anti-FLT3 (FLT3) Antikörper

Bezeichnung:
anti-Fms-Related tyrosine Kinase 3 Antikörper (FLT3)
Auf www.antikoerper-online.de finden Sie aktuell 366 Fms-Related tyrosine Kinase 3 (FLT3) Antikörper von 33 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen FLT3 Kits (40) und FLT3 Proteine (28) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 445 FLT3 Produkte verfügbar.
Synonyme:
B230315G04, CD135, FLK-2, FLK2, Flt-3, FLT3, Ly72, STK1, wmfl

Meistgesuchte Reaktivitäten zu anti-FLT3 (FLT3) Antikörper

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anti-Mouse (Murine) FLT3 Antikörper:

anti-Human FLT3 Antikörper:

anti-Rat (Rattus) FLT3 Antikörper:

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Am meisten referenzierte anti-FLT3 Antikörper

  1. Human Polyclonal FLT3 Primary Antibody für EIA, IHC (p) - ABIN359869 : Seidlits, Reza, Briand, Sereno: Voluntary spatial attention has different effects on voluntary and reflexive saccades. in TheScientificWorldJournal 2003 (PubMed)
    Zeige alle 5 Referenzen für 359869

  2. Human Monoclonal FLT3 Primary Antibody für FACS, IP - ABIN614773 : Rappold, Ziegler, Köhler, Marchetto, Rosnet, Birnbaum, Simmons, Zannettino, Hill, Neu, Knapp, Alitalo, Alitalo, Ullrich, Kanz, Bühring: Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase. in Blood 1997 (PubMed)
    Zeige alle 5 Referenzen für 614773

  3. Human Polyclonal FLT3 Primary Antibody für IHC (p), WB - ABIN391982 : Minami, Yamamoto, Kiyoi, Ueda, Saito, Naoe: Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia. in Blood 2003 (PubMed)
    Zeige alle 4 Referenzen für 391982

  4. Human Polyclonal FLT3 Primary Antibody für FACS, IHC (p) - ABIN391981 : Zwaan, Meshinchi, Radich, Veerman, Huismans, Munske, Podleschny, Hählen, Pieters, Zimmermann, Reinhardt, Harbott, Creutzig, Kaspers, Griesinger: FLT3 internal tandem duplication in 234 children with acute myeloid leukemia: prognostic significance and relation to cellular drug resistance. in Blood 2003 (PubMed)
    Zeige alle 4 Referenzen für 391981

  5. Human Polyclonal FLT3 Primary Antibody für IF, WB - ABIN401556 : Sekine, Kataoka, Fukuyama, Adachi, Davydova, Yamamoto, Kobayashi, Fujihashi, Suzuki, Curiel, Shizukuishi, McGhee, Fujihashi: A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature nasopharyngeal-associated lymphoreticular tissue dendritic cell migration. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)
    Zeige alle 3 Referenzen für 401556

  6. Human Polyclonal FLT3 Primary Antibody für ELISA, WB - ABIN1532338 : Rosnet, Schiff, Pébusque, Marchetto, Tonnelle, Toiron, Birg, Birnbaum: Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells. in Blood 1993 (PubMed)
    Zeige alle 2 Referenzen für 1532338

  7. Human Polyclonal FLT3 Primary Antibody für ELISA, WB - ABIN1532044 : Rosnet, Matteï, Marchetto, Birnbaum: Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene. in Genomics 1991 (PubMed)
    Zeige alle 2 Referenzen für 1532044

  8. Human Polyclonal FLT3 Primary Antibody für ELISA, WB - ABIN1531319 : Greenman, Stephens, Smith, Dalgliesh, Hunter, Bignell, Davies, Teague, Butler, Stevens, Edkins, OMeara, Vastrik, Schmidt, Avis, Barthorpe, Bhamra, Buck, Choudhury, Clements, Cole, Dicks, Forbes, Gray et al.: Patterns of somatic mutation in human cancer genomes. ... in Nature 2007 (PubMed)
    Zeige alle 2 Referenzen für 1531319

Weitere Antikörper gegen FLT3 Interaktionspartner

Mouse (Murine) Fms-Related tyrosine Kinase 3 (FLT3) Interaktionspartner

  1. the angiogenic factor (zeige VEGFA Antikörper) Egfl7 (zeige EGFL7 Antikörper) activates the Flt3/Flt3 ligand (zeige FLT3LG Antikörper) pathway and is a key molecular driver enforcing thymus progenitor generation and thereby directly links endothelial cell biology to the production of T cell-based adaptive immunity

  2. the Hoxa9 (zeige HOXA9 Antikörper)- and Meis1 (zeige MEIS1 Antikörper)-associated upregulation of Flt3 is a passive event with regard to leukemia development in mice and with limited relevance to the AML (zeige RUNX1 Antikörper) pathology.

  3. lineage-specific STAT5 (zeige STAT5A Antikörper) activation in hematopoietic progenitor cells predicts the FLT3(+)-mediated leukemic phenotype in mice

  4. DOCK2 (zeige DOCK2 Antikörper) is a potential therapeutic target for novel AML (zeige RUNX1 Antikörper) treatments, as this protein regulates the survival of leukemia cells with elevated FLT3 activity and sensitizes FLT3/ITD leukemic cells to conventional antileukemic agents.

