anti-Human ERBB3 Antikörper für Immunohistochemistry (Formalin-fixed Sections)

Recommended ERBB3 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Antikörper
  • ERBB3
  • ErbB-3
  • HER3
  • LCCS2
  • MDA-BF-1
  • c-erbB-3
  • c-erbB3
  • erbB3-S
  • p180-ErbB3
  • p45-sErbB3
  • p85-sErbB3
  • nuc-ErbB3
  • C76256
  • Erbb-3
  • Erbb3r
  • Her3
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
  • ERBB3
  • Erbb3
Reaktivität
Human
535
199
173
14
7
6
6
4
3
3
3
2
2
2
2
1
1
Wirt
Maus
303
229
28
4
Klonalität
Monoklonal
Konjugat
Dieser ERBB3 Antikörper ist unkonjugiert
14
13
12
11
11
11
8
8
8
8
7
6
6
5
5
5
5
5
5
4
3
3
3
3
3
3
3
3
2
Applikation
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
313
194
149
128
107
84
67
56
11
11
10
8
8
6
4
4
3
2
2
2
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Request

Produkt kostenlos erhalten?

Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validieren

Mehr erfahren

Bilder

Produktnummer ABIN967437
Preis und Verfügbarkeit auf Anfrage.

General

Antigen V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Antikörper
Reaktivität Human
(535), (199), (173), (14), (7), (6), (6), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1)
Wirt Maus
(303), (229), (28), (4)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser ERBB3 Antikörper ist unkonjugiert
(14), (13), (12), (11), (11), (11), (8), (8), (8), (8), (7), (6), (6), (5), (5), (5), (5), (5), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2)
Applikation Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
(313), (194), (149), (128), (107), (84), (67), (56), (11), (11), (10), (8), (8), (6), (4), (4), (3), (2), (2), (2), (1), (1)
Pubmed 4 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-ERBB3 Antikörper

Target Details ERBB3 Anwendungsinformationen Handhabung Referenzen für anti-ERBB3 Antikörper (ABIN967437) Bilder
Marke BD Pharmingen™
Produktmerkmale 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Human c-erbB-3 Peptide
Klon RTJ-1
Isotyp IgM

Target Details ERBB3

Produktdetails anti-ERBB3 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-ERBB3 Antikörper (ABIN967437) Bilder zurück nach oben
Antigen
Andere Bezeichnung c-erbB-3 (ERBB3 Antibody Abstract)
Hintergrund C-erbB-3, a glycoprotein of 160 kD, is a member of the type 1 growth factor receptor subfamily which also includes c-erbB-2 (HER2/neu), c-erbB-4 and the epidermal growth factor receptor (EGFR, c-erbB-1). Members of this receptor subfamily mediate the proliferation and differentiation of normal cells. They have a common structure consisting of an extracellular domain, a transmembrane region, and a cytoplasmic sequence. The extracellular regions contain two cysteine-rich domains, and the intracellular regions have sequence homology to known tyrosine kinases. C-erbB-3 is expressed in tissues from the digestive, urinary and respiratory tracts, the circulatory system, and female and male reproductive organs. c-erb B-3 is undetectable in hematopoietic tissue and cell lines derived from hematopoietic tumors. Cellular localization has been described as cytoplasmic and/or membrane, and nuclear. The level and pattern of c-erbB-3 expression varies widely in both normal and tumor tissues.
Clone RTJ.1 recognizes an epitope in the cytoplasmic domain of the human c-erbB-3 protein. It does not react with the EGF receptor or c-erbB-2. A synthetic peptide (referred to as 49.3) from the cytoplasmic domain of human c-erbB-3 protein was used as immunogen. RTJ.1 identifies a 160 kD band corresponding to c-erbB-3 by western blot analysis and immunoprecipitation. RTJ.1 may also react with two additional, unidentified higher molecular weight bands by immunoprecipitation and western blot analysis. These bands are likely to be non-specific, as they were not detected with a polyclonal antibody raised against the same immunogen. Because two additional bands were observed, the specificity of RTJ.1 for immunohistochemistry was analyzed by comparing staining results to those obtained using three polyclonal antibodies also raised against 49.3. Identical staining results were obtained using RTJ.1 and all three polyclonal antibodies. These results validated the use of RTJ.1 for immunohistochemical analysis of c-erbB-3.
Molekulargewicht 160 kDa
Pathways RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung

Anwendungsinformationen

Produktdetails anti-ERBB3 Antikörper Target Details ERBB3 Handhabung Referenzen für anti-ERBB3 Antikörper (ABIN967437) Bilder zurück nach oben
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-ERBB3 Antikörper Target Details ERBB3 Anwendungsinformationen Referenzen für anti-ERBB3 Antikörper (ABIN967437) Bilder zurück nach oben
Format Liquid
Konzentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store undiluted at 4°C.

Referenzen für anti-ERBB3 Antikörper (ABIN967437)

Produktdetails anti-ERBB3 Antikörper Target Details ERBB3 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Carraway, Cantley: "A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling." in: Cell, Vol. 78, Issue 1, pp. 5-8, 1994

Rajkumar, Gooden, Lemoine, Gullick, Goden: "Expression of the c-erbB-3 protein in gastrointestinal tract tumours determined by monoclonal antibody RTJ1." in: The Journal of pathology, Vol. 170, Issue 3, pp. 271-8, 1994

Sanidas, Filipe, Linehan, Lemoine, Gullick, Rajkumar, Levison: "Expression of the c-erbB-3 gene product in gastric cancer." in: International journal of cancer. Journal international du cancer, Vol. 54, Issue 6, pp. 935-40, 1993

Prigent, Lemoine, Hughes, Plowman, Selden, Gullick: "Expression of the c-erbB-3 protein in normal human adult and fetal tissues." in: Oncogene, Vol. 7, Issue 7, pp. 1273-8, 1992

Bilder

Produktdetails anti-ERBB3 Antikörper Target Details ERBB3 Anwendungsinformationen Handhabung Referenzen für anti-ERBB3 Antikörper (ABIN967437) zurück nach oben
Bilder des Herstellers
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) antibody (ABIN967437) Formalin-fixed, paraffin-embedded tissue section of mouse thyroid stained with anti-c...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) antibody (ABIN967437) Formalin-fixed, paraffin-embedded tissue section of mouse thyroid stained with a mous...
 image for anti-V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) antibody (ABIN967437) anti-V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) antibody (Image 3)
Immunohistochemistry (IHC) image for anti-V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) antibody (ABIN967437) anti-V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) antibody (Image 4)