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anti-Mouse (Murine) Ephrin B2 Antikörper:
anti-Rat (Rattus) Ephrin B2 Antikörper:
anti-Human Ephrin B2 Antikörper:
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Human Polyclonal Ephrin B2 Primary Antibody für CyTOF, FACS - ABIN4900008
Zhang, Dong, Wang, Zhu, Croy: Dynamic changes occur in patterns of endometrial EFNB2/EPHB4 expression during the period of spiral arterial modification in mice. in Biology of reproduction 2008
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Human Polyclonal Ephrin B2 Primary Antibody für IHC - ABIN966079
Chrencik, Brooun, Kraus, Recht, Kolatkar, Han, Seifert, Widmer, Auer, Kuhn: Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity. in The Journal of biological chemistry 2006
Show all 3 Pubmed References
Human Polyclonal Ephrin B2 Primary Antibody für IHC, IHC (p) - ABIN4308730
Nakayama, Nakayama, van Lessen, Yamamoto, Hoffmann, Drexler, Itoh, Hirose, Breier, Vestweber, Cooper, Ohno, Kaibuchi, Adams: Spatial regulation of VEGF receptor endocytosis in angiogenesis. in Nature cell biology 2013
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Human Polyclonal Ephrin B2 Primary Antibody für IHC - ABIN966078
Noren, Lu, Freeman, Koolpe, Pasquale: Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth. in Proceedings of the National Academy of Sciences of the United States of America 2004
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Human Polyclonal Ephrin B2 Primary Antibody für IF, WB - ABIN362834
Kertesz, Krasnoperov, Reddy, Leshanski, Kumar, Zozulya, Gill: The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth. in Blood 2006
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Human Polyclonal Ephrin B2 Primary Antibody für ELISA, WB - ABIN4308729
Nakada, Anderson, Demuth, Nakada, Reavie, Drake, Hoelzinger, Berens: The phosphorylation of ephrin-B2 ligand promotes glioma cell migration and invasion. in International journal of cancer 2010
It functioned by interrupting the phosphorylation of EphrinB2 and its related signaling pathway.
EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 (zeige ADAM10 Antikörper) and flotillin-1 (zeige FLOT1 Antikörper).
As endothelial progenitor cells (EPCs)derived from mouse bone marrow were cultured on substrates of increasing stiffness, the mRNA and protein levels of the specific arterial endothelial cell marker ephrinB2 were found to increase, while the expression of the venous marker EphB4 (zeige EPHB4 Antikörper) decreased
an autonomous receptor-like role for ephrin-B reverse signaling in the tangential migration of interneurons into the neocortex using ephrin-B (EfnB1 (zeige EFNB1 Antikörper)/B2/B3) conditional triple mutant (TM(lz)) mice, is reported.
During urogenital development, different modes of Eph (zeige EPHA1 Antikörper)/Ephrin signaling occur at several sites with EphrinB2 and EphrinA5 acting in concert.
Male Efnb2 knockout mice presented reduced blood pressure. Region from aa 313 to aa 331 of EFNB2 was essential for reverse signaling regulating VSMC contractility.
Suggest role for ephrinB2/EphB4 (zeige EPHB4 Antikörper) signaling in the maintenance of neurovascular homeostasis and show that EphrinB2 activation promotes vascular repair mechanisms and reduces brain swelling after mild cerebral ischemia.
The Eph (zeige EPHA1 Antikörper)/ephrin-B2-mediated heterotypic or homotypic cell interactions between thymocytes and thymic epithelial cells (TECs), or between TECs and themselves, contribute to the early maturation of MTS20(+) TECs.
Control of abscission requires Eph (zeige EPHA1 Antikörper) kinase activity, and Src (zeige SRC Antikörper) and citron kinase (zeige CIT Antikörper) (CitK) are downstream effectors in the Eph (zeige EPHA1 Antikörper)-induced signal transduction cascade
The Netrin-1 (zeige NTN1 Antikörper) and ephrin-B2 synergistic growth cone responses involve the potentiation of Src (zeige SRC Antikörper) family kinase signaling, a common effector of both pathways.
in vivo study demonstrated, for the first time, that EFNB2 is essential for normal long bone growth and development
the role of ephrin B2 in endochondral ossification using Osx1Cre-targeted gene deletion, was investigated.
Proteomic analysis of their secretome reveals a signature, including ephrin-B2, that predicts decreased survival of glioma patients. We find that ephrin-B2 is an important pro-angiogenic tenascin-C (zeige TNC Antikörper) effector.
In human glioblastoma stem-like cells-derived orthotopic xenografts, EFNB2 knock-down blocked tumour initiation and treatment of established tumours with ephrin-B2-blocking antibodies suppressed progression.
High EFNB2 expression is associated with preeclampsia.
Inhibition of EphB4 (zeige EPHB4 Antikörper) forward signaling using soluble EphB4 (zeige EPHB4 Antikörper) protein fused (zeige AXIN1 Antikörper) with murine serum albumin (zeige ALB Antikörper) failed to affect eRMS model tumor progression, but did moderately slow progression in murine aRMS
Study shows that EFNB2 is overexpressed in head and neck squamous cell carcinoma, pancreatic adenocarcinoma, and urothelial bladder carcinoma, and its overexpression correlates with poor survival of the cancer patients.
Five SNPs in the 3' region of the EFNB2 were in linkage disequilibrium and significantly associated with hypertension for male but not female subjects.
These results indicate a novel mechanism of ephrin-Eph (zeige EPHA1 Antikörper) signaling independent of direct cell contact and proteolytic cleavage and suggest the participation of EphB2 (zeige EPHB2 Antikörper)(+)extracellular vesicles in neural development and synapse physiology.
Association of EFNB2 rs9520087 with symptoms of schizophrenia in Chinese Zhuang and Han populations.
miR (zeige MLXIP Antikörper)-137 directly down-regulates the expression of EFNB2, and a genetic variant in the RNA binding site in EFNB2 gene affects the expression regulation. MiR (zeige MLXIP Antikörper)-137, as a risk factor for schizophrenia
5-fluorouracil-induced ephrin-B2 reverse signaling promotes tumorigenesis through the Src (zeige SRC Antikörper)-ERK (zeige EPHB2 Antikörper) pathway, and drives EMT (zeige ITK Antikörper) via the Src (zeige SRC Antikörper)-FAK (zeige PTK2 Antikörper) pathway.
The porcine EFNB2 gene was characterized and cloned. The porcine EFNB2 gene was expressed in ten different tissues from 25-day-old Shaziling and Yorkshire piglets, with the highest expression observed in the longissimus dorsi.
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.
, ephrin-B2 precursor
, ephrin B2
, EPH-related receptor tyrosine kinase ligand 5
, HTK ligand
, eph-related receptor tyrosine kinase ligand 5
, ligand of eph-related kinase 5