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anti-Human FGFR2 Antikörper:
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anti-Rat (Rattus) FGFR2 Antikörper:
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Human Monoclonal FGFR2 Primary Antibody für IHC (p), ELISA - ABIN560876
Ozawa, Yang, Ealy: The expression of fibroblast growth factor receptors during early bovine conceptus development and pharmacological analysis of their actions on trophoblast growth in vitro. in Reproduction (Cambridge, England) 2013
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Human Polyclonal FGFR2 Primary Antibody für FACS, IF - ABIN391965
Freeman, Gangula, Welm, Ozen, Foster, Rosen, Ittmann, Greenberg, Spencer et al.: Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase ... in Cancer research 2003
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Cow (Bovine) Polyclonal FGFR2 Primary Antibody für WB - ABIN611352
Steegmaier, Yang, Yoo, Huang, Shen, Yu, Luo, Scheller: Three novel proteins of the syntaxin/SNAP-25 family. in The Journal of biological chemistry 1999
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Human Monoclonal FGFR2 Primary Antibody für CyTOF, FACS - ABIN4900758
Rossi, Jeker, Ueno, Kuse, Keller, Zuklys, Gudkov, Takahama, Krenger, Blazar, Holländer: Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells. in Blood 2007
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Human Monoclonal FGFR2 Primary Antibody für CyTOF, FACS - ABIN4900757
Di Maggio, Mehrkens, Papadimitropoulos, Schaeren, Heberer, Banfi, Martin: Fibroblast growth factor-2 maintains a niche-dependent population of self-renewing highly potent non-adherent mesenchymal progenitors through FGFR2c. in Stem cells (Dayton, Ohio) 2012
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Human Polyclonal FGFR2 Primary Antibody für ELISA, WB - ABIN314240
McGrath, Lee, Buring, Hunter, De Vivo: Novel breast cancer risk alleles and endometrial cancer risk. in International journal of cancer 2008
Human Polyclonal FGFR2 Primary Antibody für IHC, IHC (p) - ABIN4311537
Tchaicha, Akbay, Altabef, Mikse, Kikuchi, Rhee, Liao, Bronson, Sholl, Meyerson, Hammerman, Wong: Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC. in Cancer research 2014
Human Monoclonal FGFR2 Primary Antibody für CyTOF, FACS - ABIN4900759
Ponte, Marais, Gallay, Langonné, Delorme, Hérault, Charbord, Domenech: The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. in Stem cells (Dayton, Ohio) 2007
Studies indicate that therapeutically targeting FGF2 (zeige FGF2 Antikörper) and FGFR has been extensively assessed in multiple preclinical studies and numerous drugs and treatment options have been tested in clinical trials.
We demonstrate that the bent bone dysplasia syndrome mutations in FGFR2 p.M391R and p.Y381D augment the ability of FGFR2 to epigenetically activate rDNA. Mutations p.M391R and p.Y381D activate the p53 (zeige TP53 Antikörper) nucleolar stress response pathway and alter FGFR2-mediated activation of ribosome biogenesis.
Polyclonal secondary FGFR2 mutations represent an important clinical resistance mechanism to protein kinase (zeige CDK7 Antikörper) inhibitors in patients with FGFR2 fusion-positive cholangiocarcinoma.
CD44 (zeige CD44 Antikörper) and FGFR2 maintain stemness in gastric cancer by differentially regulating c-Myc (zeige MYC Antikörper) transcription.
FGFR2, TWIST1 (zeige TWIST1 Antikörper), and FGFR3 (zeige FGFR3 Antikörper) mutations were identified in children with tracheal cartilaginous sleeve (TCS). All five children with a W290C mutation in FGFR2 had TCS, and most previously reported children with W290C had identification of TCS or early death
a novel identical postzygotic activating FGFR2 mutation in two unrelated fetuses with papillomatous pedunculated sebaceous naevus.
Findings suggest fibroblast growth factor receptor 2 (FGFR2) as a therapeutic target for esophagogastric junction (EGJ) adenocarcinoma.
Description of these patients expands the prenatal and postnatal findings of Bent Bone Dysplasia-FGFR2 type and adds to the phenotypic spectrum among all FGFR2 disorders.
Our results imply that the same FGFR2 mutations result in diverse phenotypes, and that genetic studies are recommended not only for obviously affected individuals but also for family members with apparently normal phenotype or non-specific subtle abnormal phenotype.
Liensinine inhibits FGFR2 activity.
Testis determination involves FGFR2c-mediated repression of both the WNT4 (zeige WNT4 Antikörper)- and FOXL2 (zeige FOXL2 Antikörper)-driven ovarian-determining pathways.
the localization of FGF9 and its receptors at different embryonic and postnatal stages in mice testes, was examined.
