FLT3 (FLT3) ELISA Kits

Bezeichnung:
Fms-Related tyrosine Kinase 3 ELISA Kits (FLT3)
Auf www.antikoerper-online.de finden Sie aktuell 40 Fms-Related tyrosine Kinase 3 (FLT3) ELISA Kits von 14 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen FLT3 Antikörper (366) und FLT3 Proteine (28) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 445 FLT3 Produkte verfügbar.
Synonyme:
B230315G04, CD135, FLK-2, FLK2, Flt-3, FLT3, Ly72, STK1, wmfl

Weitere ELISA Kits für FLT3 Interaktionspartner

Mouse (Murine) Fms-Related tyrosine Kinase 3 (FLT3) Interaktionspartner

  1. the Hoxa9 (zeige HOXA9 ELISA Kits)- and Meis1 (zeige MEIS1 ELISA Kits)-associated upregulation of Flt3 is a passive event with regard to leukemia development in mice and with limited relevance to the AML (zeige RUNX1 ELISA Kits) pathology.

  2. lineage-specific STAT5 (zeige STAT5A ELISA Kits) activation in hematopoietic progenitor cells predicts the FLT3(+)-mediated leukemic phenotype in mice

  3. DOCK2 (zeige DOCK2 ELISA Kits) is a potential therapeutic target for novel AML (zeige RUNX1 ELISA Kits) treatments, as this protein regulates the survival of leukemia cells with elevated FLT3 activity and sensitizes FLT3/ITD leukemic cells to conventional antileukemic agents.

  4. Used a genetic model to determine whether miR (zeige MLXIP ELISA Kits)-155 influences the development of FLT3-ITD-induced myeloproliferative disease. miR (zeige MLXIP ELISA Kits)-155 promotes FLT3-ITD-induced myeloid expansion in the bone marrow, spleen, and peripheral blood. Mechanistically, miR (zeige MLXIP ELISA Kits)-155 increases proliferation of the hematopoietic stem and progenitor cell compartments by reducing the growth-inhibitory effects of the interferon (zeige IFNA ELISA Kits) response.

  5. Overexpression of Abl (zeige ABL1 ELISA Kits)-related gene tyrosine kinase (zeige TYRO3 ELISA Kits) ABL2 in pro-B cell line Ba/F3 cells expressing an oncogenic mutant of FLT3 (FLT3-ITD) resulted in partial inhibition of FLT3-ITD-dependent cell proliferation.

  6. Sorafenib-resistant leukemia cells with a FLT3/ITD mutation are sensitive to glycolytic inhibitors.

  7. FLT3-ITD is capable of inhibiting FLT3-ITD+ cell proliferation through the p21/Pbx1 (zeige PBX1 ELISA Kits) axis

  8. Data indicate that most Fms-like tyrosine kinase-3 (FLT3) tyrosine kinase (zeige TYRO3 ELISA Kits) inhibitors (TKI) effectively target wild-type FLT3 signaling.

  9. DNMT3A (zeige DNMT3A ELISA Kits) haploinsufficiency results in reversible epigenetic alterations that transform FLT3(ITD)-mutant myeloproliferative neoplasm into AML (zeige RUNX1 ELISA Kits).

  10. murine Fms-like tyrosine kinase 3 (Flt3) ligand (zeige FLT3LG ELISA Kits) was used to generate conventional dendritic cells (FL-cDCs) and plasmacytoid DCs (FL-pDCs) and further evaluated their immunological responses to bacillus Calmette-Guerin (BCG (zeige SLC11A1 ELISA Kits)) infection in vitro.

Human Fms-Related tyrosine Kinase 3 (FLT3) Interaktionspartner

  1. Collectively, we have developed a novel targeted therapeutic strategy, using FLT3L (zeige FLT3LG ELISA Kits)-guided miR (zeige MLXIP ELISA Kits)-150-based nanoparticles, to treat FLT3-overexpressing AML (zeige RUNX1 ELISA Kits) with high efficacy and minimal side effects.

  2. Y842 is critical for FLT3-mediated RAS/ERK (zeige EPHB2 ELISA Kits) signaling and cellular transformation.

  3. value of FLT3-ITD allelic ratio in AML (zeige RUNX1 ELISA Kits) in risk assessment and evaluating prognosis

  4. DOCK2 (zeige DOCK2 ELISA Kits) is a potential therapeutic target for novel AML (zeige RUNX1 ELISA Kits) treatments, as this protein regulates the survival of leukemia cells with elevated FLT3 activity and sensitizes FLT3/ITD leukemic cells to conventional antileukemic agents.

  5. Gedatolisib significantly extended survival of mice in a sorafenib-resistant acute myeloid leukemia (zeige BCL11A ELISA Kits) (AML (zeige RUNX1 ELISA Kits)) patient-derived xenograft model. Taken together, our data suggest that aberrant activation of the PI3K (zeige PIK3CA ELISA Kits)/mTOR (zeige FRAP1 ELISA Kits) pathway in FLT3-ITD-dependent AML (zeige RUNX1 ELISA Kits) results in resistance to drugs targeting FLT3.

  6. HHEX (zeige HHEX ELISA Kits) could replace RUNX1 (zeige RUNX1 ELISA Kits) in cooperating with FLT3-ITD to induce Acute myeloid leukemia (zeige BCL11A ELISA Kits) (AML (zeige RUNX1 ELISA Kits)).

  7. mutated FLT3-ITD and JAK2 (zeige JAK2 ELISA Kits) augment reactive oxygen species production and homologous recombination, shifting the cellular milieu toward illegitimate recombination.

  8. these data reveal a novel mechanism which regulates acute myeloid leukemia (zeige BCL11A ELISA Kits) cell death by ceramide-dependent mitophagy in response to FLT3-ITD targeting.

  9. MSI2 (zeige MSI2 ELISA Kits) and FLT3 are significantly co-regulated in human AML (zeige RUNX1 ELISA Kits)

  10. Sorafenib-resistant leukemia cells with a FLT3/ITD mutation are sensitive to glycolytic inhibitors.

FLT3 Antigen-Profil

Beschreibung des Gens

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Alternative names and synonyms associated with FLT3

  • fms-related tyrosine kinase 3 (FLT3) Elisa Kit
  • FMS-like tyrosine kinase 3 (Flt3) Elisa Kit
  • fms-related tyrosine kinase 3 (Flt3) Elisa Kit
  • B230315G04 Elisa Kit
  • CD135 Elisa Kit
  • FLK-2 Elisa Kit
  • FLK2 Elisa Kit
  • Flt-3 Elisa Kit
  • FLT3 Elisa Kit
  • Ly72 Elisa Kit
  • STK1 Elisa Kit
  • wmfl Elisa Kit

Bezeichner auf Proteinebene für FLT3

fms-related tyrosine kinase 3 , FL cytokine receptor-like , FL cytokine receptor , fetal liver kinase 2 , receptor-type tyrosine-protein kinase FLT3 , tyrosine-protein kinase FLT3 , tyrosine-protein kinase receptor flk-2 , CD135 antigen , STK-1 , fms-like tyrosine kinase 3 , growth factor receptor tyrosine kinase type III , stem cell tyrosine kinase 1 , FMS-like tyrosine kinase 3

GENE ID SPEZIES
452508 Pan troglodytes
100061780 Equus caballus
100413316 Callithrix jacchus
14255 Mus musculus
2322 Homo sapiens
140635 Rattus norvegicus
486025 Canis lupus familiaris
512700 Bos taurus
100858422 Gallus gallus
100515445 Sus scrofa
100732047 Cavia porcellus
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