anti-GRB2 (GRB2) Antikörper

Bezeichnung:
anti-Growth Factor Receptor-Bound Protein 2 Antikörper (GRB2)
Auf www.antikoerper-online.de finden Sie aktuell 160 Growth Factor Receptor-Bound Protein 2 (GRB2) Antikörper von 24 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen GRB2 Kits (29) und GRB2 Proteine (23) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 221 GRB2 Produkte verfügbar.
Synonyme:
AA408164, ASH, EGFRBP-GRB2, grb2, Grb3-3, MST084, MSTP084, NCKAP2, wu:fb18e12, wu:fb34e06, zgc:73077

Meistgesuchte Reaktivitäten zu anti-GRB2 (GRB2) Antikörper

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anti-Mouse (Murine) GRB2 Antikörper:

anti-Rat (Rattus) GRB2 Antikörper:

anti-Human GRB2 Antikörper:

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Am meisten referenzierte anti-GRB2 Antikörper

  1. Human Monoclonal GRB2 Primary Antibody für WB - ABIN2853618 : Rozakis-Adcock, Fernley, Wade, Pawson, Bowtell: The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. in Nature 1993 (PubMed)
    Zeige alle 6 Referenzen für 2853618

  2. Chicken Monoclonal GRB2 Primary Antibody für BI, IP - ABIN967754 : Elowe, Holland, Kulkarni, Pawson: Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction. in Molecular and cellular biology 2001 (PubMed)
    Zeige alle 5 Referenzen für 967754

  3. Human Polyclonal GRB2 Primary Antibody für IHC (p), WB - ABIN390236 : Kondo, Hirayama, Sugito, Shono, Tanaka, Kitamura: Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation. in The Journal of biological chemistry 2008 (PubMed)
    Zeige alle 3 Referenzen für 390236

  4. Human Polyclonal GRB2 Primary Antibody für EIA, IHC (p) - ABIN358795 : Morimatsu, Takagi, Ota, Iwamoto, Yanagida, Sako: Multiple-state reactions between the epidermal growth factor receptor and Grb2 as observed by using single-molecule analysis. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)
    Zeige alle 3 Referenzen für 358795

  5. Human Polyclonal GRB2 Primary Antibody für ELISA, WB - ABIN1534949 : Fath, Schweighoffer, Rey, Multon, Boiziau, Duchesne, Tocqué: Cloning of a Grb2 isoform with apoptotic properties. in Science (New York, N.Y.) 1994 (PubMed)
    Zeige alle 2 Referenzen für 1534949

  6. Human Polyclonal GRB2 Primary Antibody für IHC, ELISA - ABIN1532105 : Nishida, Yoshida, Itoh, Fukada, Ohtani, Shirogane, Atsumi, Takahashi-Tezuka, Ishihara, Hibi, Hirano: Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. in Blood 1999 (PubMed)
    Zeige alle 2 Referenzen für 1532105

  7. Human Polyclonal GRB2 Primary Antibody für ELISA, IHC - ABIN257708 : Lowenstein, Daly, Batzer, Li, Margolis, Lammers, Ullrich, Skolnik, Bar-Sagi, Schlessinger: The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. in Cell 1992 (PubMed)

Weitere Antikörper gegen GRB2 Interaktionspartner

Mouse (Murine) Growth Factor Receptor-Bound Protein 2 (GRB2) Interaktionspartner

  1. Two Dtna (zeige DTNA Antikörper) interactors, alpha-catulin (zeige CTNNAL1 Antikörper) (phosphorylation independent) and Grb2 (phosphorylation dependent) are localized to neuromuscular junctions in vivo, and are required for proper organization of neurotransmitter receptors on myotubes.

  2. Grb2-deficient T cells show defects in T cell development, increased Th1 (zeige HAND1 Antikörper) and Th17 cell differentiation capacities, and impaired proliferation after activation by dendritic cells, which likely reduce the clinical symptoms of EAE.

  3. provide evidence that CD28 (zeige CD28 Antikörper) and the TCR complex regulate NF-kappaB (zeige NFKB1 Antikörper) via different signaling modules of GRB-2/VAV1 (zeige VAV1 Antikörper) and LAT (zeige LAT Antikörper)/ADAP (zeige APP Antikörper) pathways respectively.

  4. GRB2 physically links cyt (zeige CYGB Antikörper)-PTPe (zeige PTPRE Antikörper) with Src (zeige SRC Antikörper) and enables cyt (zeige CYGB Antikörper)-PTPe (zeige PTPRE Antikörper) to activate Src (zeige SRC Antikörper) downstream of activated integrins in osteoclast-like cells.

  5. SUMOylation of Grb2 enhances the ERK (zeige EPHB2 Antikörper) activity by increasing its binding with Sos1 (zeige SOS1 Antikörper).

  6. Data indicate that growth factor receptor (zeige RYK Antikörper) protein binding protein 2 (Grb2) is upregulated and regulated by Forkhead Box D3 (Foxd3 (zeige FOXD3 Antikörper)), and pregulated Grb2 interacts with huntingtin (Htt (zeige HTT Antikörper)).

  7. Grb2 contributes to immunoreceptor tyrosine-based activation motif signaling in platelets during hemostasis and thrombosis.

  8. Findings indicate Grb2 as a new FAK (zeige PTK2 Antikörper) activator and in coordinating PTPalpha (zeige PTPRA Antikörper) tyrosine phosphorylation to enable downstream integrin signaling and migration.

