anti-Human ERBB3 Antikörper für Dot Blot

Recommended ERBB3 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Antikörper
  • ErbB-3
  • HER3
  • LCCS2
  • MDA-BF-1
  • c-erbB-3
  • c-erbB3
  • erbB3-S
  • p180-ErbB3
  • p45-sErbB3
  • p85-sErbB3
  • ERBB3
  • C76256
  • Erbb-3
  • Erbb3r
  • Her3
  • nuc-ErbB3
  • HER-3
  • erb-b2 receptor tyrosine kinase 3
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • hairy-related 3
  • ERBB3
  • Erbb3
  • her3
Epitop
pTyr1289
40
38
27
22
21
19
15
15
15
15
15
13
13
12
10
10
10
9
8
7
7
5
5
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
514
196
171
14
7
6
6
4
3
3
3
2
2
2
2
1
1
Wirt
Kaninchen
299
213
27
3
Klonalität
Polyklonal
Konjugat
Dieser ERBB3 Antikörper ist unkonjugiert
14
11
11
11
10
10
10
7
7
7
5
5
5
5
5
5
5
5
4
3
3
3
3
3
3
3
3
2
Applikation
Dot Blot (DB), Western Blotting (WB)
309
194
146
109
107
81
67
57
10
8
8
8
7
6
4
2
2
2
2
2
1
1
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN1881314
$ 324.50
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
29.605053 ABIN3029523 DB ELISA WB Rabbit Ig Fraction pTyr1289 Anmelden zum Anzeigen Polyclonal
1 ABIN2794312 DB WB Rabbit Ig Fraction pTyr1289 Anmelden zum Anzeigen Polyclonal

General

Antigen V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Antikörper
Epitop pTyr1289
(40), (38), (27), (22), (21), (19), (15), (15), (15), (15), (15), (13), (13), (12), (10), (10), (10), (9), (8), (7), (7), (5), (5), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human
(514), (196), (171), (14), (7), (6), (6), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1)
Wirt Kaninchen
(299), (213), (27), (3)
Klonalität (Klon)
Polyklonal   ( )
Konjugat Dieser ERBB3 Antikörper ist unkonjugiert
(14), (11), (11), (11), (10), (10), (10), (7), (7), (7), (5), (5), (5), (5), (5), (5), (5), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2)
Applikation Dot Blot (DB), Western Blotting (WB)
(309), (194), (146), (109), (107), (81), (67), (57), (10), (8), (8), (8), (7), (6), (4), (2), (2), (2), (2), (2), (1), (1), (1)
Pubmed 5 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-ERBB3 Antikörper

Target Details ERBB3 Anwendungsinformationen Handhabung Referenzen für anti-ERBB3 Antikörper (ABIN1881314) Bilder
Reinigung This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Immunogen This ERBB3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1289 of human ERBB3.
Klon RB25837

Target Details ERBB3

Produktdetails anti-ERBB3 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-ERBB3 Antikörper (ABIN1881314) Bilder zurück nach oben
Antigen
Andere Bezeichnung ERBB3 (ERBB3 Antibody Abstract)
Hintergrund This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form.

Synonyms: ERBB3, HER3, Receptor tyrosine-protein kinase erbB-3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3
NCBI Accession NP_001005915, NP_001973
UniProt P21860
Forschungsgebiet Receptors, Growth Factors, Cytokines
Pathways RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung

Anwendungsinformationen

Produktdetails anti-ERBB3 Antikörper Target Details ERBB3 Handhabung Referenzen für anti-ERBB3 Antikörper (ABIN1881314) Bilder zurück nach oben
Applikationshinweise DB: 1:500,WB: 1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-ERBB3 Antikörper Target Details ERBB3 Anwendungsinformationen Referenzen für anti-ERBB3 Antikörper (ABIN1881314) Bilder zurück nach oben
Format Liquid
Konzentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Referenzen für anti-ERBB3 Antikörper (ABIN1881314)

Produktdetails anti-ERBB3 Antikörper Target Details ERBB3 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Huang, Gao, Wang, McManaman, Thor, Yang, Esteva, Liu: "Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin." in: Cancer research, Vol. 70, Issue 3, pp. 1204-14, 2010

Pierce, Ahsan: "Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk." in: Human heredity, Vol. 69, Issue 3, pp. 193-201, 2010

Carr, Niederer, Williams, Harper, Watts, Lyons, Smith: "Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis." in: BMC medical genetics, Vol. 10, pp. 121, 2009

Zhang, Opresko, Shankaran, Chrisler, Wiley, Resat: "HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells." in: BMC cell biology, Vol. 10, pp. 78, 2009

Li, Feng, He: "Case-control study of association between the functional candidate gene ERBB3 and schizophrenia in Caucasian population." in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, Vol. 10, Issue 4 Pt 2, pp. 595-8, 2009

Bilder

Produktdetails anti-ERBB3 Antikörper Target Details ERBB3 Anwendungsinformationen Handhabung Referenzen für anti-ERBB3 Antikörper (ABIN1881314) zurück nach oben
Bilder des Herstellers
Dot Blot (DB) image for anti-V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) (pTyr1289) antibody (ABIN1881314) Dot blot analysis of anti-Phospho-ERBB3 (Tyr1289) Antibody Phospho-specific Pab (ABIN...
Western Blotting (WB) image for anti-V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) (pTyr1289) antibody (ABIN1881314) Dot blot analysis of anti-Phospho-ERBB3 (Tyr1289) Antibody Phospho-specific Pab (ABIN...