  5. Used a genetic model to determine whether miR (zeige MLXIP Antikörper)-155 influences the development of FLT3-ITD-induced myeloproliferative disease. miR (zeige MLXIP Antikörper)-155 promotes FLT3-ITD-induced myeloid expansion in the bone marrow, spleen, and peripheral blood. Mechanistically, miR (zeige MLXIP Antikörper)-155 increases proliferation of the hematopoietic stem and progenitor cell compartments by reducing the growth-inhibitory effects of the interferon (zeige IFNA Antikörper) response.

  6. Overexpression of Abl (zeige ABL1 Antikörper)-related gene tyrosine kinase (zeige TYRO3 Antikörper) ABL2 in pro-B cell line Ba/F3 cells expressing an oncogenic mutant of FLT3 (FLT3-ITD) resulted in partial inhibition of FLT3-ITD-dependent cell proliferation.

  7. Sorafenib-resistant leukemia cells with a FLT3/ITD mutation are sensitive to glycolytic inhibitors.

  8. FLT3-ITD is capable of inhibiting FLT3-ITD+ cell proliferation through the p21 (zeige D4S234E Antikörper)/Pbx1 (zeige PBX1 Antikörper) axis

  9. Data indicate that most Fms-like tyrosine kinase-3 (FLT3) tyrosine kinase (zeige TYRO3 Antikörper) inhibitors (TKI) effectively target wild-type FLT3 signaling.

  10. DNMT3A (zeige DNMT3A Antikörper) haploinsufficiency results in reversible epigenetic alterations that transform FLT3(ITD)-mutant myeloproliferative neoplasm into AML (zeige RUNX1 Antikörper).

Human Fms-Related tyrosine Kinase 3 (FLT3) Interaktionspartner

  1. FLT3 mutation is associated with Metaplastic Breast Cancer.

  2. Collectively, we have developed a novel targeted therapeutic strategy, using FLT3L (zeige FLT3LG Antikörper)-guided miR (zeige MLXIP Antikörper)-150-based nanoparticles, to treat FLT3-overexpressing AML (zeige RUNX1 Antikörper) with high efficacy and minimal side effects.

  3. Y842 is critical for FLT3-mediated RAS/ERK (zeige EPHB2 Antikörper) signaling and cellular transformation.

  4. value of FLT3-ITD allelic ratio in AML (zeige RUNX1 Antikörper) in risk assessment and evaluating prognosis

  5. DOCK2 (zeige DOCK2 Antikörper) is a potential therapeutic target for novel AML (zeige RUNX1 Antikörper) treatments, as this protein regulates the survival of leukemia cells with elevated FLT3 activity and sensitizes FLT3/ITD leukemic cells to conventional antileukemic agents.

  6. Gedatolisib significantly extended survival of mice in a sorafenib-resistant acute myeloid leukemia (zeige BCL11A Antikörper) (AML (zeige RUNX1 Antikörper)) patient-derived xenograft model. Taken together, our data suggest that aberrant activation of the PI3K (zeige PIK3CA Antikörper)/mTOR (zeige FRAP1 Antikörper) pathway in FLT3-ITD-dependent AML (zeige RUNX1 Antikörper) results in resistance to drugs targeting FLT3.

  7. HHEX (zeige HHEX Antikörper) could replace RUNX1 (zeige RUNX1 Antikörper) in cooperating with FLT3-ITD to induce Acute myeloid leukemia (zeige BCL11A Antikörper) (AML (zeige RUNX1 Antikörper)).

  8. mutated FLT3-ITD and JAK2 (zeige JAK2 Antikörper) augment reactive oxygen species production and homologous recombination, shifting the cellular milieu toward illegitimate recombination.

  9. these data reveal a novel mechanism which regulates acute myeloid leukemia (zeige BCL11A Antikörper) cell death by ceramide-dependent mitophagy in response to FLT3-ITD targeting.

  10. MSI2 (zeige MSI2 Antikörper) and FLT3 are significantly co-regulated in human AML (zeige RUNX1 Antikörper)

FLT3 Antigen-Profil

Beschreibung des Gens

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Alternative names and synonyms associated with FLT3

  • fms-related tyrosine kinase 3 (FLT3) Antikörper
  • FMS-like tyrosine kinase 3 (Flt3) Antikörper
  • fms-related tyrosine kinase 3 (Flt3) Antikörper
  • B230315G04 Antikörper
  • CD135 Antikörper
  • FLK-2 Antikörper
  • FLK2 Antikörper
  • Flt-3 Antikörper
  • FLT3 Antikörper
  • Ly72 Antikörper
  • STK1 Antikörper
  • wmfl Antikörper

Bezeichner auf Proteinebene für FLT3

fms-related tyrosine kinase 3 , FL cytokine receptor-like , FL cytokine receptor , fetal liver kinase 2 , receptor-type tyrosine-protein kinase FLT3 , tyrosine-protein kinase FLT3 , tyrosine-protein kinase receptor flk-2 , CD135 antigen , STK-1 , fms-like tyrosine kinase 3 , growth factor receptor tyrosine kinase type III , stem cell tyrosine kinase 1 , FMS-like tyrosine kinase 3

GENE ID SPEZIES
452508 Pan troglodytes
100061780 Equus caballus
100413316 Callithrix jacchus
14255 Mus musculus
2322 Homo sapiens
140635 Rattus norvegicus
486025 Canis lupus familiaris
512700 Bos taurus
100858422 Gallus gallus
100515445 Sus scrofa
100732047 Cavia porcellus
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