anti-Maus ERBB3 Antikörper für Immunoprecipitation

Recommended ERBB3 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Antikörper
  • ERBB3
  • ErbB-3
  • HER3
  • LCCS2
  • MDA-BF-1
  • c-erbB-3
  • c-erbB3
  • erbB3-S
  • p180-ErbB3
  • p45-sErbB3
  • p85-sErbB3
  • nuc-ErbB3
  • C76256
  • Erbb-3
  • Erbb3r
  • Her3
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
  • ERBB3
  • Erbb3
Epitop
AA 1283-1323, C-Term
41
40
37
27
21
19
15
15
15
15
15
14
13
12
10
10
10
9
8
7
7
5
5
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
535
198
172
14
7
6
6
4
3
3
3
2
2
2
2
1
1
Wirt
Kaninchen
302
230
28
4
Klonalität
Polyklonal
Konjugat
Dieser ERBB3 Antikörper ist unkonjugiert
14
13
12
11
11
11
8
8
8
8
7
6
6
5
5
5
5
5
5
4
3
3
3
3
3
3
3
3
2
Applikation
Immunoprecipitation (IP), Western Blotting (WB)
313
194
149
128
107
84
67
56
11
11
10
8
8
7
4
4
3
2
2
2
1
1
1
Hersteller
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Produktnummer ABIN5556680
$ 411.18
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN1490889 IP WB Biotin Mouse IgG1 AA 1234-1259 Anmelden zum Anzeigen 2B5
1 ABIN1867784 ICC IHC IP WB Rabbit IgG AA 707-964 Anmelden zum Anzeigen Polyclonal
1 ABIN213195 IP WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal
1 ABIN385583 IP WB Mouse IgG1 AA 1234-1259 Anmelden zum Anzeigen 2B5
1 ABIN385598 IP WB Mouse IgG1 AA 1234-1259 Anmelden zum Anzeigen 2C3
1 ABIN385582 IP WB Mouse IgG1 AA 1234-1259 Anmelden zum Anzeigen 2B5
1 ABIN385599 IP WB Mouse IgG1 AA 1234-1259 Anmelden zum Anzeigen 2C3
1 ABIN385588 IP WB Mouse IgG1 AA 1234-1259 Anmelden zum Anzeigen 2B5
1 ABIN385252 IP WB Mouse IgG2a, kappa Anmelden zum Anzeigen 2F12
1 ABIN385601 IP WB Mouse IgG1 AA 1234-1259 Anmelden zum Anzeigen 2C3
1 ABIN385251 IP WB Mouse IgG2a, kappa Anmelden zum Anzeigen 2F12
1 ABIN230900 IP WB Mouse IgG2a, kappa Anmelden zum Anzeigen
1 ABIN205790 IP WB Mouse IgG2a, kappa Anmelden zum Anzeigen
1 ABIN232947 IP WB Mouse IgG1 Anmelden zum Anzeigen
1 ABIN385556 FACS IF IP Mouse IgG1 Extracellular Domain Anmelden zum Anzeigen H3-105-5
1 ABIN385554 FACS IF IP Mouse IgG1 Extracellular Domain Anmelden zum Anzeigen H3-105-5
1 ABIN385254 IP WB Mouse IgG2a, kappa Anmelden zum Anzeigen 2F12
1 ABIN1901712 IP WB Rabbit AA 1292-1342 Anmelden zum Anzeigen Polyclonal
1 ABIN385557 Inhibition FACS IF IP Mouse IgG1 Extracellular Domain Anmelden zum Anzeigen H3-105-5 or AB105
1 ABIN1901710 IP Rabbit AA 1275-1325 Anmelden zum Anzeigen Polyclonal