FGFR2 signalling correlates with maintenance of expression of a key transcription factor for basal cell self-renewal and differentiation: SOX2 (zeige SOX2 Antikörper).
Fgfr2 is seen within submucosal glandular epithelial cells. The medial nasal glands were missing in Fgfr2b mutants.
It is well accepted that myelin is a biologically active membrane in active communication with the axons. However, the axonal signals, the receptors on myelin, and the integration of intracellular signaling pathways emanating downstream from these receptors that drive the growth of the myelin sheath remain poorly understood in the CNS. This study brings up the intriguing possibility that FGF receptor 2, in the oligodendr
data suggest that FGF2 (zeige FGF2 Antikörper) levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor (zeige NR3C1 Antikörper) expression, an effect that is likely receptor mediated, albeit not by FGFR1 (zeige FGFR1 Antikörper), FGFR2, and FGFR3 (zeige FGFR3 Antikörper).
Results show that Fgfr2 regulates both the formation and resolution of tetrads and rosettes in the mouse embryo, possibly in part by spatially restricting atypical protein kinase C (zeige PRKCZ Antikörper), a negative regulator of non-muscle myosin IIB (zeige MYH10 Antikörper).
FGFR2c signaling regulates branching morphogenesis through the activation of FGFR2b signaling via increased FGF10 (zeige FGF10 Antikörper) autocrine. These results provide new insight into the mechanisms by which crosstalk between FGFR2b and FGFR2c results in efficient branching morphogenesis.
Fgfr2 is critical for bladder mesenchyme patterning by virtue of its role in modulation of hedgehog (zeige SHH Antikörper) signaling
Ectopic expression of Fgfr2c was detected within the affected sutures of Bcl11b (zeige BCL11B Antikörper)(-/-) mice. Ectopic expression of Fgfr2c in the sutural mesenchyme, without concomitant changes in the expression of FGF ligands, appears to induce the RUNX2 (zeige RUNX2 Antikörper)-dependent osteogenic program and craniosynostosis in Bcl11b (zeige BCL11B Antikörper)(-/-) mice.
mRNA and protein expression of FGFR-1 (zeige FGFR1 Antikörper), FGFR-2 in the porcine umbilical cord during pregnancy.
EGFR (zeige EGFR Antikörper), VEGFR (zeige KDR Antikörper) and FGFR are expressed in porcine oviduct and endometrium during the time of implantation [review]
analysis of regulation of endometrial fibroblast growth factor 7 (FGF-7 (zeige FGF7 Antikörper)) and its receptor FGFR2IIIb
activation of FGFR1 (zeige FGFR1 Antikörper) and FGFR2 by uterine- and endometrial-derived FGF2 (zeige FGF2 Antikörper) stimulates PI3K/AKT (zeige AKT1 Antikörper) and mitogen-activated protein kinase (zeige MAPK1 Antikörper) pathways for development of the porcine uterus and improvement of litter size
it is highly likely that the missense mutation in the FGFR2 gene caused the bovine facial dysplasia syndrome phenotype in a dominant mode of inheritance.
FGF10 (zeige FGF10 Antikörper) and its receptor FGFR2b are more expressed in subordinate follicles; FGF10 (zeige FGF10 Antikörper) acts as an important regulator of follicular growth in cattle.
Alterations in the expression of VEGF-A (zeige VEGFA Antikörper) and bFGF (zeige FGF2 Antikörper) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
These data support a role for FGF10 (zeige FGF10 Antikörper) and fibroblast growth factor receptor 2B in signaling to granulosa cells from theca cells and/or the oocyte.(fibroblast growth factor receptor 2B)
FGF10 (zeige FGF10 Antikörper) mRNA expression did not change during functional luteolysis, whereas FGFR2B mRNA abundance decreased significantly at 2, 4, and 12 hr after PGF2alpha, and returned to pretreatment levels for the period 24-64 hr post-PGF2alpha
we show that minimal amounts of Fgfr1a or Fgfr2 are required to initiate a regulatory cascade in pharyngeal endoderm reducing expression of fsta, thereby allowing correct BMP signaling to the maturing chondrocytes of the head cartilage.
the roles of Fgfr2 signaling in zebrafish left-right asymmetry
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
fibroblast growth factor receptor 2
, bacteria-expressed kinase
, keratinocyte growth factor receptor
, fibroblast growth factor receptor 2 IIIb
, fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)
, BEK fibroblast growth factor receptor
, FGF receptor
, hydroxyaryl-protein kinase
, protein tyrosine kinase, receptor like 14
, soluble FGFR4 variant 4
, FGF-7 receptor 2IIIb
, fgf receptor
, chicken tyrosine kinase (cek3)
, receptor tyrosine kinase
, tyrosine kinase receptor CEK3
, fibroblast growth factor receptor-2