  9. Grb2 is not required for the establishment of the glomerular filtration barrier in vivo.

  10. Study shows that the ability of Sos1/Grb2 to appropriately regulate pluripotency and differentiation factors and to initiate primitive endoderm development requires collective binding of multiple Sos1/Grb2 domains to their protein and phospholipid ligands.

Human Growth Factor Receptor-Bound Protein 2 (GRB2) Interaktionspartner

  1. ACTB (zeige ACTB Antikörper), CDKN1B (zeige CDKN1B Antikörper), GAPDH (zeige GAPDH Antikörper), GRB2, RHOA (zeige RHOA Antikörper) and SDCBP (zeige SDCBP Antikörper) are potent reference genes in neuroendocrine tumors of the lung.

  2. We show that the decrease in PI(4,5)P2 level under non-stimulated conditions inhibits PTEN (zeige PTEN Antikörper) activity leading to the aberrant activation of the oncoprotein Akt (zeige AKT1 Antikörper). As well as defining a novel mechanism of Akt (zeige AKT1 Antikörper) phosphorylation with important therapeutic consequences, we also demonstrate that differential expression levels of FGFR2 (zeige FGFR2 Antikörper), Plc11 and Grb2 correlate with patient survival

  3. Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2), Grb2-related adaptor downstream of Shc (zeige SHC1 Antikörper) (Gads (zeige GRAP2 Antikörper)), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src (zeige SRC Antikörper) homology 2 (SH2) domains, leading to downstream signaling to distinct immune pathways. These three adaptor proteins bind to the same site on CD28 (zeige CD28 Antikörper) with variable affinity

  4. investigated the target and mechanism of miR-411-5p in breast cancer using mimic and inhibitor, and demonstrated the involvement of GRB2 and Ras activation

  5. The study presents EPR (zeige EREG Antikörper) spectroscopic analysis of the binding of the wild-type and mutant Grb2 SH2 domains to the CSpYVNVQC peptide variant. These data confirm that the binding specificity of SH2 domains, even that of Grb2, results from multiple factors and does not depend merely on the nature of one particular residue.

  6. TGF-beta2 (zeige TGFB2 Antikörper) induces Grb2 to recruit PI3-K (zeige PIK3CA Antikörper) to TGF-RII that activates JNK (zeige MAPK8 Antikörper)/AP-1 (zeige FOSB Antikörper)-signaling and augments invasiveness of Theileria-transformed macrophages.

  7. Genetic variation near GRB2 on chromosome 17q25.1 is associated with sight-threatening diabetic retinopathy.

  8. Only monomeric Grb2 is capable of upregulating MAP kinase (zeige MAPK1 Antikörper) signalling. The dimeric state is inhibitory to this process. The self-association/dissociation of Grb2 represents a switch that regulates MAP kinase (zeige MAPK1 Antikörper) activity and hence controls cancer progression.

  9. The immunoglobulin tail tyrosine motif in the cytoplasmic segments of membrane-bound IgGs acts as the principle signal amplifier by incorporating a Grb2-Btk (zeige BTK Antikörper) signaling.

  10. findings show that regions outside of the consensus PxxPxR sites drive the high affinity association of GRB2 with SH3 domain (zeige ITSN1 Antikörper) ligands

Pig (Porcine) Growth Factor Receptor-Bound Protein 2 (GRB2) Interaktionspartner

  1. in VSMCs exposed to hyperglycemia, IGF-I (zeige IGF1 Antikörper) stimulation of Shc (zeige SHC1 Antikörper) facilitates the transfer of Grb2 to p85 (zeige ARHGEF7 Antikörper) resulting in enhanced PI3K activation and AKT (zeige AKT1 Antikörper) phosphorylation leading to enhanced cell proliferation and migration

GRB2 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with GRB2

  • growth factor receptor-bound protein 2 (GRB2) Antikörper
  • Growth factor receptor-bound protein 2 (grb2) Antikörper
  • growth factor receptor-bound protein 2 (grb2) Antikörper
  • growth factor receptor bound protein 2 (Grb2) Antikörper
  • growth factor receptor-bound protein 2 (LOC100342500) Antikörper
  • growth factor receptor-bound protein 2 (Grb2) Antikörper
  • growth factor receptor-bound protein 2b (grb2b) Antikörper
  • AA408164 Antikörper
  • ASH Antikörper
  • EGFRBP-GRB2 Antikörper
  • grb2 Antikörper
  • Grb3-3 Antikörper
  • MST084 Antikörper
  • MSTP084 Antikörper
  • NCKAP2 Antikörper
  • wu:fb18e12 Antikörper
  • wu:fb34e06 Antikörper
  • zgc:73077 Antikörper

Bezeichner auf Proteinebene für GRB2

growth factor receptor-bound protein 2 , Growth factor receptor-bound protein 2 , SH2/SH3 adapter GRB2 , adapter protein GRB2 , protein Ash , HT027 , abundant SRC homology , epidermal growth factor receptor-binding protein GRB2 , growth factor receptor-bound protein 3 , growth factor receptor bound protein 2 , fb18e12

GENE ID SPEZIES
737245 Pan troglodytes
100306767 Salmo salar
100528114 Ictalurus punctatus
14784 Mus musculus
81504 Rattus norvegicus
2885 Homo sapiens
483312 Canis lupus familiaris
535298 Bos taurus
100342500 Oryctolagus cuniculus
100715453 Cavia porcellus
100192436 Sus scrofa
386572 Gallus gallus
101109893 Ovis aries
100173972 Pongo abelii
406308 Danio rerio
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