General

Antigen V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Antikörper
Epitop AA 1283-1323, C-Term
(41), (40), (37), (27), (21), (19), (15), (15), (15), (15), (15), (14), (13), (12), (10), (10), (10), (9), (8), (7), (7), (5), (5), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(535), (198), (172), (14), (7), (6), (6), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1)
Wirt Kaninchen
(302), (230), (28), (4)
Klonalität
Polyklonal
Konjugat Dieser ERBB3 Antikörper ist unkonjugiert
(14), (13), (12), (11), (11), (11), (8), (8), (8), (8), (7), (6), (6), (5), (5), (5), (5), (5), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2)
Applikation Immunoprecipitation (IP), Western Blotting (WB)
(313), (194), (149), (128), (107), (84), (67), (56), (11), (11), (10), (8), (8), (7), (4), (4), (3), (2), (2), (2), (1), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-ERBB3 Antikörper

Target Details ERBB3 Anwendungsinformationen Handhabung Bilder
Spezifität The antibody is directed against Human HER3. It can detect HER3 from Human, Mouse and Rat sources. Reactivity of this antibody with HER3 from other species is unknown.
Produktmerkmale Concentration: 5.74 mg/mL (by UV absorbance at 280 nm)
Reinigung Protein A Chromatography followed by cross adsorption against GST and extensive dialysis against the buffer stated below.Assay by immunoelectro-phoresis resulted in a single precipitin arc against anti-Rabbit.
Immunogen This whole serum was prepared by repeated immunizations with a GST-HER3 fusion protein corresponding to amino acids 1283 to 1323 (40 amino acids) at the carboxy-terminus of human HER3.

Target Details ERBB3

Produktdetails anti-ERBB3 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung ERBB3 / HER3 (ERBB3 Antibody Abstract)
Hintergrund The human Epidermal Growth Factor Receptor (EGFR) family is a family of receptor tyrosine kinases consisting of 4 members: EGFR, HER2, HER3 and HER4. These receptors are expressed on a wide variety of tissue types and have been implicated in many human cancers, including breast, gastric, colon and prostate. Strong expression of both HER3 and HER2 (also known as p185neu) by tumor cells can be associated with poor outcome for patients. The ligand for HER3 and HER4 is called Neu Differentiation Factor (NDF) or Heregulin. In some instances, antibodies against these receptors prove effective in combination therapy regimens for treatment of the disease. Signaling through the EGFR family involves the combinatorial dimerization of the four known family members and is mediated by at least 8 different hormones, including EGF and the heregulins. Heregulin binding and tyrosine phosphorylation by HER3 or HER4 is enhanced in the presence of HER2. Structurally the members of the EGFR family are 1210 to 1342 amino acids in length with approximately 650 amino acids of the extracellular domain being heavily glycosylated. The extracellular domains show up to 70 % sequence homology.Synonyms: ERBB-3, HER-3, Proto-oncogene-like protein c-ErbB-3, Receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cell surface receptor HER3, c-erbB-3
Gen-ID 2065
NCBI Accession NP_001005915
UniProt P21860
Pathways RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung

Anwendungsinformationen

Produktdetails anti-ERBB3 Antikörper Target Details ERBB3 Handhabung Bilder zurück nach oben
Applikationshinweise Anti-HER3 antibody is specifically designed for Immunoprecipitation and can be used forImmunoblotting in conjunction with a detection antibody like anti-phosphotyrosine. Reactivity in other assays is likely, but has not been determined. Recognition of HER3 isindependent of the phosphorylation status of the molecule. Human prostate cell lines(LNCap) or human breast cell line (MDA-453) are typically used as positive control sources. Recommended Dilutions: Immunoprecipitation: Use approximately 5 μL of the antibody. The Immunoprecipitation
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-ERBB3 Antikörper Target Details ERBB3 Anwendungsinformationen Bilder zurück nach oben
Konzentration 5.74 mg/mL
Buffer 0.02 M potassium phosphate, 0.12 M sodium chloride, pH 7.2 with 0.01 % Sodium Azide as preservative without Stabilizers.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Dilute only prior to immediate use. Avoid cycles of freezing and thawing.
Lagerung -20 °C
Informationen zur Lagerung Store vial at -20 °C or below prior to opening. Aliquot contents and freeze at -20 °C or below.