suggesting that ErbB (zeige EGFR Antikörper) receptors can bind and activate IRSs, our findings indicate that ErbB2 does not cooperate with the IRS (zeige IARS Antikörper) pathway in mouse breast cancer model.

  6. It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis

  7. Study showed that suppression of STAT3 (zeige STAT3 Antikörper), STAT5 (zeige STAT5A Antikörper), and STAT6 (zeige STAT6 Antikörper) and overexpression of the proapoptotic factor STAT1 (zeige STAT1 Antikörper), which provides p53 (zeige TP53 Antikörper)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 tyrosine kinase receptor (zeige KDR Antikörper) overexpression promotes neuronal survival through activation of STAT (zeige STAT1 Antikörper)-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1 (zeige STAT1 Antikörper)

  8. that myocardial ErbB2 and beta-adrenergic receptors signalling are linked in a feedback loop with beta-adrenergic receptors activation leading to increased ErbB2 expression and activity

  9. Metformin inhibits breast tumor angiogenesis and suggest role of HIF-1alpha (zeige HIF1A Antikörper)-VEGF (zeige VEGFA Antikörper) signaling axis in mediating HER2-induced tumor angiogenesis.

  10. In trastuzumab-doxorubicin combination therapy in a murine model of HER2+ breast cancer.

HER2 (ERBB2) Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Alternative names and synonyms associated with HER2 (ERBB2)

  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (ERBB2) Antikörper
  • v-erb-b2 avian erythroblastic leukemia viral oncogene 2 (Erbb2) Antikörper
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2) Antikörper
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (Erbb2) Antikörper
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2) Antikörper
  • c-erbB2 Antikörper
  • c-neu Antikörper
  • CD340 Antikörper
  • Erbb-2 Antikörper
  • HER-2 Antikörper
  • HER-2/neu Antikörper
  • HER2 Antikörper
  • mKIAA3023 Antikörper
  • MLN 19 Antikörper
  • Neu Antikörper
  • NGL Antikörper
  • TKR1 Antikörper

Bezeichner auf Proteinebene für ERBB2

receptor tyrosine-protein kinase erbB-2 , Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog) , C-erbB-2 , NEU proto-oncogene , epidermal growth factor receptor-related protein , p185erbB2 , p185neu , proto-oncogene NEU , proto-oncogene c-ErbB-2 , v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog , c-erb B2/neu protein , herstatin , metastatic lymph node gene 19 protein , neuro/glioblastoma derived oncogene homolog , neuroblastoma/glioblastoma derived oncogene homolog , proto-oncogene Neu , tyrosine kinase-type cell surface receptor HER2 , Neu oncogene , avian erythroblastosis oncogene B 2 , c-erbB-2 , erbB-2

GENE ID SPEZIES
426130 Gallus gallus
24337 Rattus norvegicus
2064 Homo sapiens
13866 Mus musculus
403883 Canis lupus familiaris
Ausgewählte Anbieter für anti-HER2 (ERBB2) Antikörper
Haben Sie etwas anderes gesucht?