anti-DDR2 (DDR2) Antikörper

Bezeichnung:
anti-Discoidin Domain Receptor tyrosine Kinase 2 Antikörper (DDR2)
Auf www.antikoerper-online.de finden Sie aktuell 116 Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) Antikörper von 19 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen DDR2 Proteine (33) und DDR2 Kits (11) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 174 DDR2 Produkte verfügbar.
Synonyme:
AW495251, ddr2, MIG20a, NTRKR3, si:ch211-193c2.1, TKT, Tyro10

Meistgesuchte Reaktivitäten zu anti-DDR2 (DDR2) Antikörper

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anti-Mouse (Murine) DDR2 Antikörper:

anti-Human DDR2 Antikörper:

anti-Rat (Rattus) DDR2 Antikörper:

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Am meisten referenzierte anti-DDR2 Antikörper

  1. Human Polyclonal DDR2 Primary Antibody für EIA, WB - ABIN359957 : Vogel, Gish, Alves, Pawson: The discoidin domain receptor tyrosine kinases are activated by collagen. in Molecular cell 1998 (PubMed)
    Zeige alle 5 Referenzen für 359957

  2. Human Polyclonal DDR2 Primary Antibody für EIA, WB - ABIN359956 : Karn, Holtrich, Bräuninger, Böhme, Wolf, Rübsamen-Waigmann, Strebhardt: Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain. in Oncogene 1993 (PubMed)
    Zeige alle 5 Referenzen für 359956

  3. Human Polyclonal DDR2 Primary Antibody für WB - ABIN392068 : Edelhoff, Sweetser, Disteche: Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C. in Genomics 1995 (PubMed)
    Zeige alle 5 Referenzen für 392068

  4. Human Monoclonal DDR2 Primary Antibody für ICC, IHC - ABIN969083 : Leitinger, Kwan: The discoidin domain receptor DDR2 is a receptor for type X collagen. in Matrix biology : journal of the International Society for Matrix Biology 2006 (PubMed)
    Zeige alle 3 Referenzen für 969083

  5. Mouse (Murine) Polyclonal DDR2 Primary Antibody für ELISA, IHC (p) - ABIN2001101 : Zhang, Ding, Zhang, Su, Li, Liu, Ma, Yao: Expression of discoidin domain receptor 2 (DDR2) extracellular domain in pichia pastoris and functional analysis in synovial fibroblasts and NIT3T3 cells. in Molecular and cellular biochemistry 2006 (PubMed)
    Zeige alle 2 Referenzen für 2001101

  6. Human Polyclonal DDR2 Primary Antibody für IF (p), IHC (p) - ABIN755218 : Wang, Wang, Zhao, Li, Deng: Angiotensin II upregulates K(Ca)3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts. in Biochemical pharmacology 2013 (PubMed)
    Zeige alle 2 Referenzen für 755218

Weitere Antikörper gegen DDR2 Interaktionspartner

Mouse (Murine) Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) Interaktionspartner

  1. circulating fibroblast precursors expressing DDR2, in an exposure-induced model of pulmonary fibrosis, is reported.

  2. This work identifies DDR2 as a potential therapeutic target that controls breast cancer metastases through its action in both tumor cells and tumor-stromal cells at the primary tumor site.

  3. The progressive process of articular cartilage degeneration was significantly delayed in the knee joints of Ddr2-deficient mice in comparison to their control littermates. Articular cartilage damage in the knee joints of the mice was associated with increased expression profiles of both Ddr2 and matrix metalloproteinase 13 (zeige MMP13 Antikörper).

  4. DDR2 mutation can drive lung cancer initiation in vivo and provide a novel mouse model for lung cancer therapeutics studies.

  5. Study showed that Nrp1 (zeige NRP1 Antikörper) expression paralleled with that of DDR2 during osteoblast differentiation. Nrp1 (zeige NRP1 Antikörper) assisted the promoting role of DDR2 in osteoblast differentiation, via activation of DDR2-mediated downstream signaling.

  6. Data show that discoidin domain receptor (DDR (zeige DDR1 Antikörper)) 2 siRNA-mediated suppression of extracellular regulated kinase (ERK) 1 (zeige MAPK3 Antikörper) and 2 and nuclear factor of kappa B (NF-kappaB (zeige NFKB1 Antikörper)) could down-regulate the expressions of matrix metalloproteinase (MMP) 2 (zeige MMP2 Antikörper) and 9.

