anti-Ratte (Rattus) FGFR4 Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended FGFR4 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Fibroblast Growth Factor Receptor 4 (FGFR4) Antikörper
  • FGFR4
  • XFGFR-4
  • XFGFR-4a
  • cd334
  • fgfr-4
  • jtk2
  • tkf
  • xfgfr4
  • CD334
  • JTK2
  • TKF
  • Fgfr-4
  • etID309818.21
  • wu:fc13h10
  • zgc:111935
  • fgfr-4c
  • fgfr4
  • fibroblast growth factor receptor 4
  • FGFR4
  • fgfr4
  • Fgfr4
  • fgfr4-b
Epitop
AA 40-90
20
18
15
13
9
8
7
6
6
4
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
207
55
44
3
3
Wirt
Kaninchen
126
69
27
1
Klonalität
Polyklonal
Konjugat
Dieser FGFR4 Antikörper ist unkonjugiert
8
8
7
4
4
4
4
4
4
4
3
3
3
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
155
97
55
48
34
29
12
9
9
6
4
3
2
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN671766
$ 295.90
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN2001665 ELISA IHC (p) Rabbit IgG AA 1-367 Anmelden zum Anzeigen Polyclonal
1 ABIN671775 IHC (p) WB HRP Rabbit IgG AA 40-90 Anmelden zum Anzeigen Polyclonal
1 ABIN671768 IHC (p) WB Biotin Rabbit IgG AA 40-90 Anmelden zum Anzeigen Polyclonal

General

Antigen Fibroblast Growth Factor Receptor 4 (FGFR4) Antikörper
Epitop AA 40-90
(20), (18), (15), (13), (9), (8), (7), (6), (6), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(207), (55), (44), (3), (3)
Wirt Kaninchen
(126), (69), (27), (1)
Klonalität
Polyklonal
Konjugat Dieser FGFR4 Antikörper ist unkonjugiert
(8), (8), (7), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(155), (97), (55), (48), (34), (29), (12), (9), (9), (6), (4), (3), (2), (2), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-FGFR4 Antikörper

Target Details FGFR4 Anwendungsinformationen Handhabung Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human FGFR4
Isotyp IgG

Target Details FGFR4

Produktdetails anti-FGFR4 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung FGFR4/CD334 (FGFR4 Antibody Abstract)
Hintergrund

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation, MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

Subcellular location: Extracellular

Synonyms: TKF, JTK2, CD334, Fibroblast growth factor receptor 4, FGFR-4, FGFR4

Gen-ID 2264
UniProt P22455
Pathways RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Growth Factor Binding

Anwendungsinformationen

Produktdetails anti-FGFR4 Antikörper Target Details FGFR4 Handhabung Bilder zurück nach oben
Applikationshinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-FGFR4 Antikörper Target Details FGFR4 Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Bilder

Produktdetails anti-FGFR4 Antikörper Target Details FGFR4 Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Fibroblast Growth Factor Receptor 4 (FGFR4) (AA 40-90) antibody (ABIN671766) Formalin-fixed and paraffin embedded rat brain labeled Anti-FGFR4 Polyclonal Antibody...
Immunohistochemistry (IHC) image for anti-Fibroblast Growth Factor Receptor 4 (FGFR4) (AA 40-90) antibody (ABIN671766) Formalin-fixed and paraffin embedded human cervical carcinoma labeled Anti-FGFR4 Poly...