anti-Maus EPH Receptor B4 Antikörper für Enzyme Immunoassay

Recommended EPH Receptor B4 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
EPH Receptor B4 (EPHB4) Antikörper
  • htk
  • myk1
  • ephB4a
  • tyro11
  • ephb4b
  • MGC130997
  • AI042935
  • Htk
  • MDK2
  • Myk1
  • Tyro11
  • HTK
  • MYK1
  • TYRO11
  • EPH receptor B4
  • Eph receptor B4
  • EPHB4
  • ephb4-a
  • ephb4
  • LOC100359286
  • Ephb4
Reaktivität
Maus
161
67
10
1
1
1
1
Wirt
Ratte
70
67
47
20
2
Klonalität
Monoklonal
Konjugat
Dieser EPH Receptor B4 Antikörper ist unkonjugiert
8
6
6
5
5
4
4
4
4
3
3
3
3
2
1
1
1
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
140
106
47
28
21
19
6
4
4
4
2
2
2
1
1
Hersteller
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Hersteller Produkt- Nr.
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Produktnummer ABIN1107116
$ 654.50
Zzgl. Versandkosten $45.00

General

Antigen EPH Receptor B4 (EPHB4) Antikörper
Reaktivität Maus
(161), (67), (10), (1), (1), (1), (1)
Wirt Ratte
(70), (67), (47), (20), (2)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser EPH Receptor B4 Antikörper ist unkonjugiert
(8), (6), (6), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
(140), (106), (47), (28), (21), (19), (6), (4), (4), (4), (2), (2), (2), (1), (1)
Pubmed 1 Publikation vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-EPH Receptor B4 Antikörper

Target Details EPH Receptor B4 Anwendungsinformationen Handhabung Referenzen für anti-EPH Receptor B4 Antikörper (ABIN1107116) Bilder
Kreuzreaktivität (Details) Species reactivity (tested):Mouse
Reinigung Purified
Klon VEB4-7E4
Isotyp IgG2a

Target Details EPH Receptor B4

Produktdetails anti-EPH Receptor B4 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-EPH Receptor B4 Antikörper (ABIN1107116) Bilder zurück nach oben
Antigen
Andere Bezeichnung EPHB4 (EPHB4 Antibody Abstract)
Hintergrund Erythropoietin-producing human hepatocellular carcinoma (Eph) receptors and ephrins are membrane proteins. They are classified into 2 broad subclasses, namely A and B, according to structural homologies and binding specificities. Eph receptors are tyrosine kinases, which autophosphorylate upon binding to their cognate ephrin ligands. Eph receptors and ephrins are frequently expressed in reciprocal patterns that correlate with cellular boundaries during embryonic development. The interaction between EphB4 and its ligand, Ephrin-B2, plays an important role in cell-cell, cell-extracellular matrix interactions as well as in cell migration, adhesion and proliferation. During the early stages of vascular development, EphB4 is specifically expressed in venous endothelium, whereas Ephrin-B2 is expressed in arterial endothelium. In mouse embryo's, EphB4 and Ephrin-B2 are essential for embryonic heart development and angiogenesis. In adult microcirculation, EphB4 is not a ubiquitous marker of arterial/venous polarity, but is expressed along both venules and arterioles. Furthermore, EphB4 is upregulated by endothelial cells along blind-ended capillary sprouts versus connecting capillaries. As such, EphB4 is thought to play a role in the patterning of new vessels during angiogenesis. EphB4 is also expressed in a variety of tumor cells, like gastrointestinal, prostate, bladder, breast, liver, lung and ovarian cancers, as well as leukemia, mesothelioma, malignant breast tumors and melanoma. Reduction of EphB4 activity accelerated tumorigenesis in colon and rectum. In head and neck squamous cell carcinoma and endometrial carcinoma, overexpression of EphB4 is inversely related to a poor prognosis. However, in mesothelioma, up-regulation of EphB4 resulted in growth of the tumor. Besides the essential expression of EphB4, coexpression of other EphB4 family members or EphB-ligands may affect tumor cell viability and proliferation as well.Synonyms: Ephrin type-B receptor 4, HTK, TYRO11, Tyrosine-protein kinase TYRO11, Tyrosine-protein kinase receptor HTK
Gen-ID 13846
NCBI Accession NP_034274
UniProt P54761
Pathways RTK Signalweg

Anwendungsinformationen

Produktdetails anti-EPH Receptor B4 Antikörper Target Details EPH Receptor B4 Handhabung Referenzen für anti-EPH Receptor B4 Antikörper (ABIN1107116) Bilder zurück nach oben
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-EPH Receptor B4 Antikörper Target Details EPH Receptor B4 Anwendungsinformationen Referenzen für anti-EPH Receptor B4 Antikörper (ABIN1107116) Bilder zurück nach oben
Konzentration 0.1 mg/mL
Buffer PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 2 - 8 °C.

Referenzen für anti-EPH Receptor B4 Antikörper (ABIN1107116)

Produktdetails anti-EPH Receptor B4 Antikörper Target Details EPH Receptor B4 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Huang, Yamada, Kidoya, Naito, Nagahama, Kong, Katoh, Li, Ueno, Takakura: "EphB4 overexpression in B16 melanoma cells affects arterial-venous patterning in tumor angiogenesis." in: Cancer research, Vol. 67, Issue 20, pp. 9800-8, 2007