  7. RESULTS Data show that DDR2 (discoidin domain receptor 2) suppresses osteoclast differentiation and activity.

  8. DDR2 signaling regulates cell proliferation and extracellular matrix synthesis, which are key aspects of fibroblast contribution to tissue healing [review]

  9. Germline deletion of the DDR2 results in smaller hearts, shorter cardiomyocytes, lower interstitial cardiac collagen density and abnormalities in cardiac function.

  10. Taken together, our data demonstrated that DDR2 might play a systemic role in the regulation of body size thorough skeletal formation and fat metabolism.

Human Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) Interaktionspartner

  1. This study suggested that DDR1 (zeige DDR1 Antikörper) and DDR2 knockdown alters brain immunity and significantly reduces the level of triggering receptor expressed on myeloid cells (TREM)-2 (zeige TREM2 Antikörper) and microglia.

  2. This work identifies DDR2 as a potential therapeutic target that controls breast cancer metastases through its action in both tumor cells and tumor-stromal cells at the primary tumor site.

  3. The group of patients with colorectal cancer with high DDR2 expression had significantly higher frequencies of T4, lymph node metastasis, and peritoneal dissemination compared to the group with low DDR2 expression.

  4. DDR2 showed high expression in gastric cancer tissues and cells. In xenograft models, DDR2 overexpression promoted tumor formation. Furthermore, DDR2 expression impacted on the invasion and motility of GC cells, accompanied by changes in EMT (zeige ITK Antikörper) marker expression. Finally, our results revealed that DDR2 facilitates GC cell invasion and EMT (zeige ITK Antikörper) through mTORC2 (zeige CRTC2 Antikörper) activation and AKT (zeige AKT1 Antikörper) phosphorylation.

  5. DDR2 mediates collagen-induced activation of MT1-MMP (zeige MMP14 Antikörper) in human fibroblasts

  6. Study strongly suggests that during pulmonary fibrosis, DDR2 not only participates in both the initiation and maintenance of fibrotic reaction, but also affects both ECM (zeige MMRN1 Antikörper) production and angiogenesis.

  7. signaling pathway, effectively suppressed peritoneal dissemination. DDR2 was identified as a driver gene for Gastric Cancer dissemination from the combined expression signature and can potentially serve as a novel therapeutic target for inhibiting Gastric Cancer peritoneal dissemination.

  8. Ang II (zeige AGT Antikörper) induces cardiac fibrosis by enhancing DDR2 expression in cardiac fibroblasts via p38 MAPK (zeige MAPK14 Antikörper)-mediated activation of NF-kappaB (zeige NFKB1 Antikörper).

  9. DDR2 Missense mutation is associated with spondylo-meta-epiphyseal dysplasia, short limb-abnormal calcification type.

  10. Data suggest SCl2 (Streptococcus pyogenes) binds to DDR (DDR1, DDR2) ectodomain w/o stimulating receptor signaling; here, protein engineering was used to construct SCl (zeige KRT7 Antikörper)-like proteins that inhibit collagen-DDR (zeige DDR1 Antikörper) interactions and macrophage migration.

DDR2 Antigen-Profil

Beschreibung des Gens

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

Alternative names and synonyms associated with DDR2

  • discoidin domain receptor tyrosine kinase 2 (DDR2) Antikörper
  • discoidin domain receptor family, member 2b (ddr2b) Antikörper
  • discoidin domain receptor family, member 2 (LOC100356982) Antikörper
  • discoidin domain receptor family, member 2 (Ddr2) Antikörper
  • discoidin domain receptor tyrosine kinase 2 (Ddr2) Antikörper
  • AW495251 Antikörper
  • ddr2 Antikörper
  • MIG20a Antikörper
  • NTRKR3 Antikörper
  • si:ch211-193c2.1 Antikörper
  • TKT Antikörper
  • Tyro10 Antikörper

Bezeichner auf Proteinebene für DDR2

discoidin domain receptor tyrosine kinase 2 , discoidin domain receptor family, member 2 , CD167 antigen-like family member B , discoidin domain receptor 2 , discoidin domain-containing receptor 2 , neurotrophic tyrosine kinase, receptor-related 3 , receptor protein-tyrosine kinase TKT , tyrosine-protein kinase TYRO10 , cell migration-inducing protein 20 , discoidin domain-containing receptor tyrosine kinase 2 , hydroxyaryl-protein kinase , migration-inducing gene 16 protein , neurotrophic tyrosine kinase receptor related 3 , tyrosylprotein kinase , CD167b antigen , tyrosine-protein kinase TYRO 10

GENE ID SPEZIES
457467 Pan troglodytes
565333 Danio rerio
100356982 Oryctolagus cuniculus
18214 Mus musculus
4921 Homo sapiens
685781 Rattus norvegicus
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