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anti-Human FGF21 Antikörper:
anti-Mouse (Murine) FGF21 Antikörper:
anti-Rat (Rattus) FGF21 Antikörper:
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Human Polyclonal FGF21 Primary Antibody für ELISA, WB - ABIN314287
Inagaki, Dutchak, Zhao, Ding, Gautron, Parameswara, Li, Goetz, Mohammadi, Esser, Elmquist, Gerard, Burgess, Hammer, Mangelsdorf, Kliewer: Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. in Cell metabolism 2007
Human Polyclonal FGF21 Primary Antibody für IF (p), IHC (p) - ABIN679478
Dong, Yu, Wu, Wang, Niu, Wang, Zou: Echinacoside Induces Apoptosis in Human SW480 Colorectal Cancer Cells by Induction of Oxidative DNA Damages. in International journal of molecular sciences 2015
cholestasis could induce FGF21 expression in FXR (zeige NR1H4 Antikörper) dependent manner
Serum concentrations of FGF21 are elevated in patients with non-HIV lipodystrophy with adipose tissue and liver being potential sources of increased production. TG and fibrate treatment are independent positive predictors of circulating FGF21.
FGF21 concentration in plasma is increased in patients with obesity, insulin (zeige INS Antikörper) resistance, and metabolic syndrome. Recent findings suggest that such increment protects tissue from an increased oxidative stress environment. (Review)
FGF21 appears to act in a paracrine manner to increase glucose uptake under low insulin (zeige INS Antikörper) conditions, but it does not contribute to the resistance to diet-induced obesity.
Insulin (zeige INS Antikörper) rather than glucose per se increases total and bioactive FGF21 in the postprandial period in adult humans.
FGF21 has a role in promoting remyelination in the central nervous system
FGF21 genotypes may interact with dietary carbohydrate/fat intake on changes in central adiposity and body fat composition. A low-calorie, high-carbohydrate/low-fat diet was beneficial for overweight or obese individuals carrying the carbohydrate intake-decreasing allele of the FGF21 variant to improve body composition and abdominal obesity.
serum FGF19 (zeige FGF19 Antikörper) and FGF21 and hepatic Klotho (zeige KL Antikörper) expression are inversely associated with hepatic damage in children with NAFLD (zeige TSC2 Antikörper)
Higher vitamin D status, but not FGF21, was associated with greater postprandial glucose oxidation and improved insulin (zeige INS Antikörper) sensitivity in metabolic syndrome.
dietary protein dilution promotes improved glucose homeostasis through an select nonessential amino acids insufficiency-induced liver NUPR1 (zeige NUPR1 Antikörper)/FGF21 axis
The present study shows that expression of the FGF21 gene is strongly up-regulated during the transition period; the up-regulation of FGF21 might play an important role in the adaptation of liver metabolism during early lactation in dairy cows such as in other species.
RESULTS: The results showed that serum FGF-21 levels were significantly higher in both groups treated with a controlled-energy diet, while FGF-21 levels in both groups treated with moderate-energy diet were low.
liver-derived FGF21 regulates the use of lipid reserves during lactation via focal actions on liver and white adipose tissue.
This study demonstrates that FGF21 action is necessary to achieve the full metabolic benefits of exercise during chronic HF feeding.
mTORC1 mediated many of the beneficial actions of FGF21 in vitro, including UCP1 (zeige UCP1 Antikörper) and FGF21 induction, increased adiponectin secretion, and enhanced glucose uptake without any adverse effects on insulin (zeige INS Antikörper) action.
Data suggest that expression of Fgf21 in liver responds acutely to dietary protein intake; low-protein high-carbohydrate diet induces Fgf21 expression; high-protein low-carbohydrate diet reduces Fgf21 expression; Fgf21 expression/secretion in cultured hepatocytes appears to be controlled by glucose but not amino acids.
These findings reveal a previously unappreciated anti-inflammatory role for FGF21 in adipose tissue, but do not support that FGF21 is necessary for exercise-mediated anti-inflammatory effects.
our results reveal that ERRgamma (zeige ESRRG Antikörper), induced via activation of the hepatic CB1 (zeige CNR1 Antikörper) receptor, is a regulator of hepatic FGF21 gene expression and secretion.
OPA1 (zeige MED12 Antikörper) mutant mice are resistant to age- and diet-induced weight gain and insulin (zeige INS Antikörper) resistance, by mechanisms that involve activation of endoplasmic reticulum stress and secretion of fibroblast growth factor 21 (FGF21) from skeletal muscle, resulting in increased metabolic rates and improved whole-body insulin (zeige INS Antikörper) sensitivity.
FGF21 is not critical for bone homeostasis or actions of PPARalpha (zeige PPARA Antikörper) and PPARgamma (zeige PPARG Antikörper).
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
fibroblast growth factor 21