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anti-Mouse (Murine) FGF19 Antikörper:
anti-Rat (Rattus) FGF19 Antikörper:
anti-Human FGF19 Antikörper:
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Human Monoclonal FGF19 Primary Antibody für ELISA, WB - ABIN523342
Shang, Guo, Honda, Saumoy, Salen, Xu: FGF15/19 protein levels in the portal blood do not reflect changes in the ileal FGF15/19 or hepatic CYP7A1 mRNA levels. in Journal of lipid research 2013
Fgf15 is the sonic hedgehog (zeige SHH Antikörper) downstream signal to control thalamic regionalization, neurogenesis, and neuronal differentiation by regulating the expression and mutual segregation of neurogenic and proneural regulatory genes.
human microbiota was able to reduce the levels of tauro-beta-muricholic acid and induce expression of FXR (zeige NR1H4 Antikörper) target genes Fgf15 and Shp (zeige LAMC1 Antikörper) in ileum after long-term colonization. We show that a human microbiota can change BA composition and induce FXR (zeige NR1H4 Antikörper) signaling in colonized mice, but the levels of secondary BAs produced are lower than in mice colonized with a mouse microbiota
This study demonstrates that the FGF19-SHP (zeige LAMC1 Antikörper)-LSD1 (zeige KDM1A Antikörper) axis maintains homeostasis by suppressing unnecessary autophagic breakdown of cellular components, including lipids, under nutrient-rich postprandial conditions.
The elevation in circulating levels of adiponectin and Fgf15 led to normalized hepatic and serum levels of bile acids, limited hepatic accumulation of toxic bile, attenuated inflammation, and amelioration of liver injury in the ethanol-fed mNT knockout mice.
This study reveals SHP (zeige LAMC1 Antikörper) as a global transcriptional partner of SREBP-2 (zeige SREBF2 Antikörper) in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19.
Protective effects of farnesoid X receptor (zeige xpr1 Antikörper) on hepatic lipid accumulation are mediated by hepatic FXR (zeige NR1H4 Antikörper) and are independent of intestinal FGF15 signaling.
In mice with humanized livers human hepatocytes do not recognize FGF-15 produced by mouse intestine, resulting in up-regulation of bile acid synthesis enlargement of the bile acid pool, affecting the hepatostat.
Intestinal PPARalpha (zeige PPARA Antikörper)-UDP- Glucuronyltransferases and downstream FXR (zeige NR1H4 Antikörper)-FGF15 signalling play vital roles in control of bile acid homeostasis and the pathological development of colitis.
a direct role of intestinal FGF15/19 in the regulation of SI P450 (zeige POR Antikörper) expression and may have profound implications for the prediction of drug exposure in patients with compromised hepatic P450 (zeige POR Antikörper) function
findings implicate the brain in the antidiabetic action of systemic FGF19 and establish the brain's capacity to rapidly, potently, and selectively increase insulin (zeige INS Antikörper)-independent glucose disposal
serum FGF19 and FGF21 (zeige FGF21 Antikörper) and hepatic Klotho (zeige KL Antikörper) expression are inversely associated with hepatic damage in children with NAFLD (zeige TSC2 Antikörper)
Administering FGF19, or suitable mimetic, as a pharmacological intervention to increase circulating levels of FGF19 and suppress BA synthesis by inhibiting CYP7A1 (zeige CYP7A1 Antikörper) gene expression is likely to provide therapeutic benefits for many PBC (zeige DLAT Antikörper) patients
Amplification of FGF19 was validated in independent LSCC samples. Furthermore, FGF19 stimulated LSCC cell growth in vitro. These data implicate FGF19 as a potential driver gene in LSCC with clinic characteristics as smoking.
FGF19 is able to enhance migration and invasion abilities of gastric cancer cells.
Bile acid and FGF19 levels increased after Roux-en-Y bypass, but not after intensive medial management in type 2 diabetic subjects who achieved similar improvement in glycemic control.
FGF19 correlates with severity of liver disease and can potentially serve as an indicator of chronic cholestatic liver injury.
Study shows that FGF19 can be secreted and promotes ovarian cancer progression such as proliferation and invasion by activating FGFR4 (zeige FGFR4 Antikörper).
Suggest a potential connection between gallbladder cholangiocyte-derived FGF19 and bile acid metabolism that could lead to metabolic dysregulation following cholecystectomy.
FGF-19 increment after OGL was positively associated with age, and negatively associated with abnormal glucose regulation and statin treatment
KL methylation is a characteristic of many breast cancer cases . However, the resulting or associated perturbation in FGFR4 (zeige FGFR4 Antikörper) expression, similar to FGF19, could be utilized as a biomarker for poor prognosis
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.
fibroblast growth factor 19
, fibroblast growth factor 15